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significant genes » significant gender (Expand Search), significant benefits (Expand Search), significant changes (Expand Search)
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21301
Image 2_Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.tiff
Published 2025“…</p>Results<p>Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. …”
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21302
Table 2_Burden of hypertensive heart disease attributed to metabolic factors from 1990 to 2021 at global, regional, and national levels: an analysis of the global burden of disease...
Published 2025“…</p>Results<p>In 2021, deaths and DALYs due to HSBP and high BMI significantly increased compared to 1990. However, the ASMR for HSBP-related HHD [EAPC: −0.68; 95% confidence interval (CI): −0.77 to −0.58] and ASDR (EAPC: −0.90; 95% CI: −0.99 to −0.80) showed a decreasing trend, while the ASMR for BMI-related HHD (EAPC: 0.33; 95% CI: 0.27–0.39) and ASDR (EAPC: 0.15; 95% CI: 0.10–0.21) exhibited an increasing trend. …”
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21303
Image2_Comprehensive analysis of Hibisci mutabilis Folium extract’s mechanisms in alleviating UV-induced skin photoaging through enhanced network pharmacology and experimental vali...
Published 2024“…In vitro experiments showed that EHMF significantly reduced UV-induced inflammatory factors in HaCaT cells and improved cell survival rates. …”
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21304
RtcB cooperates with its cofactor Archease to promote axon regeneration.
Published 2025“…(D and E) Compared with <i>RtcB</i><sup><i>1-4B</i></sup> or <i>Archease</i><sup><i>PB</i></sup> heterozygotes, axon regeneration is significantly decreased in <i>RtcB</i> and <i>Archease</i> transheterozygotes. …”
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21305
DataSheet1_Comprehensive analysis of Hibisci mutabilis Folium extract’s mechanisms in alleviating UV-induced skin photoaging through enhanced network pharmacology and experimental...
Published 2024“…In vitro experiments showed that EHMF significantly reduced UV-induced inflammatory factors in HaCaT cells and improved cell survival rates. …”
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21306
Table 1_Assessment of various salt water stresses with mineralization on plant growth and antioxidants activity to regulate oxidative stress and ROS scavenging of halophyte ice pla...
Published 2025“…The results indicated that the T6 treatment (saline-alkali solution of 30 g/L) strongly decreased the plant height, stem thickness, leaf area and SPAD value of ice plants, and obviously suppressed the shoot and root biomass with the increase in salinity. …”
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21307
Image 5_Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.tiff
Published 2025“…</p>Results<p>Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. …”
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21308
Betulinic acid protects SH-SY5Y cells exposed to lipopolysaccharide and ferrous sulfate through p38MAPK/NF-κB/GPX4/Nrf2/keap-1/HO-1 signaling axis
Published 2025“…Furthermore, LPS and FeSO<sub>4</sub> significantly increased the expression of IL-6, TNF-α, and phosphorylation of p38, pMAPK, and pNFkB in the cells. …”
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21309
Mitigating toxicity of arsenic in sunflower (<i>Helianthus annuus</i> L.) with phosphate rock and farmyard manure using contrasting soil textures
Published 2025“…</p> <p></p><p>Arsenic solubility in soil significantly affected by soil texture, with clay soil exhibiting the least As availability followed by loam and sand texture.…”
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21310
Edaravone inhibits neuronal ferroptosis and alleviates acute Central nervous system injury induced by diquat <i>via</i> enhancement of METTL14-mediated m6A methylation of Aldh1l1
Published 2025“…Eda notably attenuated apoptosis, pro-inflammatory cytokines activation, and oxidative stress damage in diquat-induced rats. Eda significantly suppressed apoptosis, mitophagy and ferroptosis after diquat-stimulated PC12 cells. …”
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21311
DataSheet2_α-Mangostin Alleviated Inflammation in Rats With Adjuvant-Induced Arthritis by Disrupting Adipocytes-Mediated Metabolism-Immune Feedback.PDF
Published 2025“…Contrarily, MAN facilitated adipocyte differentiation in vitro, and increased free fatty acids production. It also significantly increased PPAR-γ and SCD-1 expression, which can be abrogated by PPAR-γ inhibitor T0070907. …”
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21312
Flow chart of the study participants.
Published 2025“…</p><p>Results</p><p>Bedside resuscitation increased significantly in the post-implementation period (9.3% versus 45.3%, <i>p</i> < 0.001 while early cord clamping decreased (26.7% versus 12.0%, <i>p</i> = 0.042). …”
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21313
DataSheet1_α-Mangostin Alleviated Inflammation in Rats With Adjuvant-Induced Arthritis by Disrupting Adipocytes-Mediated Metabolism-Immune Feedback.PDF
Published 2025“…Contrarily, MAN facilitated adipocyte differentiation in vitro, and increased free fatty acids production. It also significantly increased PPAR-γ and SCD-1 expression, which can be abrogated by PPAR-γ inhibitor T0070907. …”
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21314
Suggested modifications for the BabySaver.
Published 2025“…</p><p>Results</p><p>Bedside resuscitation increased significantly in the post-implementation period (9.3% versus 45.3%, <i>p</i> < 0.001 while early cord clamping decreased (26.7% versus 12.0%, <i>p</i> = 0.042). …”
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21315
Table 1_Demethylase FTO mediates m6A modification of ENST00000619282 to promote apoptosis escape in rheumatoid arthritis and the intervention effect of Xinfeng Capsule.docx
Published 2025“…</p>Results<p>Retrospective data mining demonstrated that XFC significantly improved immune-inflammatory markers in RA patients. …”
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21316
Data Sheet 1_Environmental surveillance of the health risk of PM2.5-bound metals and metalloids in Wuxi, China, from 2020 to 2023.docx
Published 2025“…Both PM<sub>2.5</sub> and most PM<sub>2.5</sub>-bound metals and metalloids exhibited decreasing trends to varying degrees and seasonal characteristics, peaking in winter. …”
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21317
Table 2_Isoenergetic reduction of dietary macronutrients affects body composition, physical activity, and post-prandial hormone responses in lean and obese cats fed to maintain bod...
Published 2025“…Post-prandial serum ghrelin decreased in all cats whereas serum peptide YY (PYY) increased at 1-, 2-, and 3-h post-prandial (P<sub>Time</sub> = 0.0094 and P<sub>Time</sub> = 0.0050). …”
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21318
Sound evoked cortical activity across vigilance states before and after NOE.
Published 2024“…Asterisks for panels <b>E-F</b> represent statistical significance p values *<0.05, **<0.01, ***<0.001 (GLMM). …”
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21319
<b>White</b><b>-shouldered starlings </b><b>prefer</b><b> nest boxes with smaller entrance to </b><b>avoid</b><b> nest usurpation</b>
Published 2025“…However, due to large areas of land being utilized for aquaculture and livestock farming, the availability of natural tree cavities in the area has significantly decreased. This scarcity of natural nest sites provided ideal experimental conditions for attracting birds using artificial nest boxes (see Liu et al., 2023). …”
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21320
Supplementary Material for: Words versus strands: Reliability and stability of concordance rates of self-reported and hair-analyzed substance use of young adults over time
Published 2024“…Underreporting of Ecstasy/MDMA, cocaine, ketamine, and opioid painkillers significantly increased. Contrarily, weekly to daily cannabis (31%/18%), amphetamine (95%/11%), and opioid painkiller use (12%/66%) were overreported. …”