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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
significant based » significant cause (Expand Search), significant barrier (Expand Search), significant burden (Expand Search)
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18781
Table 1_Danggui Buxue Decoction attenuates 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone—induced lung cancer growth in A/J mice by suppressing HIF-1α/VEGF-mediated angiogenesis.do...
Published 2025“…By week 20, progressive multifocal opacities emerged alongside reduced pulmonary artery flow, impaired lung function, elevated TNF-α/VEGF, and decreased WBC, lymphocytes, and platelets. Compared to untreated controls, 10-week DBD treatment significantly suppressed lung tumor growth, reduced lesion microvessel density, downregulated HIF-1α and VEGF expression, and ameliorated hematological dysregulation.…”
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18782
Table 1_Effect of compound kushen injection on immune function in patients with colorectal cancer: a systematic review and meta-analysis.docx
Published 2025“…Chemotherapy and radiotherapy remain cornerstone treatments; however, they often lead to significant immune suppression and an increased risk of infection. …”
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18783
Supporting data for <b>Drivers, Composition and Potential for Innovative Vector Control Approaches in the mosquito</b>
Published 2025“…While most Bacteria and Viruses studied showed correlations with decreased immune gene expression, some, such as Doliuvirus or Siphonobacter, were associated with increased immune gene expression. …”
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18784
Data Sheet 1_A longitudinal study on perceived burdensomeness and its influencing factors among older adult hemodialysis patients who migrated with their families in China.pdf
Published 2025“…The family support scores showed a gradually decreasing trend (T1: 10.25 ± 1.91, T2: 9.70 ± 1.84, and T3: 9.13 ± 1.88). …”
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18785
Uncovering the mechanistic basis of <i>Rheum palmatum</i> L. (rhubarb) in the treatment of chronic kidney disease: an integrative approach using network pharmacology, molecular doc...
Published 2025“…MR analysis demonstrated a statistically significant causal association between TNF and CKD (OR = 1.02, <i>p</i> < 0.05), with positive trends for IL6 and CASP3. …”
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18786
Image 2_Restoring natural killer cell activity in lung injury with 1,25-hydroxy vitamin D3: a promising therapeutic approach.jpeg
Published 2025“…Isolated lung trNK cells of the ALI mice exhibited reduced CD107a and NKp46 markers and cytotoxicity potentials and were correlated through significantly 2.1-fold higher levels of PD-1 and diminished VDR expressions as compared to naïve mice. …”
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18787
Repetitive stress modulates loudness perception.
Published 2025“…Mice exhibited increased perceptual boundaries during repeated stress, indicating a decreased loudness perception (<i>t</i> test, <i>p</i> = 1.2 × 10<sup>−05</sup>, mean ± SE). …”
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18788
Data Sheet 1_Real world evidence of dupilumab effectiveness in a Colombian cohort of patients diagnosed with severe asthma.docx
Published 2025“…FEV<sub>1</sub>pp showed higher but not significant values from the 2–4-month period, with a median change of 12.5% (IQR: 0.3, 21.5). …”
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18789
Image 3_Restoring natural killer cell activity in lung injury with 1,25-hydroxy vitamin D3: a promising therapeutic approach.jpeg
Published 2025“…Isolated lung trNK cells of the ALI mice exhibited reduced CD107a and NKp46 markers and cytotoxicity potentials and were correlated through significantly 2.1-fold higher levels of PD-1 and diminished VDR expressions as compared to naïve mice. …”
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18790
Table 1_Restoring natural killer cell activity in lung injury with 1,25-hydroxy vitamin D3: a promising therapeutic approach.docx
Published 2025“…Isolated lung trNK cells of the ALI mice exhibited reduced CD107a and NKp46 markers and cytotoxicity potentials and were correlated through significantly 2.1-fold higher levels of PD-1 and diminished VDR expressions as compared to naïve mice. …”
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18791
Correlation analyses between studied genes.
Published 2024“…</p><p>Conclusions</p><p>Our study is the first to detect decreased <i>NEAT-1</i> and <i>miR374b-5p</i> expression in COVID-19 patients’ serum. …”
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18792
Table1_Clinical efficacy of Fufang Yinhua Jiedu (FFYH) granules in mild COVID-19 and its anti-SARS-CoV-2 mechanism by blocking autophagy through inhibiting the AKT/mTOR signaling p...
Published 2024“…</p>Conclusion<p>Our results indicate that FFYH not only has good anti-viral activity against SARS-CoV-2 but also has significant efficacy against COVID-19, indicating that FFYH may be a novel complementary option for treating COVID-19.…”
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18793
Table 1_Studies on fatty acids and microbiota characterization of the gastrointestinal tract of Tianzhu white yaks.docx
Published 2025“…Introduction<p>The gut microbiota significantly influences the host’s production performance and health status, with different gastrointestinal tissues exhibiting functional diversity reflected in their microbial diversity.…”
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18794
AjMLKL is involved in 10<sup>8</sup> CFU/mL AJ01 induced lytic coelomocyte death independent on its phosphorylation.
Published 2025“…Coelomocyte viability was significantly increased (L), and coelomocytes plasma membrane disruption (M) and the percentage of Annexin V+/PI+ coelomocytes significantly decreased (N). …”
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18795
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18796
Data Sheet 1_CD226+ B cells in primary Sjögren’s syndrome: a key player in clinical manifestations and disease pathogenesis.docx
Published 2025“…</p>Results<p>CD226 expression in the peripheral blood of pSS patients was significantly increased on T cells, CD19<sup>+</sup> B cells and CD14<sup>+</sup> monocytes, but significantly decreased on CD56<sup>+</sup> NK cells.We identified a distinct CD226<sup>+</sup>CD19<sup>+</sup> B cell subset that exhibited pathogenic features in pSS. …”
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18797
Table2_Clinical efficacy of Fufang Yinhua Jiedu (FFYH) granules in mild COVID-19 and its anti-SARS-CoV-2 mechanism by blocking autophagy through inhibiting the AKT/mTOR signaling p...
Published 2024“…</p>Conclusion<p>Our results indicate that FFYH not only has good anti-viral activity against SARS-CoV-2 but also has significant efficacy against COVID-19, indicating that FFYH may be a novel complementary option for treating COVID-19.…”
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18798
Effects of extracorporeal shock wave therapy on motor function in patients with cerebral palsy: a systematic review and meta-analysis
Published 2025“…In addition, spasticity significantly decreases, particularly with focused ESWT or ESWT targeting the upper limbs.…”
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18799
SNAP-25 (1-197) binds to syntaxin-1A, and the interaction is enhanced by Ser187 phosphorylation.
Published 2025“…<b>(C and D)</b> PMA treatment further decreases neurotransmitter release when a low level of SNAP-25 cleavage is present. …”
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18800
Data Sheet 1_The efficacy and safety of panax quinquefolius saponin for heart failure: a systematic review and meta-analysis.pdf
Published 2025“…The results of a meta-analysis under a random-effects model showed that adjuvant PQS therapy significantly increased LVEF (MD = 6.23, 95% CI [4.35, 8.12], P < 0.00001), 6MWTD (MD = 25.26, 95% CI [8.23, 42.30], P = 0.004), and decreased BNP/NT-pro-BNP (MD = −187.94, 95% CI [−267.20, −108.67], P < 0.00001), LVEDV (MD = −22.83, 95% CI [−42.79, −2.87], P = 0.02), LVEDD (MD = −4.76, 95% CI [−5.77, −3.74], P < 0.00001), and LVESV (MD = −11.86, 95% CI [−19.89, −3.83], P = 0.004) in patients with HF.…”