Image 1_Therapeutic potential and mechanistic insights of silibinin targeting cancer-associated fibroblasts in colorectal cancer.jpeg حسب Shenglan He (7641308)

Table 1_Therapeutic potential and mechanistic insights of silibinin targeting cancer-associated fibroblasts in colorectal cancer.xlsx حسب Shenglan He (7641308)

Data Sheet 1_Machine learning-driven prediction model for cuproptosis-related genes in spinal cord injury: construction and experimental validation.zip حسب Yimin Zhou (3857113)

"…Animal experiments confirmed a significant decrease in the behavioral scores of rats in the SCI group, pathological changes in tissue sections, and differential expression of candidate genes in the SCI rat model.…"

Antibodies used for flow cytometry. حسب Shanhe Liu (5251313)

"…Conversely, Caspase-3 (p = 0.0366), Caspase-9 (p = 0.0354), p21 (p = 0.0003), and p27 (p = 0.0164) protein levels were significantly higher in AN-LSCs than in LSCs. In LSCs, exposure to 75 µM CoCl₂ led to a reduction in <i>BCL2</i> mRNA (p = 0.0102) and protein levels (p = 0.0484), accompanied by an increase in <i>CDKN1B</i> mRNA level (p = 0.0265). …"

Primer pairs used for qPCR. حسب Shanhe Liu (5251313)

"…Conversely, Caspase-3 (p = 0.0366), Caspase-9 (p = 0.0354), p21 (p = 0.0003), and p27 (p = 0.0164) protein levels were significantly higher in AN-LSCs than in LSCs. In LSCs, exposure to 75 µM CoCl₂ led to a reduction in <i>BCL2</i> mRNA (p = 0.0102) and protein levels (p = 0.0484), accompanied by an increase in <i>CDKN1B</i> mRNA level (p = 0.0265). …"

Image 1_Augmentation of bone formation by sympathectomy in rats as evaluated by [99mTc]Tc-MDP.png حسب Zili Cai (15238729)

"…NE suppressed MC3T3-E1 proliferation (p < 0.0001), and co-culture with sympathetic neurons reduced mineralization and ALP activity (both p < 0.0001).…"

Image 1_COVID-19 mitigates the response to TKIs in patients with CML via the inhibition of T-cell immunity.pdf حسب Na He (295300)

"…</p>Results<p>Our results showed that the level of BCR-ABL P210 of CML patients was significantly elevated shortly after contracting COVID-19, and then recovered to pre-infection level within one month. …"

Data Sheet 1_Forecasting the production and export of shrimp in Bangladesh: a policy focused time series analysis.docx حسب Mobin Hossain Shohan (21495368)

"…</p>Results and discussion<p>The analysis reveals a steady rise in shrimp production, contrasting with a two-fold decline in export quantities from 2011 to 2023, largely due to quality non-compliance and contamination. The VAR(1) model predicts a slight decline in production by 2026–27, with exports potentially decreasing by a factor of 3.2 compared to 2010–11. …"

Data Sheet 1_Nonlinear responses of ecosystem carbon fluxes to precipitation change in a semiarid grassland.doc حسب Hua Chai (280388)

"…We found that both decreased and increased precipitation significantly altered the GEP (from –26% to 14%), but only decreased precipitation significantly reduced the ER and NEE (from 1% to 31%), relative to their values during natural precipitation. …"

Image 3_Inhibitior of Bcl6 by FX1 protects DSS induced colitis mice through anti-inflammatory effects.pdf حسب Ruixian Liu (5743817)

"…In cell experiments, we found that FX1 decreased secretion of pro-inflammatory factors by macrophages and increased expression of tight junction proteins in Caco2 cells after co-culture.…"

Image 5_Inhibitior of Bcl6 by FX1 protects DSS induced colitis mice through anti-inflammatory effects.pdf حسب Ruixian Liu (5743817)

"…In cell experiments, we found that FX1 decreased secretion of pro-inflammatory factors by macrophages and increased expression of tight junction proteins in Caco2 cells after co-culture.…"

Table 2_Inhibitior of Bcl6 by FX1 protects DSS induced colitis mice through anti-inflammatory effects.docx حسب Ruixian Liu (5743817)

"…In cell experiments, we found that FX1 decreased secretion of pro-inflammatory factors by macrophages and increased expression of tight junction proteins in Caco2 cells after co-culture.…"

Image 2_Inhibitior of Bcl6 by FX1 protects DSS induced colitis mice through anti-inflammatory effects.pdf حسب Ruixian Liu (5743817)

"…In cell experiments, we found that FX1 decreased secretion of pro-inflammatory factors by macrophages and increased expression of tight junction proteins in Caco2 cells after co-culture.…"

Image 4_Inhibitior of Bcl6 by FX1 protects DSS induced colitis mice through anti-inflammatory effects.pdf حسب Ruixian Liu (5743817)

"…In cell experiments, we found that FX1 decreased secretion of pro-inflammatory factors by macrophages and increased expression of tight junction proteins in Caco2 cells after co-culture.…"

Supplementary file 1_Tracing priming effects in palsa peat carbon dynamics using a stable isotope-assisted metabolomics approach.docx حسب Christian Ayala-Ortiz (15255371)

"…</p>Discussion<p>This suggests that while litter inputs temporarily increase CO₂ emissions, they don’t sustain long-term acceleration of stored carbon decomposition or substantially decrease peat’s carbon store capacity. …"

Data Sheet 1_Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction.docx حسب Jingjing Chen (293564)

"…Immune Microenvironment Profiling linked key genes to altered placental immune cell populations. qRT-PCR confirmed that GLUL and NCL expression decreased and DDX28 and RIOK1 expression increased in clinical placental samples of preeclampsia group.…"

Image 1_Identification of immune subtypes associated with CD8+ T cell-related genes providing new treatment strategies of esophageal carcinoma.pdf حسب Youyi Wu (20786402)

"…Compared with that in normal esophageal epithelial (HEEC cells), CHMP7 in the 6-gene prognostic risk model was upregulated in KYSE150 and TE-1 cells. Si-CHMP7 transfection led to a decrease in tumor cell migration, invasion, and proliferation, accompanied by an accelerated apoptotic process.…"

Data Sheet 1_Thermophilic microbial agents promote the fermentation progression of spent mushroom compost and pig manure.docx حسب Hongbo Du (1270113)

"…Notably, the co-addition of thermophilic microbial agents and SMC reduced persistent ARGs by lg0.45–3.73, significantly decreased the abundances of HPB such as Bacteroides and Treponema, and reduced the enrichment of related metabolic pathways, greatly improving compost quality. …"

Image 1_Ruminococcus bromii-generated acetate alleviated Clonorchis sinensis-induced liver fibrosis in mice.jpeg حسب Chun Li (57810)

"…Additionally, R. bromii conditioned medium (R.b CM) or its metabolites were co-cultured with two hepatic stellate cell lines (LX2 and JS1) in vitro to assess their anti-fibrotic effects. …"

DataSheet1_Synergistic effects of SAP and PGPR on physiological characteristics of leaves and soil enzyme activities in the rhizosphere of poplar seedlings under drought stress.pdf حسب Dawei Jing (18515707)

"…Compared with normal watering, the DR treatment significantly decreased the contents of dehydroascorbate (DHA; 19.08%), reduced glutathione (GSH; 14.18%), oxidized glutathione, soluble protein (26.84%), indoleacetic acid (IAA; 9.47%), gibberellin (GA) and zeatin (ZT), the IAA/abscisic acid (ABA), GA/ABA, ZT/ABA and (IAA+GA+ZT)/ABA (34.67%) ratios in leaves, and the urease and sucrase activities in the rhizosphere soil. …"