POriginal blots. حسب Li-Hong Chen (610826)

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Identification of tryptophan metabolism-related gene CYP1B1 in sepsis. حسب Li-Hong Chen (610826)

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PTable S4 Expression validation of CYP1B1. حسب Li-Hong Chen (610826)

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PTable S2 Differentially expressed genes. حسب Li-Hong Chen (610826)

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The transfection efficiency of CYP1B1 knockdown in THP-1 cells. حسب Li-Hong Chen (610826)

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Knockdown of CYP1B1 inhibited monocytes activation and tryptophan metabolism. حسب Li-Hong Chen (610826)

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PTable S5 Markers of each cell cluster. حسب Li-Hong Chen (610826)

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The specific expression of CYP1B1 were explored in different cell types at single-cell level. حسب Li-Hong Chen (610826)

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Validation of CYP1B1 expression in THP-1 monocytes. حسب Li-Hong Chen (610826)

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Original uncropped Western blot images. حسب Yaping Yuan (2734228)

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Trends of incident opioid users, L-TOT users, and L-TOT discontinuers between 2009 and 2013. حسب Qian Cai (112039)

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The yearly numerator, denominator and rate of incident opioid users, L-TOT users and L-TOT discontinuers from 2009 to 2019. حسب Qian Cai (112039)

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Incidence rate ratios of negative binominal regression models for yearly rates of incident opioid users, L-TOT users and L-TOT discontinuers during 2009–2013 and 2015–2019. حسب Qian Cai (112039)

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Demographic, comorbidity, concurrent drug, and opioid characteristics, among L-TOT users and L-TOT discontinuers between 2009–2019. حسب Qian Cai (112039)

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Contains R code utilized in the analyses. حسب Arttu Autio-Kimura (20454681)

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Sex-based differences for combinations of brain regions and cell types, based on Mann-Whitney U-test. حسب Arttu Autio-Kimura (20454681)

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Bootstrapped spearman correlations from a randomly selected subset of male sample donor originating samples (n = 493). حسب Arttu Autio-Kimura (20454681)

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Spearman correlations between the age of the sample donor (20–70 years) and estimated proportions of neuronal, glial, and endothelial cells. حسب Arttu Autio-Kimura (20454681)

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Box plots for subsets of female originating samples, displaying the distributions of the proportions of neuronal, glial, and endothelial cells. حسب Arttu Autio-Kimura (20454681)

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Box plots for subsets of male originating samples, displaying the distributions of the proportions of neuronal, glial, and endothelial cells. حسب Arttu Autio-Kimura (20454681)

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