Image 9_Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.tiff by Ayaka Goto (20858771)

“…</p>Results<p>Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. …”

Image 8_Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.tiff by Ayaka Goto (20858771)

“…</p>Results<p>Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. …”

Image 2_Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.tiff by Ayaka Goto (20858771)

“…</p>Results<p>Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. …”

Video 1_Kininogen enhances seizure susceptibility in mice possibly through bradykinin-induced modulation of calcium transients in glutamatergic and GABAergic neurons.mp4 by Arijit Ghosh (1304952)

“…</p>Results<p>While scRNA-seq analyses found kininogen gene expressions in various cell types across the brain, immunofluorescence revealed its preferential localization in neurons but not in glia. Pilo-SE decreased intact kininogen levels in the hippocampus and increased cleaved to intact kininogen (cHK / iHK) ratio. …”

Image 5_Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.tiff by Ayaka Goto (20858771)

“…</p>Results<p>Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. …”

Comparisons of separability and variance of evidence distributions when noise and variability are manipulated independently for the 4-layer CNN across the three experiments. by Medha Shekhar (19502698)

“…On the other hand, separability of evidence distributions decreased significantly from the low to high variability condition and the variance of evidence distribution increased from the low to high variability conditions for all experiments.…”

Cardiovascular safety of Janus kinase inhibitors in inflammatory bowel disease: a systematic review and network meta-analysis by Huibin Yang (10486204)

“…</p> <p>Although a trend of increased cardiovascular risks was found considering dose, no significantly increased cardiovascular risk was associated with JAKinibs in IBD patients, and Deucravacitinib significantly decreased the risks of VTE and CVE.…”

Betulinic acid protects SH-SY5Y cells exposed to lipopolysaccharide and ferrous sulfate through p38MAPK/NF-κB/GPX4/Nrf2/keap-1/HO-1 signaling axis by Shivam Kumar Pandey (22295532)

“…Exposure to LPS and FeSO₄ increased the DMT1, Bax, caspase-3, and alpha-synuclein, and decreased the GPX4, FTH1, SLC7A11, Nrf2, Keap1, HO-1, PARK7, Bcl-2, NeuN, and TH levels, resulting in cell ferroptosis, apoptosis, and dopaminergic cell death. …”

Data Sheet 1_Dynamics of soil nutrients and biological activities along an infection chronosequence of pine wilt disease in subtropical Masson pine forests.docx by Xueyu Song (3600464)

“…The results revealed that soil non-capillary porosity, clay, microbial biomass carbon and microbial biomass nitrogen decreased significantly in 6 years forests. Available potassium consistently decreased with longer invasion periods, while soil polyphenol oxidase, leucine amino peptidase, and available phosphorous peaked in 6 years forests and then declined over time. …”

Exploratory investigation on conversion behaviors and coking tendency during coal-based asphaltene hydrogenation processes by Yuanlin Zhang (1694080)

“…And moreover, with hydrogen pressure increases from 2MPa to 4MPa, oil yield increases from 65.28% to 71.16% while coke yield decreases significantly from 8.85% to 2.90%, which indicates that relatively increase hydrogen pressure can effectively stabilize the free radicals to produce oil and restrict the generation of coke at 470°C. …”

<b>The Global Burden of </b><b><i>Klebsiella pneumoniae</i></b><b>-Associated Lower Respiratory Infection in 204 Countries and Territories, 1990–2021: Findings From the Global Burd... by Kaizhi XU (20895128)

“…The global burden of LRI due to <i>Klebsiella pneumoniae</i> significantly decreased over the study period, but lower SDI regions, children, and the elderly remain vulnerable and require targeted interventions to further reduce this burden.…”

Box plot of queens and males in the young colony (left) and old colony (right) A-B compares the queens and males distribution in the young and old colonies, respectively. by Moïse Pierre Exélis (21578515)

“…However, in the old colony, the median number of queens is approximately 2.5 times higher than in the young colony, while the number of males has decreased significantly.</p>…”

Image 4_Prediction of major adverse cardiovascular events following ST-segment elevation myocardial infarction using cardiac obesity marker—epicardial adipose tissue mass index: a... by Zeyan Liu (3748747)

“…Background<p>Although reperfusion therapy has led to improvements in the acute phase of ST-segment elevation myocardial infarction (STEMI), the incidence of major adverse cardiovascular events (MACE) following STEMI has not significantly decreased. The accumulation of epicardial adipose tissue (EAT) may be associated with poorer STEMI prognosis and could serve as a potential prognostic marker. …”

Data Sheet 2_A Delphi-based framework for optimizing nurse staffing in Chinese hospitals.docx by Waner Wang (17773704)

“…The primary objectives of this optimization process include reducing nurse workload, improving job satisfaction, and decreasing turnover rates, all of which facilitate improved patient outcomes.…”

Data Sheet 1_A Delphi-based framework for optimizing nurse staffing in Chinese hospitals.pdf by Waner Wang (17773704)

“…The primary objectives of this optimization process include reducing nurse workload, improving job satisfaction, and decreasing turnover rates, all of which facilitate improved patient outcomes.…”

Table1_Overexpression of endothelial S1pr2 promotes blood–brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models.DOCX... by Hongbo Cheng (2848235)

“…</p>Results<p>The expression of S1pr2 significantly increased following TBI in mice. Pharmacological inhibition of S1pr2 alleviated secondary injury with reduced lesion volume, ROS generation, cerebral oedema, neurological deficits, and neuronal apoptosis; BBB disruption was also mitigated, accompanied by reduced degradation of tight junction proteins and decreased induction of matrix metalloproteinases-9 (MMP-9) post-TBI. …”

Table 1_Impact of dual residual risk of cholesterol and inflammation on adult male sex hormones: a cross-sectional study from NHANES.docx by Yang Zhou (65942)

“…In the presence of both risk factors (BR), TT decreased most significantly (β = -79.37, 95% CI [-112.74, -46.00], p < 0.0001), as did FT in the same subgroup (β = -1.00, 95% CI [-1.61, -0.40], p = 0.0012). …”

Table1_Sucrose synthase gene family in common bean during pod filling subjected to moisture restriction.docx by Norma Cecilia Morales-Elias (20446292)

“….), leaf photosynthesis is significantly reduced under drought conditions. Previous studies have shown that some drought-tolerant cultivars use the pod walls to compensate the decreased photosynthesis rate in leaves by acting as temporary reservoirs of carbohydrates to support seed filling. …”

Image 2_Prediction of major adverse cardiovascular events following ST-segment elevation myocardial infarction using cardiac obesity marker—epicardial adipose tissue mass index: a... by Zeyan Liu (3748747)

“…Background<p>Although reperfusion therapy has led to improvements in the acute phase of ST-segment elevation myocardial infarction (STEMI), the incidence of major adverse cardiovascular events (MACE) following STEMI has not significantly decreased. The accumulation of epicardial adipose tissue (EAT) may be associated with poorer STEMI prognosis and could serve as a potential prognostic marker. …”

Image 5_Prediction of major adverse cardiovascular events following ST-segment elevation myocardial infarction using cardiac obesity marker—epicardial adipose tissue mass index: a... by Zeyan Liu (3748747)

“…Background<p>Although reperfusion therapy has led to improvements in the acute phase of ST-segment elevation myocardial infarction (STEMI), the incidence of major adverse cardiovascular events (MACE) following STEMI has not significantly decreased. The accumulation of epicardial adipose tissue (EAT) may be associated with poorer STEMI prognosis and could serve as a potential prognostic marker. …”