Molecular docking showed that ABT-199 can fit into active site of ALK^Mutant. حسب Richard Junior Zapata Dongo (17912565)

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The binding energy values of ATP, ALK inhibitors and ABT-199 to ALK were obtained from AlphaFold and modeled protein structures. حسب Richard Junior Zapata Dongo (17912565)

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Dual luciferase primer. حسب Dequan Wang (6007007)

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shCCND1 plasmid. حسب Dequan Wang (6007007)

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CCND1 promoted chemoresistance in CRC. حسب Dequan Wang (6007007)

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Amino acids interactions and binding energy describe that ABT-199 binds to ALK^Mutant. حسب Richard Junior Zapata Dongo (17912565)

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Western blot analysis of drug combinations. حسب Richard Junior Zapata Dongo (17912565)

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ALKL1196M –ABT199 interactions. حسب Richard Junior Zapata Dongo (17912565)

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Overexpression of miR-1247-3p promoted apoptosis and inhibited resistance in drug-resistant cells. حسب Dequan Wang (6007007)

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ALK^wt–ABT199 interactions. حسب Richard Junior Zapata Dongo (17912565)

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BCL2 protein keeps their expression in different conditions treatment nevertheless each EML4-ALK cell modells exhibit variable expression. حسب Richard Junior Zapata Dongo (17912565)

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ALK inhibitors (Positive control) and ABT199 (Proposed binding) in complex with the ALK active side. حسب Richard Junior Zapata Dongo (17912565)

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Effect of miR-1247-3p on survival in colorectal cancer patients. حسب Dequan Wang (6007007)

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BCL2 antiapoptotic protein exhibits heterogeneous expression in Ba/F3 EML4-ALK^mutants. حسب Richard Junior Zapata Dongo (17912565)

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Loewe synergy-antagonism score analysis shows additive and synergistic effects after ALKi and ABT-199 combination treatment. حسب Richard Junior Zapata Dongo (17912565)

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S1 Raw images - حسب Dequan Wang (6007007)

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Introduction to the dataset. حسب Dequan Wang (6007007)

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Downregulation of miR-1247-3p inhibited apoptosis and reduced chemosensitivity in cells. حسب Dequan Wang (6007007)

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Negative (Prednisone) and basal (ATP) control compounds binding to ALK protein. حسب Richard Junior Zapata Dongo (17912565)

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miR-1247-3p was downregulated in tissues of patients with CRC and was associated with prognosis and drug resistance. حسب Dequan Wang (6007007)

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