Search alternatives:
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
significant causal » significant cause (Expand Search), significant clinical (Expand Search), significant clusters (Expand Search)
significant i » significant _ (Expand Search), significant co (Expand Search), significant 17 (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
significant causal » significant cause (Expand Search), significant clinical (Expand Search), significant clusters (Expand Search)
significant i » significant _ (Expand Search), significant co (Expand Search), significant 17 (Expand Search)
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Causal relationships between allergic diseases and significant declines in lung function: a multivariable Mendelian randomization study
Published 2025“…However, in multivariable MR analysis, the independent effects of atopic dermatitis and allergic conjunctivitis on lung function were no longer significant. Only allergic asthma continued to show a significant causal relationship with decreased lung function (OR [95%CI]: 1.019 [1.008–1.030], <i>p</i> < .001).…”
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Heterogeneity analysis.
Published 2025“…Instrumental variables (IVs) were identified as genome-wide significant single-nucleotide polymorphisms (SNPs) with a significance threshold of <i>P </i>< 1 × 10<sup>−8</sup> and an independence criterion of <i>r</i><sup>2</sup> < 0.001. …”
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Reverse MR analysis data.
Published 2025“…Instrumental variables (IVs) were identified as genome-wide significant single-nucleotide polymorphisms (SNPs) with a significance threshold of <i>P </i>< 1 × 10<sup>−8</sup> and an independence criterion of <i>r</i><sup>2</sup> < 0.001. …”
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SNP dressing by screening.
Published 2025“…Instrumental variables (IVs) were identified as genome-wide significant single-nucleotide polymorphisms (SNPs) with a significance threshold of <i>P </i>< 1 × 10<sup>−8</sup> and an independence criterion of <i>r</i><sup>2</sup> < 0.001. …”
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Flowchart of literature screening process.
Published 2025“…Interestingly, a potential causal relationship between hydroxychloroquine use and lower infection risk was observed in the cohort studies subgroup (OR = 0.66, 95%CI 0.44-0.99, p = 0.04), but not in the case-control studies subgroup (OR = 1.06, 95%CI 0.63-1.79, p = 0.83). …”
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Basic characteristics of included literature.
Published 2025“…Interestingly, a potential causal relationship between hydroxychloroquine use and lower infection risk was observed in the cohort studies subgroup (OR = 0.66, 95%CI 0.44-0.99, p = 0.04), but not in the case-control studies subgroup (OR = 1.06, 95%CI 0.63-1.79, p = 0.83). …”
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Raw data.
Published 2025“…Interestingly, a potential causal relationship between hydroxychloroquine use and lower infection risk was observed in the cohort studies subgroup (OR = 0.66, 95%CI 0.44-0.99, p = 0.04), but not in the case-control studies subgroup (OR = 1.06, 95%CI 0.63-1.79, p = 0.83). …”
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Forest plot of overall analysis results.
Published 2025“…Interestingly, a potential causal relationship between hydroxychloroquine use and lower infection risk was observed in the cohort studies subgroup (OR = 0.66, 95%CI 0.44-0.99, p = 0.04), but not in the case-control studies subgroup (OR = 1.06, 95%CI 0.63-1.79, p = 0.83). …”
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Forest plot for subgroups of infection types.
Published 2025“…Interestingly, a potential causal relationship between hydroxychloroquine use and lower infection risk was observed in the cohort studies subgroup (OR = 0.66, 95%CI 0.44-0.99, p = 0.04), but not in the case-control studies subgroup (OR = 1.06, 95%CI 0.63-1.79, p = 0.83). …”
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Details of the GWAS data in this study.
Published 2025“…</p><p>Results</p><p>This study shows that increases of anti-H. pylori IgG seropositivity was significantly associated with an increased risk of CHD (OR=1.003, 95% CI:1.0001.006, P = 0.048) and increases in peak insulin response (β = 0.214, 95% CI: 0.025–0.403, P = 0.026), decrease in total free cholesterol levels (β = ‒0.031, 95% CI: ‒0.061 to ‒0.000, P = 0.045), decreased waist circumference (β = ‒0.073, 95% CI: ‒0.138 to ‒0.008, P = 0.027) and waist-to-hip ratio (β = ‒0.069, 95% CI: ‒0.136 to ‒0.002, P = 0.044). …”
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