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significant effect » significant impact (Expand Search)
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20481
Data Sheet 1_Desulfovibrio vulgaris exacerbates sepsis by inducing inflammation and oxidative stress in multiple organs.pdf
Published 2025“…Phosphorylation of MAPK and NF-κB pathways in peritoneal macrophages was significantly enhanced. Additionally, D. vulgaris amplified oxidative stress across multiple organs, as indicated by increased ROS levels and decreased antioxidant enzyme activity.…”
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20482
Table 1_Downregulation of HDGF inhibits tumorigenic phenotypes of hypopharyngeal squamous cell carcinoma by suppressing the AKT/mTOR/VEGF pathway.xlsx
Published 2025“…In FaDu HSCC cells, siRNA-mediated HDGF knockdown significantly attenuated proliferation, migration, and invasion. …”
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20483
Table 1_Regional and age-specific global trends associated with infectious diarrhea in children under 14 years old caused by pathogenic microorganisms in 2021.docx
Published 2025“…</p>Conclusion<p>Although the global burden of diarrhea has decreased significantly, it is still high in low-income countries and low- and medium-SDI areas, and newborns are at high risk. …”
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20484
Supplementary Material for: Comparing Two Oral Immunotherapy Strategies for Sesame Allergy: Baked Goods with Sesame Paste Versus Crushed Sesame Seeds
Published 2025“…For both the baked goods and the seeds group, likelihood of severe reactions significantly decreased over time. Conclusion: A modified sesame desensitization protocol using baked sesame paste can be safely used in children with sesame allergy.…”
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20485
Table 6_Global, regional and national burden of traumatic amputations from 1990 to 2021: a systematic analysis of the Global Burden of Disease study 2021.docx
Published 2025“…However, the change in age-standardized rates from 1990 to 2021 declined significantly. The association between the Socio-demographic Index (SDI) and the burden of amputations in 2021 was not linear. …”
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20486
Data Sheet 1_The pan-cancer landscape of aldo-keto reductase1B10 reveals that its expression is diminished in gastric cancer.docx
Published 2024“…In tumor microenvironment, AKR1B10 was significantly correlated with immune cell infiltrations and immune gene expression. …”
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20487
Image 3_A putative glucose-1-phosphate thymidylyltransferase is required for virulence, membrane-associated mechanisms, and tolerance to external stresses in Acidovorax citrulli.ti...
Published 2025“…Notably, the mutant was highly susceptible to multiple stress conditions—including ethylenediaminetetraacetic acid, acetic acid, cupric chloride, sodium dodecyl sulfate, and pH stress—as indicated by significantly decreased OD values or colony forming units (CFUs) compared to the wild type. …”
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20488
Differences in lesion development of slow- and fast-growing meat-type chickens after experimental challenge with <i>Enterococcus cecorum</i>
Published 2025“…Extra-intestinal colonization with EC at 43/44 dph was significantly reduced in group ESG compared to EFG (<i>P</i> < 0.05). …”
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20489
Image 3_HIF‐1α modulates pancreatic cancer ECM proteins via the TGF‐β1/Smad signaling pathway introduction.tif
Published 2025“…Pharmacological inhibition of either HIF-1α or TGF-β1 significantly decreased the expression of ECM proteins, while TGF-β1 stimulation enhanced their production. …”
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20490
Defective autophagy in vascular smooth muscle cells promote uremic accelerated atherosclerosis
Published 2025“…<p>Individuals with chronic kidney disease (CKD) exhibit a significantly elevated risk of premature mortality, predominantly attributable to cardiovascular etiologies. …”
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20491
Natural selection diagram.
Published 2025“…Additionally, the variation in node utilization rates significantly decreased from 30.1% to 12.25%, markedly enhancing resource scheduling efficiency and overall balance within the supply chain.…”
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20492
Improved optimization results.
Published 2025“…Additionally, the variation in node utilization rates significantly decreased from 30.1% to 12.25%, markedly enhancing resource scheduling efficiency and overall balance within the supply chain.…”
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20493
Algorithm training accuracy experiments.
Published 2025“…However, after removing the integrated residual attention unit and depth-wise separable convolution, the accuracy decreased by 1.91% and the latency increased by 117ms. …”
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20494
<b>Empagliflozin reduces left ventricular mass increase and improves cardiomyocyte hypertrophy after 5/6 nephrectomy.</b>
Published 2025“…Single-nuclei RNA sequencing (snRNA-seq) and quantitative real-time polymerase chain reaction (qRT-PCR) were employed to investigate molecular mechanisms. 5/6 nephrectomy increased serum creatinine, troponin T, LVM, ejection fraction, and cardiomyocyte diameter. Empagliflozin significantly reduced LVM and cardiomyocyte hypertrophy, comparable to Telmisartan. …”
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20495
Table 2_Long-term outcomes of platinum-based chemotherapy for T4 stage sinonasal adenoid cystic carcinoma.docx
Published 2025“…Besides, chemotherapy significantly decreased 10-year OS (27.9% vs. 58.8%, P = 0.034) compared with the no-chemotherapy group. …”
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20496
Table 1_Long-term outcomes of platinum-based chemotherapy for T4 stage sinonasal adenoid cystic carcinoma.doc
Published 2025“…Besides, chemotherapy significantly decreased 10-year OS (27.9% vs. 58.8%, P = 0.034) compared with the no-chemotherapy group. …”
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20497
Gene comparison map before and after mutation.
Published 2025“…Additionally, the variation in node utilization rates significantly decreased from 30.1% to 12.25%, markedly enhancing resource scheduling efficiency and overall balance within the supply chain.…”
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20498
The evolution of inharmonicity and noisiness in contemporary popular music
Published 2025“…From 1961 to 1972, inharmonicity in popular music, initially only slightly higher than in orchestral music, increased significantly. Between 1972 and 1986, this rise in inharmonicity was accompanied by an increase in noise, but since 1986, both inharmonicity and noise have moderately decreased. …”
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20499
Recombinant gene map.
Published 2025“…Additionally, the variation in node utilization rates significantly decreased from 30.1% to 12.25%, markedly enhancing resource scheduling efficiency and overall balance within the supply chain.…”
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20500
Regional differences in cholinergic sweating in the lower limb
Published 2025“…These reductions were primarily attributable to decreases in sweat gland output, rather than changes in activated sweat gland density. …”