يعرض 21,081 - 21,100 نتائج من 21,342 نتيجة بحث عن '(( significant decrease decrease ) OR ( ((significant genes) OR (significant changes)) decrease ))', وقت الاستعلام: 0.56s تنقيح النتائج
  1. 21081

    Table 1_Polygonatum cyrtonema Hua polysaccharides alleviate muscle atrophy and fat lipolysis by regulating the gut microenvironment in chemotherapy-induced cachexia.docx حسب Rongrong Zhou (3341903)

    منشور في 2025
    "…</p><p>Results: This study demonstrated that PCPs significantly mitigated body weight loss, restored muscle fiber atrophy and mitochondrial disorder, alleviated adipose tissue wasting, strengthened the intestinal barrier integrity, and decreased the intestinal inflammation in chemotherapy-induced cachexia. …"
  2. 21082

    Image 3_Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma.tif حسب Rong Su (2210740)

    منشور في 2025
    "…In vitro, the overexpression of miR-4739 in Huh-7 cells significantly induced SPP1<sup>+</sup> macrophages, and the culture medium derived from SPP1<sup>+</sup> macrophages further promoted the proliferation and migration of Huh-7 cells. …"
  3. 21083

    Fig 3 - حسب Nehal Shawky Nagy (17721213)

    منشور في 2024
    "…Different superscripts on the columns are significantly different at p≤0.05.</p>…"
  4. 21084

    Image 2_Metformin attenuates alveolar bone destruction in mice with apical periodontitis and inhibits pro-inflammatory cytokine synthesis in lipopolysaccharide-stimulated RAW264.7... حسب Chunmei Ren (10921089)

    منشور في 2025
    "…</p>Results<p>Metformin significantly reduced periapical bone destruction on postoperative days 21 and 28, and decreased the number of osteoclasts on the periapical alveolar bone on postoperative day 28. …"
  5. 21085

    Image 1_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.png حسب Feifei Yang (334047)

    منشور في 2025
    "…Functionally, iron overload decreased the phagocytic function of LAMs against leukemia cells and inhibited LAM-induced T cell activation by acquiring a tolerogenic phenotype with aberrant immune checkpoints. …"
  6. 21086

    Association of Patient Cost-Sharing with Adherence to GLP-1a and Adverse Health Outcomes حسب Donglan Zhang (702608)

    منشور في 2025
    "…Results Among 61,907 adults initiated GLP-1a, higher 30-day OOP costs were associated with decreased adherence. Patients in the highest OOP cost quartile (Q4: $80–$3,375) had significantly higher odds of non-adherence (OR: 1.25; 95% CI: 1.19–1.31) compared to those in the lowest quartile (Q1: $0–$21). …"
  7. 21087

    DataSheet1_DYNLT3 overexpression induces apoptosis and inhibits cell growth and migration via inhibition of the Wnt pathway and EMT in cervical cancer.pdf حسب Jianan Zhang (786459)

    منشور في 2025
    "…Up-regulation of DYNLT3 expression significantly inhibited tumor growth in a nude mouse model, while downregulation of DYNLT3 showed the opposite results. …"
  8. 21088

    Image 2_Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma.tif حسب Rong Su (2210740)

    منشور في 2025
    "…In vitro, the overexpression of miR-4739 in Huh-7 cells significantly induced SPP1<sup>+</sup> macrophages, and the culture medium derived from SPP1<sup>+</sup> macrophages further promoted the proliferation and migration of Huh-7 cells. …"
  9. 21089

    Image 1_Plant-based diets and total and cause-specific mortality: a meta-analysis of prospective studies.tif حسب Qiwang Mo (9091292)

    منشور في 2025
    "…Participants in the highest quintile of both the PDI and hPDI had a significantly decreased risk of all-cause mortality (pooled HR<sub>PDI</sub> = 0.85; 95% CI: 0.80–0.90; pooled HR<sub>hPDI</sub> = 0.86; 95% CI: 0.81–0.92) compared to participants in the lowest quintile. …"
  10. 21090

    Image 1_The immunomodulatory and antitumor properties of the bacterial metalloprotease Oligopeptidase A are mediated by TLR4/MyD88/TRIF and MAPK signaling pathways.tif حسب Priscila Silva (556743)

    منشور في 2025
    "…</p>Results<p>Heat-inactivated OpdA significantly reduced metastasis, dependent on tumor-specific CD4+ and CD8+ T cells and IFN-γ, both locally and systemically, with decreased IL-10 levels suggesting a proinflammatory environment. …"
  11. 21091

    Image 5_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.png حسب Feifei Yang (334047)

    منشور في 2025
    "…Functionally, iron overload decreased the phagocytic function of LAMs against leukemia cells and inhibited LAM-induced T cell activation by acquiring a tolerogenic phenotype with aberrant immune checkpoints. …"
  12. 21092

    Image 4_Establishment and validation of survival nomogram score staging for esophageal squamous cell carcinoma patients after minimally invasive surgery combined with immune progno... حسب Shao-jun Xu (11633956)

    منشور في 2025
    "…Accordingly, we developed the SNS staging and found that the OS and DFS were significantly different among patients at different stages (all P < 0.001). …"
  13. 21093

    Data Sheet 1_Molecular insights into Atorvastatin’s role in delaying intervertebral disc degeneration.zip حسب Yupeng Li (507508)

    منشور في 2025
    "…</p>Results<p>Pretreatment with 10 μM atorvastatin significantly improved the survival rate of NPCs exposed to hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and reduced apoptosis. …"
  14. 21094

    Table 1_Seeds of success: seed biology and germination response of Gazania weed in Australia.xlsx حسب Muhammad Adnan (678952)

    منشور في 2025
    "…Seedling emergence and root length decreased with increasing burial depth and no emergence was observed at 6 cm depth. …"
  15. 21095

    Effects of extracts on body weight. حسب Srabonti Saha (17452756)

    منشور في 2025
    "…The results demonstrated that higher doses (200 mg) of <i>C. chinense</i> methanol extract inhibited immune responses, whereas lower doses helped restore them. The extracts significantly decreased pro-inflammatory mediators and cytokines in LPS-activated macrophages. …"
  16. 21096

    Image 2_The alteration of the sensorimotor network in trigeminal neuralgia after microvascular decompression surgery: a follow-up study using independent component analysis.tif حسب Yan Zhang (8098)

    منشور في 2025
    "…</p>Results<p>Compared to the HC, increased activity was observed in the right frontal operculum cortex, right insular cortex, right inferior frontal gyrus (pars opercularis), and right frontal pole in TN patients. Conversely, decreased activity was found in the right cerebellum (lobule IX) and left cerebellum (lobules VIII and IX). …"
  17. 21097

    Table 4_The effects of acute and chronic exercise on immune markers of TH1/TH2 cells in older adults: a systematic review.docx حسب Thiago Henrique Teodoro (20703731)

    منشور في 2025
    "…</p>Conclusion<p>Chronic exercise decreases serum TNF-α and IL-6 levels, lowers the CD4/CD8 ratio, and increases IL-10 after 24 weeks, aiding Th1 and Th2 balance. …"
  18. 21098

    Image 4_A metagenome-wide association study of gut microbiota in hepatitis B virus-related cirrhosis in northwest China.tif حسب Meirong Feng (22089665)

    منشور في 2025
    "…</p>Conclusion<p>HBV-LC patients in Northwest China exhibit altered clinical indicators, gut microbial composition (reduced diversity, increased opportunistic pathogens, decreased beneficial species), and metabolic function. …"
  19. 21099

    The composition of milk used with the treatment. حسب Srabonti Saha (17452756)

    منشور في 2025
    "…The results demonstrated that higher doses (200 mg) of <i>C. chinense</i> methanol extract inhibited immune responses, whereas lower doses helped restore them. The extracts significantly decreased pro-inflammatory mediators and cytokines in LPS-activated macrophages. …"
  20. 21100

    Data Sheet 1_Preparation of biosorbent from avocado seeds for preconcentration and simultaneous extraction of trace parabens in environmental wastewater samples.docx حسب Aluwani Sharon Nephiphidi (22696835)

    منشور في 2025
    "…The reusability and regeneration adsorption percentage recoveries significantly decreased after the fifth cycle. Parabens extraction using the 30% KOH- magnetic activated carbon was considered a capable biosorbent for the extraction of parabens because it demonstrated a strong potential for extracting parabens pollutants simultaneously in wastewater samples.…"