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significant i » significant _ (Expand Search), significant 17 (Expand Search), significant anti (Expand Search)
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801
Table 1_Preliminary clinical activity of TP-0903 in relapsed or refractory acute myeloid leukemia with FLT3-ITD mutations.docx
Published 2025“…All patients achieved stable disease; however, a significant reduction in bone marrow blast percentage after one to two cycles of treatment was observed in two patients, which correlated with a decrease in FLT3-ITD allelic ratio and variant allele frequency of co-occurring mutations (e.g., NPM1 and DNMT3A). …”
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802
Betulinic acid protects SH-SY5Y cells exposed to lipopolysaccharide and ferrous sulfate through p38MAPK/NF-κB/GPX4/Nrf2/keap-1/HO-1 signaling axis
Published 2025“…Exposure to LPS and FeSO<sub>4</sub> increased the DMT1, Bax, caspase-3, and alpha-synuclein, and decreased the GPX4, FTH1, SLC7A11, Nrf2, Keap1, HO-1, PARK7, Bcl-2, NeuN, and TH levels, resulting in cell ferroptosis, apoptosis, and dopaminergic cell death. …”
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803
Table 1_Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction.xlsx
Published 2025“…Immune Microenvironment Profiling linked key genes to altered placental immune cell populations. qRT-PCR confirmed that GLUL and NCL expression decreased and DDX28 and RIOK1 expression increased in clinical placental samples of preeclampsia group.…”
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804
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805
Data Sheet 1_Screening of neurotransmitter receptor modulators reveals novel inhibitors of influenza virus replication.pdf
Published 2025“…In a mouse model of lethal influenza, isoxsuprine significantly decreased lung viral titers, mitigated pulmonary inflammation, and enhanced survival rates. …”
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806
Image 1_Immunosuppressants in dermatology on vaccine immunogenicity: a prospective cohort study of pemphigus patients in the pandemic.tif
Published 2024“…Intriguingly, we found that daily dosages of 100 mg or more of azathioprine were linked to significantly decreased anti-viral T-cell responses induced by the vaccination (mean of fold change [SD]; higher azathioprine dosage = 0.70 [0.61] folds vs. lower azathioprine dosage = 2.11 [1.03] folds; p = 0.044).…”
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807
Data Sheet 1_Andrographis paniculata restores gut health by suppressing inflammation and strengthening mucosal immunity.pdf
Published 2025“…</p>Results<p>ApEtOH significantly downregulated the chemokines RANTES, MCP-1, and ENA-78, reducing the pro-inflammatory cytokines TNF-α and IL-6 in vitro. …”
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808
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809
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810
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811
Presentation 1_Transcriptome signature in the blood of neuromyelitis optica spectrum disorder under steroid tapering.pptx
Published 2025“…All patients were positive for anti-AQP4 antibodies and had no history of biologic use.</p>Results<p>In one relapsed patient, gene groups with decreased expression at relapse were observed predominantly in monocytes, with upregulation in anti-inflammatory pathways such as IL-10, while the upregulated genes were related to interferon signaling. …”
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812
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813
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814
Table 1_Systematic pharmacology-based strategy to investigate the mechanism of beta-sitosterol for the treatment of rheumarthritis.docx
Published 2024“…The RT-PCR results showed that the expression of MMP9, HSP90AA1, SRC, EGFR, and ALB core genes in the control group was significantly upregulated, while the CASP3 gene was downregulated. …”
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815
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816
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817
Supplementary file 1_Mechanism of soil microbial community degradation under long-term tomato monoculture in greenhouse.docx
Published 2025“…<p>Tomato (Solanum lycopersicum L.), an economically significant crop, is frequently cultivated in greenhouses under continuous monoculture systems. …”
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818
Table 1_Patient and donor antibody profiles in early COVID-19 convalescent plasma therapy in the COnV-ert trial.pdf
Published 2025“…MB was associated with a significant decrease in cytophilic subclasses IgG1 and IgG3 to S and S2, and IgA to RBD, S and S2 in CCP units IgA to RBD, S and S2 in CCP units, without a reduction in neutralization titer and with a modest increase in IgG2 to RBD and S.…”
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819
Table 1_Urinary and oral microbiota in Polish women: a pilot case-control study of breast cancer.docx
Published 2025“…</p>Results<p>BC case urine microbiota contained an increased abundance of Corynebacterium (5.2-fold, but not significant) and Gammaproteobacteria including unknown genus and Pseudomonas (1.7- and 1.8-fold) and decreased abundance of Family XI (0.3-fold) and Bifidobacteriaceae (0.4-fold) compared to HCs. …”
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820