Image 2_Hypothalamic FTO upregulates BDNF to promote GnRH expression through the PI3K/Akt pathway, leading to precocious puberty.tif حسب Shaolian Zang (11987905)

"…</p>Results<p>Hypothalamic GnRH and FTO expression progressively increased whereas m6A methylation decreased during puberty. MeRIP-seq revealed significantly reduced m6A methylation of Bdnf mRNA in the arcuate nucleus (ARC) of female rats during early puberty. …"

Image 1_Hypothalamic FTO upregulates BDNF to promote GnRH expression through the PI3K/Akt pathway, leading to precocious puberty.tif حسب Shaolian Zang (11987905)

"…</p>Results<p>Hypothalamic GnRH and FTO expression progressively increased whereas m6A methylation decreased during puberty. MeRIP-seq revealed significantly reduced m6A methylation of Bdnf mRNA in the arcuate nucleus (ARC) of female rats during early puberty. …"

Data Sheet 1_Differential regulation of soil microecology in crop rotation systems of maize, seed pumpkin, and processing tomato.docx حسب Xingxing Liu (715957)

"…Notably, the SLa treatment significantly decreased soil total potassium content by 13.6%. …"

Analysis of errors of the AI model on accuracy and decision times for different tasks during the retrospective reader study. (a) حسب Kerol Djoumessi (21349992)

"…When the AI model is correct, the explanation decreases decision time significantly, while it does not increase the decision time for incorrect decisions.…"

Image 2_A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation.jpeg حسب Zebanuer Yuemaierjiang (22702064)

"…Mechanistically, β-PGG decreased PCID2 expression and downregulated Cyclin D1 and CDK6. …"

Supplementary file 1_A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation.docx حسب Zebanuer Yuemaierjiang (22702064)

"…Mechanistically, β-PGG decreased PCID2 expression and downregulated Cyclin D1 and CDK6. …"

Image 1_A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation.png حسب Zebanuer Yuemaierjiang (22702064)

"…Mechanistically, β-PGG decreased PCID2 expression and downregulated Cyclin D1 and CDK6. …"

Supplementary Material for: Hemispherotomy for Drug-Resistant Epilepsy in a Low-resource Setting: Surgical Outcomes and Quality of Life in 23 Children Treated in a Hybrid Program i... حسب figshare admin karger (2628495)

"…Introduction: Hemispherotomy is an effective treatment for children with drug-resistant epilepsy (DRE). …"

DataSheet1_The impact of statin use on short-term and long-term mortality in patients with heart failure.docx حسب Xiaoxue Zheng (433886)

"…Low-dose statins can significantly reduce short-term and long-term mortality, while high-dose statins are not significantly correlated with mortality. …"

DataSheet1_Slow-release nitrogen fertilizer application regulated rhizosphere microbial diversity to increase maize yield.docx حسب Tiantian Meng (4508569)

"…The results showed that nitrogen application increased the diversity of bacteria, and nitrogen application significantly increased the diversity of rhizosphere bacteria and fungi due to rhizosphere effects. …"

Data Sheet 1_Cohort analysis of high-risk HPV infection in adult women in Dapeng New District, Shenzhen, Guangdong Province, China.pdf حسب Weifeng Wei (1515805)

"…Large-scale HPV screening is crucial for early detection, as appropriate intervention in HPV-positive individuals can significantly reduce cervical cancer incidence and mortality.…"

Table 1_Prevalence and prognostic value of sarcopenia in patients with bladder cancer undergoing radical cystectomy: a systematic review and meta-analysis.docx حسب Lei Zhang (38117)

"…</p>Objectives<p>This study was conducted to systematically evaluate the prognostic significance of sarcopenia in patients with bladder cancer undergoing RC.…"

Data Sheet 1_Therapeutic potential of Cordyceps militaris cultivated with Ginkgo biloba seeds for alleviating western diet-induced type 2 diabetes and diabetic nephropathy.pdf حسب Shinn-Zong Lin (217003)

"…Key biochemical markers, including blood glucose, triglycerides, cholesterol, blood urea nitrogen (BUN), and creatinine, were significantly improved after treatment. Histopathologic analysis revealed restored renal morphology, reduced fibrosis and decreased amyloid deposition. …"

Table 1_Characteristics and trends of unintentional injuries among children and adolescents in Kunshan, China: a hospital-based retrospective study, 2018–2023.docx حسب Li Shen (110858)

"…Unintentional injury cases decreased significantly during COVID-19 (2020–2022). …"

Data Sheet 1_Silica nanoparticles alleviate cadmium toxicity to Pisum sativum L. seedling growth by remodeling carbon-nitrogen metabolism.docx حسب Xiaohuan Yang (3697462)

"…<p>The increasing incidence of soil cadmium (Cd) pollution significantly hinders the sustainable development of agriculture and food security. …"

High-throughput single-cell analysis reveals Omp38-specific monoclonal antibodies that protect against <i>Acinetobacter baumannii</i> infection حسب Yiwei Zhang (1448599)

"…Intravenous administration of the Omp38-specific mAbs significantly improved the survival rate and reduced the bacterial load in a mouse model of lethal <i>A. baumannii</i> infection. …"

JAK/STAT signaling promotes high global translation rates in CySCs. حسب Ruoxu Wang (9312306)

"…(C, C′) A wild-type testis showing highest OPP in CySCs adjacent to the hub and decreasing OPP levels with increasing distance from the hub. …"

Supplementary file 1_Identifying early blood glucose trajectories in sepsis linked to distinct long-term outcomes: a K-means clustering study with external validation.docx حسب Huan Ma (713125)

"…Conversely, patients with a “high-stable” trajectory (HR: 1.61, 95% CI: 1.35-1.92, P < 0.001) and those exhibiting unstable trends had significantly higher mortality risks (“high-decreasing”, HR: 1.38, 95% CI: 1.16-1.65, P < 0.001; “moderate-increasing”, HR: 1.37, 95% CI: 1.18-1.60, P < 0.001). …"

Data Sheet 1_A novel short-course, low-intensity blood-flow-restricted exercise (BFRE) regimen to study satellite cell function in critical illness survivors with sustained muscle... حسب Sunita Mathur (759075)

"…In controls, satellite cell content and MuRF1 transcript expression were significantly higher (1.53 ± 0.30- and 1.34 ± 0.31-fold difference, respectively) and myostatin transcript expression was significantly lower (0.58 ± 0.31-fold difference) in BFRE-trained versus untrained VL. …"

Table 1_Resveratrol targeting MDM2/P53/PUMA axis to inhibit colonocyte apoptosis in DSS-induced ulcerative colitis mice.xlsx حسب Rui Tang (298719)

"…</p>Results<p>Resveratrol treatment effectively repaired colonic damage in the UC mouse model by significantly increasing colon length, reducing inflammatory cell infiltration, and mitigating mucosal injury. …"