Data Sheet 2_Frailty and cardiovascular safety of JAK inhibitors versus TNF inhibitors in rheumatoid arthritis: a real-world comparative study of drug effects and patient profiles.... by Ettore Silvagni (9576002)

“…Each 0.1-point increment of the FI significantly increased the HR for new CVEs (HR: 1.80; 95% CI: 1.48–2.19), MACEs (HR: 1.66; 95% CI: 1.10–2.51), and TEs (HR: 1.69; 95% CI: 1.03–2.78). …”

Table 1_Assessment of platelet-to-white blood cell ratio on short-term mortality events in patients hospitalized with acute decompensated heart failure: evidence from a cohort stud... by Xin Huang (11077)

“…Further threshold analysis revealed a threshold point for PWR at 15.88, where a decrease in PWR below this threshold was significantly associated with increased risk of all-cause mortality (p for log-likelihood ratio test = 0.046). …”

Differential neural dynamics in the GNP model incorporating electrodiffusion and ion concentration changes. by Zichao Liu (4591993)

“…(a) Upper panel: Neural discharge events in response to glutamate stimuli () in the GNP (black) and fGNP (red) models. …”

Table 1_Efficacy and safety of combination of frankincense and botulinum toxin in the treatment of blepharospasm: a protocol for a single-centre, open-label, randomized, controlled... by Shiyuan Gong (22754579)

“…Symptom improvement is defined as a decrease of one point or more in the Jankovic Rating Scale severity score compared to baseline in patients with BSP. …”

Table 1_Functional connectivity in burnout syndrome: a resting-state EEG study.docx by Natalia Afek (20655875)

“…Studies on neural mechanisms indicate significant changes in brain activity and changed patterns of event-related potentials in burnout subjects. …”

Table 2_Functional connectivity in burnout syndrome: a resting-state EEG study.docx by Natalia Afek (20655875)

“…Studies on neural mechanisms indicate significant changes in brain activity and changed patterns of event-related potentials in burnout subjects. …”

Table 1_Efficacy of encapsulated fecal microbiota transplantation and FMT via rectal enema for irritable bowel syndrome: a double-blind, randomized, placebo-controlled trial (CAP-E... by Natsuda Aumpan (9449957)

“…Primary endpoint was clinical response defined by ≥50-point decrease in IBS-symptom severity score (IBS-SSS) at 4 weeks. …”

Impact of Oral Semaglutide on Kidney Outcomes in People with Type 2 Diabetes: Results from the SOUL Randomized Trial by Johannes F. E. Mann (22017555)

“…</p><p dir="ltr">RESEARCH DESIGN AND METHODS</p><p dir="ltr">SOUL (NCT03914326), a randomized, double-blind trial, compared oral semaglutide vs placebo in people with T2D, ASCVD, and/or CKD, showing a 14% reduction in risk of major adverse CV events. Prespecified kidney outcomes included a 5-point composite (≥50% decrease in estimated glomerular filtration rate [eGFR], persistent eGFR <15 mL/min/1.73 m2, initiation of chronic kidney replacement therapy, or death from kidney or CV causes); a 4-point composite (excluding CV death); and eGFR decline. …”

Data Sheet 1_Efficacy and safety of reduning injection for severe pneumonia: a systematic review and meta-analysis.docx by Yan Wang (15435)

“…The meta-analysis results showed that the combination of RDN injection and conventional treatment or antibiotic treatment for patients with SP was superior to traditional and antibiotic treatments alone in terms of clinical efficacy [risk ratio = 1.25%; 95% confidence interval (CI) (1.20, 1.30); p < 0.00001], fever reduction time [mean difference (MD) = −1.55 days; 95% CI (−1.91, −1.18); p < 0.00001], cough disappearance time [MD = −1.97 days; 95% CI (−2.63, −1.31); p < 0.00001], lung rales disappearance time [MD = −2.39 days; 95% CI (−3.09, −1.70); p < 0.00001], chest X-ray improvement time [MD = −2.73 days; 95% CI (−2.96, −2.49); p < 0.00001], and hospitalization time [MD = −3.11 days; 95% CI (−3.80, −2.41); p < 0.00001]. Moreover, no significant improvement was observed in the Acute Physiology and Chronic Health Evaluation II (APACHE II) scale compared to the control group [MD = −2.45 points; 95% CI (−6.07, 1.17); p = 0.19]. …”

Supplementary Material for: Effect of frail phenotype on cardiorenal risk and healthcare utilization in older patients with chronic kidney disease by Sun C.-Y. (10070377)

“…Over 3.47 years, 38.9% faced composite renal outcomes, 13.3% MACE, 15.3% mortality, and more than half utilized healthcare. Every one-point frailty elevated composite renal outcome risk by 28.0 % (HR: 1.28, 95% CI:1.03–1.59) and significantly increased secondary outcomes (hospitalization [HR: 1.24, 95% CI: 1.06–1.46], unexpected ER visit [HR: 1.20, [95% CI:1.03–1.39], and mortality [HR: 1.51, 95% CI: 1.06–2.16]) but not for MACE [HR: 1.43, 95% CI: 0.99–2.08]. …”

Consequences of SARS-CoV-2 infection on testis function. by Stefanos Giannakopoulos (15628394)

“…TGF-β levels in <b>(E)</b> serum and <b>(F)</b> testis homogenates were measured using ELISA and expressed as ng/mL at indicated time points post-infection. <b>(G)</b> Sperm count per epididymis was measured at indicated time points (n, 3–5 mice per group). …”

Effects of liposomal bupivacaine (LB) and provider experience with LB on service utilization, clinical outcomes, and Medicare expenditures among fee-for-service (FFS) beneficiaries by Sarmistha Pal (13348959)

“…For each 10-percentage point increase in provider LB use-rate, the likelihood of ED admission, STACH admission, mortality, and OUD decreased by 0.1, 0.15, 0.01 and 0.02 percentage points, respectively. …”

Preliminary efficacy of eye movement desensitization and reprocessing for children aged 1.5–8 years with PTSD: a multiple baseline experimental design (<i>N</i> = 19) by Carlijn de Roos (8061239)

“…There was no dropout (0%) and no adverse events were reported.</p> <p><b>Conclusions:</b> The findings provide preliminary evidence of the safety, feasibility, and efficacy of six sessions of EMDR therapy for reducing paediatric PTSD and comorbidity in young children aged 1.5–8 years and, at the same time, decreasing parenting stress. …”

Data Sheet 1_Real world evidence of dupilumab effectiveness in a Colombian cohort of patients diagnosed with severe asthma.docx by Abraham Alí-Munive (21347201)

“…Follow-up data were categorized at various time points (2–4, 5–7, 8–10, 11–13, 14–18, and 19–25 months). …”

AI-guided EMS for chronic musculoskeletal pain: subgroup-level outcomes from a digital health platform by Maja Green (8462307)

“…</p> <p>Across ~185,000 sessions, users reported significant pain reduction. Mean pain decreased by 2.4 points (<i>p</i> < 0.001), exceeding 30% improvement, with benefits sustained at 12 and 24 months. …”

Video 1_Safety and effectiveness of a new minimally invasive glaucoma surgery namely trabeculotome tunneling trabeculoplasty in primary open-angle glaucoma.mp4 by Suzhen Wang (163752)

“…Postoperative IOP significantly decreased at all follow-up points except at 1 week (p < 0.05). …”

Data Sheet 1_Real-world analysis of leuprorelin acetate microspheres-based neoadjuvant therapy for patients with high-risk prostate cancer.docx by Changde Fu (20899748)

“…Testosterone showed a decreased tendency after neoadjuvant therapy, but without statistical significance (P=0.185). …”

Data Sheet 1_Hypocomplementemia dynamics during tocilizumab therapy in systemic juvenile idiopathic arthritis: a retrospective longitudinal study.xlsx by Jiayun Ling (15249289)

“…The mixed linear model revealed significant reductions in C3 (β = -0.058, P < 0.001), C4 (β = -0.061, P = 0.022), and sJADAS10-ESR scores (β = -0.628, P < 0.001) across all time points compared to baseline. …”

Data Sheet 2_Effect of thyme-ivy syrup on antiviral immune response in patients with mild COVID-19: a prospective, open-label, randomized pilot study.docx by Stephanie Dauth (13274397)

“…Secondary objectives included assessments of other blood parameters and time points, symptoms, and quality of life. Adverse events were reported at each study visit.…”

Data Sheet 1_Effect of thyme-ivy syrup on antiviral immune response in patients with mild COVID-19: a prospective, open-label, randomized pilot study.docx by Stephanie Dauth (13274397)

“…Secondary objectives included assessments of other blood parameters and time points, symptoms, and quality of life. Adverse events were reported at each study visit.…”