DataSheet1_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer... by Huijing Ren (19986303)

“…The results demonstrated that the combined administration of these 4 components (CPGB) had superior mitigating effects on AD cell model, as evidenced by the reduced pro-inflammatory cytokine production and decreased deposition of Aβ protein. Further in vivo and in vitro experiments confirmed that varying doses of CPGB formula effectively ameliorated STZ-induced cognitive deficits, as shown by NOR, MWM, and EMP tests, as well as pathological changes in hippocampal tissues and a 3-dimensional brain neurovascular unit (3D-NVU) model, including decreased deposition of Aβ protein and formation of plaques. …”

Image1_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d... by Huijing Ren (19986303)

“…The results demonstrated that the combined administration of these 4 components (CPGB) had superior mitigating effects on AD cell model, as evidenced by the reduced pro-inflammatory cytokine production and decreased deposition of Aβ protein. Further in vivo and in vitro experiments confirmed that varying doses of CPGB formula effectively ameliorated STZ-induced cognitive deficits, as shown by NOR, MWM, and EMP tests, as well as pathological changes in hippocampal tissues and a 3-dimensional brain neurovascular unit (3D-NVU) model, including decreased deposition of Aβ protein and formation of plaques. …”

Image 8_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Table 5_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Table 10_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Image 3_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Image 5_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Image 4_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Image 12_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Table 1_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Table 3_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Image 10_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Table 2_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Image 11_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Image 1_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Table 8_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Table 6_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Image 13_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Image 7_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Image 9_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”