Showing 41 - 60 results of 13,678 for search '(( significant decrease cgas ) OR ( significant cause decrease ))', query time: 1.08s Refine Results
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    Image_1_Extracellular vesicles from A23187-treated neutrophils cause cGAS-STING-dependent IL-6 production by macrophages.tif by Edwina R. Allen (13172643)

    Published 2022
    “…Given these unexpected results, we investigated whether macrophage mtDNA activated the cGAS-STING signaling axis. Consistent with mitochondrial outer membrane permeabilization (MOMP), a defined mechanism of mtDNA release, we observed macrophage mitochondrial membrane depolarization, a decrease in cytosolic Bax, and a decrease in mitochondrial cytochrome c, suggesting that macrophage mtDNA may initiate this EV-dependent signaling cascade. …”
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