Image 3_A nomogram model to predict the high risk of lower live birth probability in young women undergoing the first IVF-ET cycle: a retrospective study.tif by Chang Liu (35901)

“…</p>Methods<p>A prediction model was built including 9265 infertile women ≤ 35 years of age accepting their first ovum pick-up cycle from January 2018 to December 2022. …”

Data Sheet 1_Age-dependent effects of H2S on post-traumatic stress disorder in adolescent and adult mice.pdf by Bing Gu (276393)

“…In this study, we examined the influence of CBS/H₂S on anxiety and depression-like behavior following the inescapable foot shock (IFS) procedure during early adolescence (postnatal days 28-35) or adulthood (postnatal days 63-70).</p>Results<p>Our results showed that adult PTSD mice exhibited more pronounced decreases in H₂S content and CBS expression in the hippocampus, which were associated with anxiety and depression-like behavior compared with adolescent PTSD mice. …”

Supplementary file 2_Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression.docx by Jinghuai Ni (21023477)

“…In vitro experiments were conducted to evaluate the effects of SC on osteogenic and adipogenic differentiation in BMMSCs, MC3T3-E1, and 3T3-L1 cells.</p>Results<p>The results showed that SC treatment significantly improved bone mineral density (BMD), trabecular separation (Tb.Sp), trabecular thickness (Tb.Th), trabecular number (Tb.N), bone volume fraction (BV/TV), and trabecular pattern factor (Tb.Pf) in OVX mice. …”

Table 1_WTAP modulates macrophage polarization in rheumatoid arthritis by targeting exosomal circ-CBLB via m6A modification.docx by Dawei Yan (193244)

“…Protein-RNA interactions, macrophage polarization, and cytokine profiles were evaluated through RNA pull-down assays, RIP-qPCR, flow cytometry, and ELISA, respectively.</p>Results<p>In the enhanced inflammatory microenvironment of RA, circ-CBLB expression was observed to be significantly downregulated. …”

Table 1_ADAM8 in macrophages exacerbates sepsis-induced cardiomyopathy by impeding efferocytosis.docx by Zhenjun Ji (11050644)

“…RNA transcriptome sequencing was conducted on left ventricular tissues sourced from ADAM8 CKO mice, as well as on RAW264.7 cell lines that were treated with both ADAM8 knockdown (KD) lentivirus and LPS.</p>Results<p>Here, we demonstrate that ADAM8 expression is significantly upregulated in cardiac macrophages of SICM mice using single-cell transcriptomics and immunofluorescence. …”

Table 3_Age-Period-Cohort analysis and 2036 projections of the burden of ischemic stroke in Finland, Korea, Singapore and China, 1990–2021.xlsx by Jiayue Zhang (7832669)

“…Bayesian Age-Period-Cohort (BAPC) modeling was used to predict the incidence rates of different sex and age groups in 2036.</p>Results<p>The global all-age disability-adjusted life year (DALY) rate of ischemic stroke decreased by 34.90% between 1990 and 2021, with the highest disease burden in China, especially in males. …”

Image 4_Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study.... by Xuewen Rong (6242657)

“…The slope index of inequality for the mortality burden decreased from 1.97 to 1.62. After the policy shock, the age-standardized rate (ASR) of years lived with disability (YLD) in the Caribbean increased significantly to 4.59 (95% CI: 0.96 to 8.22), while the all-age YLD rate in the U.S. increased (5.18, 95% CI: 0.66 to 9.70) for both sexes.…”

DataSheet1_Association between amoxicillin administration and outcomes in critically ill patients with acute kidney injury.PDF by Xinyao Luo (12084194)

“…</p>Materials and Methods<p>We conducted a retrospective cohort analysis utilizing data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. …”

Supplementary file 1_Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression.docx by Jinghuai Ni (21023477)

“…In vitro experiments were conducted to evaluate the effects of SC on osteogenic and adipogenic differentiation in BMMSCs, MC3T3-E1, and 3T3-L1 cells.</p>Results<p>The results showed that SC treatment significantly improved bone mineral density (BMD), trabecular separation (Tb.Sp), trabecular thickness (Tb.Th), trabecular number (Tb.N), bone volume fraction (BV/TV), and trabecular pattern factor (Tb.Pf) in OVX mice. …”

Image 3_Unraveling impact and potential mechanisms of baseline pain on efficacy of immunotherapy in lung cancer patients: a retrospective and bioinformatic analysis.jpg by Zexin Zhang (7507979)

“…ELISA assay results indicated that the level of CXCL12 significantly decreased compared to baseline after pain was relieved.…”

DataSheet1_Lipocalin-2 drives neuropsychiatric and cutaneous disease in MRL/lpr mice.docx by Sayra J. Garcia (19748644)

“…Systemic disease was evaluated through measuring anti-nuclear antibodies by ELISA.</p>Results<p>In this study, we found that LCN2 deficiency significantly attenuates neuropsychiatric and cutaneous disease in MRL/lpr lupus prone mice, likely by decreasing local infiltration of immune cells into the brain and skin and reducing astrocyte activation in the hippocampus. …”

Table 6_Age-Period-Cohort analysis and 2036 projections of the burden of ischemic stroke in Finland, Korea, Singapore and China, 1990–2021.xlsx by Jiayue Zhang (7832669)

“…Bayesian Age-Period-Cohort (BAPC) modeling was used to predict the incidence rates of different sex and age groups in 2036.</p>Results<p>The global all-age disability-adjusted life year (DALY) rate of ischemic stroke decreased by 34.90% between 1990 and 2021, with the highest disease burden in China, especially in males. …”

Data Sheet 1_Pan-cancer analysis reveals TRA16 as a master regulator of human carcinogenesis.pdf by Yanyan Zhu (32035)

“…Importantly, patients with high TRA16 expression demonstrated elevated TMB and decreased stromal and immune features.</p>Discussion<p>These findings highlight TRA16 as a potential master regulator of oncogenic processes, contributing to tumor progression through coordinated regulation of cell cycle genes, intercellular signaling, and genomic instability. …”

Point Application Therapy Targeting Feishu, Pishu and Shenshu Attenuates Asthma by Suppressing Autophagy and the AMPK-mTOR Signalling Pathway by Yutong Jin (2873837)

“…We subsequently measured inflammatory factor levels in rat serum and bronchoalveolar lavage fluid, quantified AMPK/mTOR pathway-related protein expression, and assessed pulmonary inflammation alongside collagen deposition in airway mucosa.</p> <p>The point application therapy significantly ameliorated asthma symptoms and reduced levels of inflammatory factors, including interleukin (IL)-6 and IL-1β, in both serum and bronchoalveolar lavage fluid. …”

Image 3_Age-dependent effects of H2S on post-traumatic stress disorder in adolescent and adult mice.jpeg by Bing Gu (276393)

“…In this study, we examined the influence of CBS/H₂S on anxiety and depression-like behavior following the inescapable foot shock (IFS) procedure during early adolescence (postnatal days 28-35) or adulthood (postnatal days 63-70).</p>Results<p>Our results showed that adult PTSD mice exhibited more pronounced decreases in H₂S content and CBS expression in the hippocampus, which were associated with anxiety and depression-like behavior compared with adolescent PTSD mice. …”

Data Sheet 1_Early coronary angiography in patients with myocardial infarction without ST elevation after out-of-hospital cardiac arrest: a systematic review and meta-analysis.pdf by Warda Ahmed (5593586)

“…Background<p>Early coronary angiography (CAG) in post-cardiac arrest patients without ST-segment elevation is a topic of debate. …”

Data Sheet 1_Effect of cultivation feed diet using local food processing by-products on the growth and flavor factor in the Malabar grouper Epinephelus malabaricus.docx by Makoto Takahashi (386772)

“…Growth performance, liver somatic index, insulin-like growth factor 1 (IGF-1) gene expression, and muscle taste-related components were analyzed.</p>Results<p>FW-D-fed fish showed slightly lower growth performance, possibly due to decreased protein content. …”

Image 1_MFN2-a multifaceted guardian against Parkinson’s pathophysiology: mitochondria, ferroptosis, inflammation and oxidative stress.tif by Yan Cheng (149222)

“…Subsequently, a series of experiments such as qRT-PCR, Western blot, CCK-8, flow cytometry and ELISA were used to verify the potential mechanism of MFN2.</p>Results<p>In PD models, the expressions of DHODH, MFN1, MFN2, GPX4, and FSP1 were significantly down-regulated, and their motor coordination, self-cognitive behavior, and exploration ability were decreased. …”

Table 1_LncRNA OIP5-AS1 suppresses lung adenocarcinoma progression and modulates macrophage polarization through the miR-429/DOCK4 regulatory axis.docx by Yihan Liu (2258221)

“…Macrophage polarization and migratory capacity were assessed following manipulation of OIP5-AS1, miR-429, and DOCK4 expression.</p>Results<p>OIP5-AS1 expression was significantly decreased in LUAD tissues and associated with poor survival. …”

Image 1_Age-dependent effects of H2S on post-traumatic stress disorder in adolescent and adult mice.jpeg by Bing Gu (276393)

“…In this study, we examined the influence of CBS/H₂S on anxiety and depression-like behavior following the inescapable foot shock (IFS) procedure during early adolescence (postnatal days 28-35) or adulthood (postnatal days 63-70).</p>Results<p>Our results showed that adult PTSD mice exhibited more pronounced decreases in H₂S content and CBS expression in the hippocampus, which were associated with anxiety and depression-like behavior compared with adolescent PTSD mice. …”