Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1⁺/NKX6.1⁺ progenitors by Noura Aldous (15429873)

“…Upon differentiating iPSCs lacking RFX6 into pancreatic islets, a significant decrease in PDX1 expression at the PF stage was observed, although this did not affect PPs co-expressing PDX1 and NKX6.1. …”

Exendin-4 promotes GSIS without increasing β-cell number through upregulation of glucose-sensing apparatus and mitochondrial oxidative phosphorylation machinery genes in hPSC-deriv... by Abdoulaye Diane (14152749)

“…Interestingly, addition of Exendin-4 (50 nM) during the last 3 days of the differentiation significantly enhanced GSIS associated with increased expression of glucose-sensing apparatus genes (Glut2, G6P2C, GCK) and genes encoding mitochondrial oxidative phosphorylation machinery.…”

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss by Meritxell Espino Guarch (18810097)

Qatar’s immigrants at higher risk of diabetes by Nature Research (16552612)

“…The results, however, suggest that Qatar’s immigrant population has a significantly increased risk of having undiagnosed T2D, and that glycated haemoglobin levels could be a useful diagnostic tool for early detection of the disease. …”

Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model by Sahar Isa Da’as (18288880)

“…These knockout zebrafish displayed significant morphological heart alterations related to a significant decrease in ventricular and atrial diameters at systolic and diastolic states at the larval stages. …”

Arginine Deprivation in AML Cells Induces Ferroptosis, a Type of Autophagy-Mediated Cell Death by Tohme, Sara

“…Scavenging ROS using NAC significantly decreases cell death but has minimal effect on autophagy activation, suggesting that the accumulation of ROS is downstream of autophagy activation but upstream of cell death. …”
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Noninvasive assessment of coronary flow reserve in the left anterior descending artery by transthoracic echocardiography before and after stenting by Tarcha, Walid

“…However, after stenting the mean CFR was significantly higher: 2.18 ± 0.55 (1.3–3.8), with P <0.01. …”
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Noninvasive Assessment of Coronary Flow Reserve in the Left Anterior Descending Artery by Transthoracic Echocardiography before and after Stenting by Ghanem, Georges

“…However, after stenting the mean CFR was significantly higher: 2.18 ± 0.55 (1.3–3.8), with P <0.01. …”
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Dynamic Hybrid Cross-Docking Model with Multiple Truck Types by Holla, Sitara

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Growth hormone treatment modulates active ghrelin levels in rats by Haddad, Haytham

“…Genotropin treatment caused a dose dependent decrease in active ghrelin concentration in stomach, kidney and pancreas with a concomitant increase in plasma, and reaching significance at 20 and 100 µg/rat/day doses. …”
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Aorta deformation linked to heart disease by Nature Research (16552612)

“…They found that the mechanics of the aorta were altered, with the pulsatile change in aortic diameter, distention and elasticity of the aortic walls being significantly decreased, and aortic stiffness significantly increased, in HCM patients compared to the controls. …”

Longitudinal Study of Hypertensive Subjects With Type 2 Diabetes Mellitus by Bahous, Sola Aoun

“…Using cross-sectional regression models, a significant association was observed between higher education levels, lower levels of anxiety and depression, and reduced overall mortality in diabetic hypertensive subjects, while impaired renal function, a history of stroke and myocardial infarction, and increased alcohol and tobacco consumption were significantly associated with increased mortality. …”
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Protection of Banks Customers in the UAE by AlAwadhi, Ghaith Alhaj

“…On the other hand, the identified barriers include increased competition, cultural shift, and variations in business models.…”
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Voiding function improves under long-term testosterone treatment (TTh) in hypogonadal men, independent of prostate size by Aksam Yassin (14779204)

“…</p><h3>Results</h3><p dir="ltr">Prior to TTh interruption, it was observed that testosterone stimulation improved the men’s IPSS, AMS and post-voiding residual bladder volume, while their prostate volume significantly increased. During the TTh interruption, there was a significant worsening in these parameters, although the increase in prostate volume continued. …”

Assessment of Inventory and Transportation Collaboration in a Logistics Marketplace by Shahid, Saif Mohammad

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Effect of chronic and non-chronic moderate wine consumption upon rat lipoprotein profile in the blood. (c2002) by Slaiby, Rita

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Exploring Ultra-Processed Foods: Impact on Satiety, Eating Patterns, Blood Glucose Levels and Food Addiction by Mamo, Tracy G.

“…Characterized by hyper-palatable ingredients and extensive processing, UPFs contribute to increased caloric intake, impaired satiety signals, and a higher prevalence of addictive-like eating behaviors. …”
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The development of psychological and associated mental health disorders after road traffic crashes and other injuries by Anthony Joseph (3383735)

“…It appears that up to 33% of patients may develop a psychiatric illness after a traumatic injury and this may lead to significant functional impairment and social dysfunction. …”

Triple therapy with pravastatin, low molecular weight heparin and low dose aspirin improves placental haemodynamics and pregnancy outcomes in obstetric antiphospholipid syndrome in... by Eleftheria Lefkou (17052414)

“…</p><h3>Conclusion</h3><p dir="ltr">LMWH + LDA + PRAV increased serum NO levels and significantly improved placental haemodynamics and maternal and neonatal outcomes in women and mice with OAPS. …”

Hypoxic Stress Induces Complement-Mediated Lysis of Mesenchymal Stem Cells by Downregulating Factor H and CD59 by Ramada R. Khaswaneh (22224544)

“…</p><h3>Results</h3><p dir="ltr">Our results showed for the first time that severe hypoxia can significantly impair Factor H secretion and CD59 expression in MSCs. …”