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significant i » significant _ (Expand Search), significant co (Expand Search), significant 17 (Expand Search)
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6301
Image 1_MFN2-a multifaceted guardian against Parkinson’s pathophysiology: mitochondria, ferroptosis, inflammation and oxidative stress.tif
Published 2025“…</p>Results<p>In PD models, the expressions of DHODH, MFN1, MFN2, GPX4, and FSP1 were significantly down-regulated, and their motor coordination, self-cognitive behavior, and exploration ability were decreased. …”
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6302
Supplementary file 1_Efficacy of Xiaoyao-san preparations in treating Hashimoto’s thyroiditis: a meta-analysis and systematic review.zip
Published 2025“…Meta-analysis demonstrated that XYS preparations significantly reduced TPOAb levels [SMD = −0.74, 95% CI (−1.02, −0.46), p < 0.00001]. …”
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6303
DataSheet1_Treatment and molecular analysis of bullous pemphigoid with tofacitinib: a case report and review of current literature.docx
Published 2024“…Glucocorticosteroids are the main therapeutic agents for it, but their efficacy is poor in some patients. Tofacitinib, a small molecule agent that inhibits JAK1/3, has shown incredible efficacy in a wide range of autoimmune diseases and maybe a new valuable treatment option for refractory BP.…”
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6305
Table 1_Unsupervised machine learning revealed a correlation between low-dose statins and favorable outcomes in ICH patients.docx
Published 2025“…The low-dose statin group exhibited reduced mortality (p = 0.001), a decreased rate of unfavorable functional outcomes (p < 0.001), and fewer cerebrovascular events (p < 0.001). …”
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6306
Table 1_Therapeutic potential of luteolin in central precocious puberty: insights from a danazol-induced rat model.xlsx
Published 2025“…</p>Results<p>In the danazol-induced CPP model, luteolin treatment significantly decreased the abundances of Estradiol (E2), luteinizing hormone serum, and follicle-stimulating hormone in sera; reduced organ coefficients and ovarian and uterine wet weights; and delayed vaginal opening. …”
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6307
Table 1_Moderating effects of a healthy lifestyle on the association of pre-metabolic syndrome with multiple chronic disease comorbidities.docx
Published 2025“…Integrate healthy lifestyles and explore their association with multiple comorbidities using normal metabolism and healthy lifestyles as reference groups. PreMetS [OR = 1.38, 95%CI: 1.16–1.64] and MetS [OR = 1.61, 95%CI: 1.32–1.97] were associated with a significantly higher risk of multiple comorbidities compared with the normal population, and the risk of multiple comorbidities tended to increase as the number of metabolic disorder components increased (p < 0.001). …”
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6308
Table1_Causal relationship between plasma lipidome and four types of pancreatitis: a bidirectional Mendelian randomization study.xlsx
Published 2024“…</p>Results<p>After FDR correction, SE (27:1/20:4) (OR = 0.938, 95%CI = 0.906-0.972, P = 4.38 × 10<sup>-4</sup>, PFDR = 0.039) was identified to be significantly associated with AP risk. …”
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6309
Table 1_Temporal trends and geographic disparities in thyroid cancer burden: a global analysis from 1990 to 2021.doc
Published 2025“…</p>Results<p>In 2021, the global thyroid cancer burden was substantial, with 1,987,148.5 cases. From 1990 to 2021, the ASPR increased from 14.9 (95% Uncertainty Interval [UI]: 14.1–16.0) to 23.1 (95% UI: 20.7–25.6) per 100,000 population, with an EAPC of 1.58 (95% UI: 1.44–1.73); the ASIR increased from 2.1 (95% UI: 2–2.2) to 2.9 (95% UI: 2.6–3.2) per 100,000 population, with an EAPC of 1.25 (95% UI: 1.14–1.37); the ASDR declined from 0.6 (95% UI: 0.5–0.6) to 0.5 (95% UI: 0.5–0.6) per 100,000 population, with an EAPC of −0.24 (95% UI: −0.24 – −0.21); the age - standardized DALY rate decreased from 15.2 (95% UI: 14.2–16.8) to 14.6 (95% UI: 12.8–16.1) per 100,000 population, with an EAPC of −0.14 (95% UI: −0.17 – –0.11). …”
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6313
Table1_Cuproptosis-related lncRNAs emerge as a novel signature for predicting prognosis in prostate carcinoma and functional experimental validation.docx
Published 2024“…SNHG9 knockdown resulted in a significant increase in G1 phase cells and a decrease in S and G2 phases, indicating inhibition of DNA synthesis and cell cycle progression. …”
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6314
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6315
Data for 'Elevated developmental temperatures below the lethal limit reduce <i>Aedes aegypti </i>fertility'
Published 2024“…<p dir="ltr"><i>Aedes aegypti</i> mosquitoes are the principal vectors of dengue and continue to pose a threat to human health, with ongoing urbanization, climate change, and trade all impacting the distribution and abundance of this species. …”
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6316
Data Sheet 1_Understanding mechanistic relationships between IgG titers and Fc effector functions: a computational framework to assess polyfunctionality.docx
Published 2025“…Surprisingly, simulated boosting of IgG3 alone had the potential to significantly decrease ADCP (p<0.00001), though it would increase ADCC responses. …”
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6317
Biotransformation Dynamics and Products of Cyanobacterial Secondary Metabolites in Surface Waters
Published 2025“…We assessed biotransformation for 40 cyanopeptides including microcystins, anabaenopeptins and cyanopeptolins in surface waters and <i>in situ</i> enriched biofilm suspensions. In surface waters, most cyanopeptides did not degrade significantly over the course of 7 days. …”
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6318
Data Sheet 1_Yerba Maté and its impact on glycemic control and metabolic health: a systematic review and meta-analysis.docx
Published 2025“…The results with pre-diabetes patients suggest significant decreases in postprandial glucose (MD -12.76, 95% CI -16.78, -8.74; N = 2), HbA1c (MD -0.37, 95% CI -0.56, -0.18; N = 2), and the homeostatic model assessment index (HOMA index) (MD -0.24, 95% CI -0.37, -0.11; N = 2), though further research is needed to confirm these findings. …”
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6320