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significant changes » significant challenge (Expand Search)
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19761
Participants baseline characteristics.
Published 2025“…The clinical trial’s results showed that MMF treatment had a positive effect on the improvement of BMD in the lumbar spine and increased serum P1NP levels while decreased β-CTX levels. In addition, MMF treatment decreased participants’ VAS scores for low back pain.…”
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19762
Table 2_Multi-omics reveals total flavones from Abelmoschus manihot (L.) Medik. [Malvaceae] ameliorate MAFLD via PI3K/AKT/mTOR-mediated autophagy.docx
Published 2025“…In MAFLD mice, TFA treatment significantly decreased body weight gain, hepatic lipid accumulation, and the serum levels of ALT, AST, TC, and TG. …”
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19763
Flowchart of the clinical trial.
Published 2025“…The clinical trial’s results showed that MMF treatment had a positive effect on the improvement of BMD in the lumbar spine and increased serum P1NP levels while decreased β-CTX levels. In addition, MMF treatment decreased participants’ VAS scores for low back pain.…”
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19764
Reduced expression of MYBPC3 mRNA and cMyBP-C protein in the proband.
Published 2025“…<p>(A) RT-qPCR analysis showing significantly decreased MYBPC3 mRNA levels in cardiac sample from the proband compared to control subjects. …”
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19765
<b>Effects of resveratrol supplementation on performance and metabolic adaptations in heat-stressed Holstein cows during early lactation–A preliminary study</b>
Published 2025“…Serum non-esterified fatty acids and insulin levels, and aspartate aminotransferase activity decreased significantly, while glucose level and alanine aminotransferase activity showed a downward trend. …”
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19766
Protective role of <i>N</i>-acetyl-l-tryptophan against hepatic ischemia-reperfusion injury via the RIP2/caspase-1/IL-1β signaling pathway
Published 2024“…Similarly, IL-1β activity and caspase-1 activity were significantly decreased in the H<sub>2</sub>O<sub>2</sub> group when compared with the controls, after l-NAT intervention.…”
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19767
The Gigante Litter Manipulation Experiment
Published 2024“…Soil nitrate and nitrogen (N) concentrations in roots and leaves decreased quickly and significantly with litter removal (LR) and increased quickly and significantly with litter addition (LA). …”
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19768
Cows' BHB impacts on calf BAT growth and metabolic health
Published 2025“…The results showed that although high BHB levels had no effect on calf birth weight or growth, they significantly impaired glucose sensitivity, increased stress genes and decreased brown adipose tissue mass, thermogenic proteins and mitochondrial density. …”
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19769
The effects of CHRM2 knockdown on osteogenic differentiation and cell proliferation.
Published 2025“…(B) The RT-qPCR results showed that the expression of CHRM2 in cells with Si-CHRM2 knockdown decreased significantly. (C) The cell proliferation were measured by OD value at 450 nm, and the observation time points were at 0, 24, 48, 72 and 96 hours. …”
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19770
Table 1_Influence of age and sex on the diagnostic accuracy of pleural fluid carcinoembryonic antigen for malignant pleural effusion: a post hoc analysis.docx
Published 2025“…Subgroup analyses with both cohorts revealed the decreased AUC in older patients. The resampling method revealed decreased AUC with the advancement of age.…”
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19771
Data Sheet 2_Menthone lowers H3K27ac levels to inhibit Fusarium proliferatum growth.xlsx
Published 2025“…</p>Results<p>This study demonstrated that menthone, the primary component of Mentha haplocalyx EO, exhibited notable antifungal activity against Fusarium proliferatum (EC50 = 6.099 mmol/L). The treatment significantly inhibited hyphal growth, reduced spore germination rates from 31.49 to 4.95%, decreased spore viability from 46.88 to 20.91%, and reduced spore production by a factor of 17.92 compared with the control group while simultaneously enhancing cell membrane permeability. …”
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19772
<b>Litter decomposition regulated by stand ECM dominance but not litter mycorrhizal type in a subtropical mountainous forest</b>
Published 2025“…</a> AM and ECM litter decomposition in plots with a natural gradient of ECM tree dominance showed that the decomposition rates of both AM litter and ECM litter decreased significantly in plots with increasing ECM dominance. …”
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19773
Table1_Maslinic acid induces autophagy and ferroptosis via transcriptomic and metabolomic reprogramming in prostate cancer cells.xlsx
Published 2024“…Herein we found that MA inhibits prostate cancer cell proliferation by decreasing CDK2, CDK4, and CDK6 expression and concurrently increasing p27, Rb, p-Rb expression. …”
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19774
Table3_Maslinic acid induces autophagy and ferroptosis via transcriptomic and metabolomic reprogramming in prostate cancer cells.xlsx
Published 2024“…Herein we found that MA inhibits prostate cancer cell proliferation by decreasing CDK2, CDK4, and CDK6 expression and concurrently increasing p27, Rb, p-Rb expression. …”
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19775
Data Sheet 1_Shengxian decoction alleviates cyclophosphamide-induced immunosuppression via improving B cell-mediated immune responses.docx
Published 2025“…</p>Results<p>SXD treatment ameliorates decreased splenic and thymic organ indexes, as well as decreased lymphocyte number in the spleen in immunosuppressed mice. …”
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19776
Image 1_Vitamin K protects against lipopolysaccharide-induced intestinal inflammation in piglets by inhibiting the MAPK and PI3K-AKT pathways.pdf
Published 2025“…</p>Results<p>Morphological analysis revealed that VK significantly restored the decreased villus height and ratio of villus height to crypt depth induced by LPS. …”
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19777
Effect of soil salinity on cotton cultivation and the potential for introducing <i>Amaranthaceae</i> halophytes in the Yellow River Delta, China
Published 2025“…Levels of major (K<sup>+</sup>, Ca<sup>2+</sup> and Mg<sup>2+</sup>) or minor (Fe<sup>2+</sup>, Mn<sup>2+</sup>, Zn<sup>2+</sup> and Cu<sup>2+</sup>) essential elements were not significantly decreased by the increase of field EC in any plant species, except for K<sup>+</sup> in <i>S</i>. …”
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19778
Data Sheet 1_Growth regulation mechanism of Rhododendron moulmainense to high-temperature stress: integrated physiological, transcriptomic, and metabolomic insights.docx
Published 2025“…The findings demonstrated that high-temperature stress decreased chlorophyll fluorescence and contents, which was validated by the damaged chloroplast structure in transmission electron microscopy. …”
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19779
Image 1_Growth regulation mechanism of Rhododendron moulmainense to high-temperature stress: integrated physiological, transcriptomic, and metabolomic insights.jpg
Published 2025“…The findings demonstrated that high-temperature stress decreased chlorophyll fluorescence and contents, which was validated by the damaged chloroplast structure in transmission electron microscopy. …”
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19780
Image 2_Growth regulation mechanism of Rhododendron moulmainense to high-temperature stress: integrated physiological, transcriptomic, and metabolomic insights.jpg
Published 2025“…The findings demonstrated that high-temperature stress decreased chlorophyll fluorescence and contents, which was validated by the damaged chloroplast structure in transmission electron microscopy. …”