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significant changes » significant challenge (Expand Search)
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19261
Image 5_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.png
Published 2025“…Moreover, depletion of LAMs attenuated iron overload caused acceleration of AML progression.</p>Conclusions<p>Collectively, this study reveals the significance of iron overload in remodeling hematopoietic ecosystem and affecting HSC and LAM function in AML, providing new insights into the multifaceted role of iron overload in leukemia.…”
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19262
Supplementary Material for: Hemispherotomy for Drug-Resistant Epilepsy in a Low-resource Setting: Surgical Outcomes and Quality of Life in 23 Children Treated in a Hybrid Program i...
Published 2025“…Patients with seizure freedom had significantly fewer preoperative seizures per day than patients with seizure recurrence. …”
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19263
Data Sheet 1_Soy-based purified ingredient diet affects mouse gut permeability and the microbiome in fragile X mice.pdf
Published 2025“…Beta-diversity of the cecal microbiome was significantly altered as a function of the four test diets. …”
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19264
<i>Salmonella </i>Typhimurium <i>StiP</i>-mediated upregulation of membrane protein Alx drives complement evasion via CFI-dependent C3b degradation
Published 2025“…<p dir="ltr">Invasive Salmonella Typhimurium (<i>S</i>. Typhimurium) causes lethal bloodstream infections (BSI), yet its molecular mechanisms remain unclear. …”
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19265
Table S13 from Functional Mapping of Epigenomic Regulators Uncovers Coordinated Tumor Suppression by the HBO1 and MLL1 Complexes
Published 2025“…<p>Categories and percent frequency of significantly decreased chromatin accessibility regions</p>…”
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19266
Image 6_Protective effects of soybean peptides on H2O2-induced oxidative injury in IPEC-J2 cells.jpeg
Published 2024“…However, pretreatment with SBP followed by H<sub>2</sub>O<sub>2</sub> inducement significantly increased cell viability to 72.99%, decreased cell apoptosis, increased SOD, CAT and GSH-Px activity (p < 0.05), down-regulated Bax and Caspase-3 gene expressions (p < 0.05), and up-regulated the gene expressions of ZO-1, Claudin-1, Occludin, catalase, glutathione GPX1, SOD1, HO-1, NQO1 and Nrf2, compared with the single H<sub>2</sub>O<sub>2</sub>–induced cells. …”
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19267
Table 1_The health burden of disease attributable to low calcium intake: a comprehensive analysis of trends and socioeconomic impacts from 1990 to 2021.docx
Published 2025“…</p>Conclusion<p>DLC significantly increases the incidence of CRC, while its impact on prostate cancer incidence is relatively minor and shows a negative correlation. …”
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19268
Image 4_Protective effects of soybean peptides on H2O2-induced oxidative injury in IPEC-J2 cells.jpeg
Published 2024“…However, pretreatment with SBP followed by H<sub>2</sub>O<sub>2</sub> inducement significantly increased cell viability to 72.99%, decreased cell apoptosis, increased SOD, CAT and GSH-Px activity (p < 0.05), down-regulated Bax and Caspase-3 gene expressions (p < 0.05), and up-regulated the gene expressions of ZO-1, Claudin-1, Occludin, catalase, glutathione GPX1, SOD1, HO-1, NQO1 and Nrf2, compared with the single H<sub>2</sub>O<sub>2</sub>–induced cells. …”
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19269
Image 3_Protective effects of soybean peptides on H2O2-induced oxidative injury in IPEC-J2 cells.jpeg
Published 2024“…However, pretreatment with SBP followed by H<sub>2</sub>O<sub>2</sub> inducement significantly increased cell viability to 72.99%, decreased cell apoptosis, increased SOD, CAT and GSH-Px activity (p < 0.05), down-regulated Bax and Caspase-3 gene expressions (p < 0.05), and up-regulated the gene expressions of ZO-1, Claudin-1, Occludin, catalase, glutathione GPX1, SOD1, HO-1, NQO1 and Nrf2, compared with the single H<sub>2</sub>O<sub>2</sub>–induced cells. …”
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19270
Image 5_Protective effects of soybean peptides on H2O2-induced oxidative injury in IPEC-J2 cells.jpeg
Published 2024“…However, pretreatment with SBP followed by H<sub>2</sub>O<sub>2</sub> inducement significantly increased cell viability to 72.99%, decreased cell apoptosis, increased SOD, CAT and GSH-Px activity (p < 0.05), down-regulated Bax and Caspase-3 gene expressions (p < 0.05), and up-regulated the gene expressions of ZO-1, Claudin-1, Occludin, catalase, glutathione GPX1, SOD1, HO-1, NQO1 and Nrf2, compared with the single H<sub>2</sub>O<sub>2</sub>–induced cells. …”
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19271
Image 2_Protective effects of soybean peptides on H2O2-induced oxidative injury in IPEC-J2 cells.jpeg
Published 2024“…However, pretreatment with SBP followed by H<sub>2</sub>O<sub>2</sub> inducement significantly increased cell viability to 72.99%, decreased cell apoptosis, increased SOD, CAT and GSH-Px activity (p < 0.05), down-regulated Bax and Caspase-3 gene expressions (p < 0.05), and up-regulated the gene expressions of ZO-1, Claudin-1, Occludin, catalase, glutathione GPX1, SOD1, HO-1, NQO1 and Nrf2, compared with the single H<sub>2</sub>O<sub>2</sub>–induced cells. …”
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19272
Strategy parameters across development for male mice in set size = 2 and set size = 4 from winning computational model.
Published 2024“…Both parameters S1 “Inappropriate Lose-Shift” and S3 “Inappropriate Lose-Stay” decreased significantly with age in set size = 2 (C: <i>p</i> = 0.02, E: <i>p</i> = 0.04), but not in set size = 4 (H,J). …”
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19273
Table 1_Protective effects of soybean peptides on H2O2-induced oxidative injury in IPEC-J2 cells.docx
Published 2024“…However, pretreatment with SBP followed by H<sub>2</sub>O<sub>2</sub> inducement significantly increased cell viability to 72.99%, decreased cell apoptosis, increased SOD, CAT and GSH-Px activity (p < 0.05), down-regulated Bax and Caspase-3 gene expressions (p < 0.05), and up-regulated the gene expressions of ZO-1, Claudin-1, Occludin, catalase, glutathione GPX1, SOD1, HO-1, NQO1 and Nrf2, compared with the single H<sub>2</sub>O<sub>2</sub>–induced cells. …”
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19274
Image 1_Protective effects of soybean peptides on H2O2-induced oxidative injury in IPEC-J2 cells.jpeg
Published 2024“…However, pretreatment with SBP followed by H<sub>2</sub>O<sub>2</sub> inducement significantly increased cell viability to 72.99%, decreased cell apoptosis, increased SOD, CAT and GSH-Px activity (p < 0.05), down-regulated Bax and Caspase-3 gene expressions (p < 0.05), and up-regulated the gene expressions of ZO-1, Claudin-1, Occludin, catalase, glutathione GPX1, SOD1, HO-1, NQO1 and Nrf2, compared with the single H<sub>2</sub>O<sub>2</sub>–induced cells. …”
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19275
Table 1_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.xlsx
Published 2025“…</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …”
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19276
Table 6_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.xlsx
Published 2025“…</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …”
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19277
Image 7_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.tif
Published 2025“…</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …”
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19278
Table 7_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.xlsx
Published 2025“…</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …”
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19279
CONSORT Flowchart of Participants.
Published 2025“…The intervention group showed significantly reduced weight (median; baseline 1, post-intervention 0.975, follow-up 0.983, p < 0.001), and slightly reduced waist circumference (median; baseline 1, post-intervention 0.975, follow-up 0.975, p = 0.226); however, the control group showed no change. …”
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19280
Image 10_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.tif
Published 2025“…</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …”