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significant 17 » significant _ (Expand Search), significant co (Expand Search), significant anti (Expand Search)
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21061
Table 5_Identification of potential miRNA biomarkers for neurobrucellosis diagnosis.xlsx
Published 2025“…Among these, four common miRNAs (miR-342-3p, miR-576-5p, miR-15b-5p and miR-499a-5p) were significantly elevated in the infection group compared to controls in both the in-house and validation cohorts. …”
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21062
Data Sheet 2_The effects of acute and chronic exercise on immune markers of TH1/TH2 cells in older adults: a systematic review.pdf
Published 2025“…</p>Conclusion<p>Chronic exercise decreases serum TNF-α and IL-6 levels, lowers the CD4/CD8 ratio, and increases IL-10 after 24 weeks, aiding Th1 and Th2 balance. …”
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21063
Image 3_A metagenome-wide association study of gut microbiota in hepatitis B virus-related cirrhosis in northwest China.tif
Published 2025“…</p>Conclusion<p>HBV-LC patients in Northwest China exhibit altered clinical indicators, gut microbial composition (reduced diversity, increased opportunistic pathogens, decreased beneficial species), and metabolic function. …”
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21064
Data Sheet 1_Salvia deserti Decne., an endemic and rare subshrub from Arabian desert: antidiabetic and antihyperlipidemic effects of leaf hydroethanolic extracts.doc
Published 2025“…</p>Results<p>Oral administration of hydroethanolic extract of S. deserti at 200 and 400 mg/kg for 14 days significantly decreased blood glucose and restored the hepatic and renal function by reducing the levels of ALT, AST, ALP, GGT, LDH, urea and creatinine. …”
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21065
DNA damage protecting effects of MEExCC.
Published 2025“…The results demonstrated that higher doses (200 mg) of <i>C. chinense</i> methanol extract inhibited immune responses, whereas lower doses helped restore them. The extracts significantly decreased pro-inflammatory mediators and cytokines in LPS-activated macrophages. …”
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21066
Image 1_Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma.tif
Published 2025“…In vitro, the overexpression of miR-4739 in Huh-7 cells significantly induced SPP1<sup>+</sup> macrophages, and the culture medium derived from SPP1<sup>+</sup> macrophages further promoted the proliferation and migration of Huh-7 cells. …”
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21067
Image 3_The immunomodulatory and antitumor properties of the bacterial metalloprotease Oligopeptidase A are mediated by TLR4/MyD88/TRIF and MAPK signaling pathways.tiff
Published 2025“…</p>Results<p>Heat-inactivated OpdA significantly reduced metastasis, dependent on tumor-specific CD4+ and CD8+ T cells and IFN-γ, both locally and systemically, with decreased IL-10 levels suggesting a proinflammatory environment. …”
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21068
Table 4_Integrated analysis of miRNAs-mRNAs in skeletal muscle development revealed that novel-miR-766 affects myoblast differentiation and myofiber-type formation in sheep.xlsx
Published 2025“…In vitro assays revealed that myoblast differentiation and myotube formation were significantly inhibited by MYH3 knockdown via siMYH3 and that novel-miR-766 targets and decreases the expression of MYH3. …”
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21069
Data Sheet 2_Global burden of nasopharyngeal carcinoma attributable to alcohol use: a 1990–2021 analysis with projections to 2040.zip
Published 2025“…</p>Results<p>From 1990 to 2021, global ASMR declined from 0.31 to 0.19 per 100,000 population (AAPC −1.66; 95% CI −1.79 to −1.52) and ASDR fell with an AAPC of −1.72 (95% CI −1.87 to −1.57). Male ASMR decreased from 0.42 to 0.27 per 100,000 (AAPC −1.60), and female ASMR from 0.21 to 0.12 per 100,000 (AAPC −2.25). …”
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21070
Hypoxia response and tracheogenesis in <i>PGR</i> mutants.
Published 2025“…Homozygous mutant pupae did not show significantly higher expression of <i>bnl</i> until 96 hours APF. …”
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21071
Table1_Causal association between inflammatory bowel disease and acute pancreatitis: a two-sample bidirectional mendelian randomization study.XLSX
Published 2024“…Interestingly, AP was suggestively associated with a decreased risk of CD (OR = 0.797, 95% CI = 0.637-0.997, p = 0.047). …”
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21072
Flexible Microfluidic Devices for Tunable Formation of Double Emulsion
Published 2025“…This innovative approach significantly advances the field of droplet-based microfluidics, providing on-site, real-time tunability for the generation of double-emulsion droplets with high precision and reproducibility.…”
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21073
Table3_The long-term prognostic implications of free triiodothyronine to free thyroxine ratio in patients with obstructive sleep apnea and acute coronary syndrome.jpg
Published 2024“…The FT3/FT4 ratio between OSA and non-OSA patients was not significantly different. During 2.8 (1.4, 3.5) years follow up, the risk of MACCE increased with the decreasing FT3/FT4 tertiles in patients with OSA (tertile3 as reference, tertile2: hazard ratio (HR) 1.26, 95% CI: 0.85-1.86, P = 0.255; tertile1: 1.60, 95% CI 1.11-2.32; P = 0.013). …”
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21074
Table 2_Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma.xlsx
Published 2025“…In vitro, the overexpression of miR-4739 in Huh-7 cells significantly induced SPP1<sup>+</sup> macrophages, and the culture medium derived from SPP1<sup>+</sup> macrophages further promoted the proliferation and migration of Huh-7 cells. …”
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21075
Data Sheet 1_The effects of acute and chronic exercise on immune markers of TH1/TH2 cells in older adults: a systematic review.pdf
Published 2025“…</p>Conclusion<p>Chronic exercise decreases serum TNF-α and IL-6 levels, lowers the CD4/CD8 ratio, and increases IL-10 after 24 weeks, aiding Th1 and Th2 balance. …”
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21076
Supplementary file 1_Comparative analysis of accuracy and completeness in standardized database generation for complex multilingual lung cancer pathological reports: large language...
Published 2025“…In English reports, it matched mainstream AI in lesion analysis (p > 0.05) but excelled in lymph node/pathology metrics (p < 0.05). Task load scores decreased by 38.3% post-implementation (413.90 ± 78.09 vs. 255.30 ± 65.50, t = 26.481, p < 0.001).…”
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21077
Data Sheet 1_Influence of age-adjusted shock index trajectories on 30-day mortality for critical patients with septic shock.zip
Published 2025“…KM curve revealed significantly higher 30-day mortality in Class 2 (32.1%) and Class 3 (38.7%) than Class 1 (12.3%) (P < 0.001). …”
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21078
Data Sheet 1_Soy-based purified ingredient diet affects mouse gut permeability and the microbiome in fragile X mice.pdf
Published 2025“…Beta-diversity of the cecal microbiome was significantly altered as a function of the four test diets. …”
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21079
<b>Combination of isobavachalcone and amphotericin B has antifungal effect against </b><b>Cryptococcus neoformans</b><b>and protects host tissue damage by inhibiting ferroptosis</b...
Published 2025“…The results demonstrated that IBC (4 μg/mL) significantly reduced the minimum inhibitory concentration (MIC) of AmB from 1 μg/mL to 0.25 μg/mL, indicating a fourfold increase in potency. …”
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21080
Table 1_LncRNA NEAT1 promotes epithelial–mesenchymal transition in nasal polyp cells via the miR-199-3p/PAK4 axis.docx
Published 2025“…</p>Results<p>In comparison to controls, NEAT1 expression was significantly elevated in the epithelial tissues of CRSwNP. …”