S1 Raw data - by Dao-Cheng Zhou (20314697)

“…All-cause and CVD mortality gradually decreased with increasing ideal LE8 metrics. LE8 was not significantly associated with cancer mortality. …”

Image1_Efficacy and Safety of a Polysaccharide-Based Natural Substance Complex in the Treatment of Obesity and Other Metabolic Syndrome Components: A Systematic Review.TIF by Giuseppina Guarino (6795282)

“…Decreased lipid levels were observed in adults following a normocaloric diet who received PGR for 30 days. …”

Data Sheet 1_Wedelia trilobata-derived biochar mitigates chromium toxicity and improves physiological performance in hydroponically grown Chinese cabbage.docx by Fengyue Qin (21748557)

“…Additionally, the malondialdehyde (MDA) content decreased by 29.66% in roots and 15.98% in shoots. …”

Table 8_Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5.xlsx by M. Elakkya (21760439)

“…Under salt and osmotic stress, A. chroococcum W5 metabolomic profiling revealed adaptive responses, including elevated levels of osmoprotectants (proline, glycerol) and oxidative stress markers such as 2-hydroxyglutarate, while putrescine and glycine decreased.…”

Data Sheet 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.xlsx by Demos Kynigopoulos (12420457)

“…Gliclazide reduced neuroinflammation and partially preserved glial and neuronal markers. Both treatments decreased amyloid burden and modulated adipokine levels, with Alirocumab elevating leptin and omentin in brain and serum. …”

Image 10_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg by Chen Wang (88408)

“…Functional studies demonstrated that RBM15 loss led to increased expression of fumarate hydratase (FH). This led to decreased levels of fumarate, a metabolite known to suppress anti-tumor immune responses. …”

Data of all figures by Bingqing Ye (5149703)

“…Our findings evidence that SPD significantly ameliorates SALI via the regulation of AMPK-mediated necroptosis. …”

Image 3_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg by Chen Wang (88408)

“…Functional studies demonstrated that RBM15 loss led to increased expression of fumarate hydratase (FH). This led to decreased levels of fumarate, a metabolite known to suppress anti-tumor immune responses. …”

Image 7_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.tif by Chen Wang (88408)

“…Functional studies demonstrated that RBM15 loss led to increased expression of fumarate hydratase (FH). This led to decreased levels of fumarate, a metabolite known to suppress anti-tumor immune responses. …”

Image 6_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg by Chen Wang (88408)

“…Functional studies demonstrated that RBM15 loss led to increased expression of fumarate hydratase (FH). This led to decreased levels of fumarate, a metabolite known to suppress anti-tumor immune responses. …”

Supplementary file 1_IGF-1 secreted by mesenchymal stem cells affects the function of lymphatic endothelial progenitor cells: a potential strategy for the treatment of lymphedema.d... by Zekuan Xue (21398444)

“…After isolation of MSCs and LEPCs from the bone marrow of C57BL/6 J mice, in vitro experiments verified that insulin-like growth factor 1 (IGF-1) secreted by MSCs activated the PI3K/Akt/mTOR pathway to promote the proliferation of LEPCs; IGF-1 decreased the rate of apoptosis and affected the cycle progression of LEPCs and the nucleotide metabolism levels. …”

Image 2_Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging.tif by Viana Q. Pham (22081163)

“…Significantly, the adaptive regulation of Ptn expression and the ability to modulate fenestrated capillaries and vascular permeability were abolished in both ME and AP of aged animals. …”

<b>Human Milk Oligosaccharides Mitigate Infant </b><b>Diarrhea</b><b> </b><b>and </b><b>Anxiety</b><b>-like </b><b>Behaviors</b><b> via Gut Microbiota Modulation in an EPEC O127 In... by wang wenxiu (21257327)

“…Notably, HMOs reshaped the gut microbiota by increasing the relative abundance of short-chain fatty acids (SCFAs)-producing bacteria (e.g., <i>Lacrimispora</i>), thereby elevating fecal SCFAs levels while decreasing <i>Escherichia</i> and other harmful taxa. …”

Table 2_Gandouling ameliorates Wilson’s disease-associated liver fibrosis in mice with associated faecal microbiome and metabolome remodeling.xlsx by Lulu Tang (2664904)

“…Furthermore, a medium dosage of GDL treatment significantly rebalance microbiota composition and function and modulated lipid and lipid-like molecule levels.…”

Image 8_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg by Chen Wang (88408)

“…Functional studies demonstrated that RBM15 loss led to increased expression of fumarate hydratase (FH). This led to decreased levels of fumarate, a metabolite known to suppress anti-tumor immune responses. …”

Image 15_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg by Chen Wang (88408)

“…Functional studies demonstrated that RBM15 loss led to increased expression of fumarate hydratase (FH). This led to decreased levels of fumarate, a metabolite known to suppress anti-tumor immune responses. …”

Image 4_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.tif by Chen Wang (88408)

“…Functional studies demonstrated that RBM15 loss led to increased expression of fumarate hydratase (FH). This led to decreased levels of fumarate, a metabolite known to suppress anti-tumor immune responses. …”

Image 11_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg by Chen Wang (88408)

“…Functional studies demonstrated that RBM15 loss led to increased expression of fumarate hydratase (FH). This led to decreased levels of fumarate, a metabolite known to suppress anti-tumor immune responses. …”

Image 1_REDD1 attenuates cholestatic liver fibrosis and suppresses PI3K/AKT/mTOR pathway.jpg by Xiaonan Li (340228)

“…However, REDD1 overexpression ameliorated BDL-induced liver injury, reduced serum ALT/AST levels, and decreased collagen deposition, as evidenced by histological and molecular analyses (α-SMA and collagen I), indicating that REDD1 exhibited compensatory elevation in liver fibrosis. …”

Alternative therapeutic strategy for existing aortic aneurysms using mesenchymal stem cell–derived exosomes by Motoshi Kozakai (22435636)

“…In the MSC-ex group, the expression of IL-1β, TNF-α and MCP-1 decreased, and expression of IGF-1 and TIMP-2 increased. …”