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significant cause » significant change (Expand Search), significant changes (Expand Search), significant gap (Expand Search)
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18941
The efficacy of metformin in counteracting olanzapine-induced hyperprolactinemia: an open-label prospective study
Published 2025“…</p> <p>After eight weeks of metformin intervention, prolactin levels significantly decreased from 39.7 ± 20.0 ng/mL at baseline to 35.7 ± 15.7 ng/mL (<i>p</i> = 0.005) with a moderate effect size (Cohen’s <i>d</i> = 0.545). …”
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18942
Data Sheet 1_NLRP3 regulates epithelial barrier integrity and protects from airway hyperresponsiveness in experimental allergic asthma.pdf
Published 2025“…Analysis of epithelial cell markers revealed decreased gene expression of the tight junction proteins Cld-18 and Tjp-1, and decreased expression of the epithelial transmembrane protein E-cadherin in the lungs of naïve NLRP3<sup>-/-</sup> mice compared to WT mice. …”
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18943
Table 1_Evaluating the prognostic relevance of neutrophil-to-lymphocyte ratio in cervical cancer: a systematic review and meta-analysis.docx
Published 2024“…</p>Conclusion<p>An elevated NLR prior to treatment demonstrates a strong association with decreased OS and PFS among patients with cervical cancer, underscoring the significance of NLR as a prognostic marker within this population.…”
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18944
Supplementary file 1_Global, regional, and national burdens of congenital heart anomalies from 1990 to 2021, and projections to 2050.xlsx
Published 2025“…Background<p>Congenital heart anomalies (CHAs) are the most prevalent birth defects, significantly impacting pediatric populations and healthcare systems worldwide. …”
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18945
Data Sheet 4_Global, regional, and national burdens of congenital heart anomalies from 1990 to 2021, and projections to 2050.pdf
Published 2025“…Background<p>Congenital heart anomalies (CHAs) are the most prevalent birth defects, significantly impacting pediatric populations and healthcare systems worldwide. …”
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18946
Data Sheet 7_Global, regional, and national burdens of congenital heart anomalies from 1990 to 2021, and projections to 2050.pdf
Published 2025“…Background<p>Congenital heart anomalies (CHAs) are the most prevalent birth defects, significantly impacting pediatric populations and healthcare systems worldwide. …”
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18947
Data Sheet 1_Identification of telomere-related gene subtypes and prognostic signatures in osteosarcoma.xlsx
Published 2025“…Finally, we discovered that expression of PDK2, PPARG, MORC4, SP110, TERT and MAP3K5 was significantly decreased in OS cells.</p>Conclusion<p>In conclusion, our study has uncovered the importance of TRGs in defining distinct subtypes of OS with different survival outcomes and immune contexts. …”
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18948
Data Sheet 3_Global, regional, and national burdens of congenital heart anomalies from 1990 to 2021, and projections to 2050.pdf
Published 2025“…Background<p>Congenital heart anomalies (CHAs) are the most prevalent birth defects, significantly impacting pediatric populations and healthcare systems worldwide. …”
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18949
Data Sheet 2_Global, regional, and national burdens of congenital heart anomalies from 1990 to 2021, and projections to 2050.pdf
Published 2025“…Background<p>Congenital heart anomalies (CHAs) are the most prevalent birth defects, significantly impacting pediatric populations and healthcare systems worldwide. …”
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18950
<b>Data for opposing effects</b><b> of maize straw and its biochar on soil N</b><sub><strong>2</strong></sub><b>O emissions</b><b> </b><b>by mediating microbial nitrification and d...
Published 2025“…<p dir="ltr">Application of straw and biochar has been shown to significantly affect greenhouse gas emissions from soil. …”
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18951
Table 1_Multi-omics reveals total flavones from Abelmoschus manihot (L.) Medik. [Malvaceae] ameliorate MAFLD via PI3K/AKT/mTOR-mediated autophagy.docx
Published 2025“…In MAFLD mice, TFA treatment significantly decreased body weight gain, hepatic lipid accumulation, and the serum levels of ALT, AST, TC, and TG. …”
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18952
Participants baseline characteristics.
Published 2025“…The clinical trial’s results showed that MMF treatment had a positive effect on the improvement of BMD in the lumbar spine and increased serum P1NP levels while decreased β-CTX levels. In addition, MMF treatment decreased participants’ VAS scores for low back pain.…”
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18953
Table 2_Multi-omics reveals total flavones from Abelmoschus manihot (L.) Medik. [Malvaceae] ameliorate MAFLD via PI3K/AKT/mTOR-mediated autophagy.docx
Published 2025“…In MAFLD mice, TFA treatment significantly decreased body weight gain, hepatic lipid accumulation, and the serum levels of ALT, AST, TC, and TG. …”
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18954
Flowchart of the clinical trial.
Published 2025“…The clinical trial’s results showed that MMF treatment had a positive effect on the improvement of BMD in the lumbar spine and increased serum P1NP levels while decreased β-CTX levels. In addition, MMF treatment decreased participants’ VAS scores for low back pain.…”
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18955
<b>Effects of resveratrol supplementation on performance and metabolic adaptations in heat-stressed Holstein cows during early lactation–A preliminary study</b>
Published 2025“…Serum non-esterified fatty acids and insulin levels, and aspartate aminotransferase activity decreased significantly, while glucose level and alanine aminotransferase activity showed a downward trend. …”
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18956
Protective role of <i>N</i>-acetyl-l-tryptophan against hepatic ischemia-reperfusion injury via the RIP2/caspase-1/IL-1β signaling pathway
Published 2024“…Similarly, IL-1β activity and caspase-1 activity were significantly decreased in the H<sub>2</sub>O<sub>2</sub> group when compared with the controls, after l-NAT intervention.…”
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18957
The Gigante Litter Manipulation Experiment
Published 2024“…Soil nitrate and nitrogen (N) concentrations in roots and leaves decreased quickly and significantly with litter removal (LR) and increased quickly and significantly with litter addition (LA). …”
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18958
Cows' BHB impacts on calf BAT growth and metabolic health
Published 2025“…The results showed that although high BHB levels had no effect on calf birth weight or growth, they significantly impaired glucose sensitivity, increased stress genes and decreased brown adipose tissue mass, thermogenic proteins and mitochondrial density. …”
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18959
The effects of CHRM2 knockdown on osteogenic differentiation and cell proliferation.
Published 2025“…(B) The RT-qPCR results showed that the expression of CHRM2 in cells with Si-CHRM2 knockdown decreased significantly. (C) The cell proliferation were measured by OD value at 450 nm, and the observation time points were at 0, 24, 48, 72 and 96 hours. …”
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18960
Image 2_Profiling of small RNAs derived from tomato brown rugose fruit virus in infected Solanum lycopersicum plants by deep sequencing.jpeg
Published 2025“…Seven potential target genes were selected for qRT-PCR analysis, confirming that their transcript accumulation significantly decreased in the leaves of tomato plants infected with ToBRFV. …”