PONE-Dataset. by Furkan Özdemir (21560297)

“…Peak heart rate (p = 0.006) and heart rate reserve improved significantly within AG (p = 0.004). Peak VO₂ (p < 0.001), MET (p < 0.001), oxygen pulse (p = 0.006), knee extensor (p < 0.001) and handgrip strength decreased significantly within CG (p = 0.009). …”

Demographic characteristics of groups. by Furkan Özdemir (21560297)

“…Peak heart rate (p = 0.006) and heart rate reserve improved significantly within AG (p = 0.004). Peak VO₂ (p < 0.001), MET (p < 0.001), oxygen pulse (p = 0.006), knee extensor (p < 0.001) and handgrip strength decreased significantly within CG (p = 0.009). …”

Image 1_TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury.pdf by Ting Zhou (38572)

“…To explore the molecular mechanisms of TSLP’s effect, analysis of transcriptome sequencing and single-cell transcriptome sequencing and subsequent experiments were performed.</p>Results<p>In LPS-induced acute lung injury models, pretreatment with TSLP significantly alleviated lung injury, suppressed inflammatory cytokines secretion, and reduced macrophages and neutrophils infiltration. …”

Image 1_Double-lumen tubes verus single-lumen tube in patients undergoing minimally invasive cardiac surgery: a randomised, controlled clinical trial.pdf by Zhenzhong Wang (407028)

“…</p>Conclusions<p>Two-lung ventilation with single-lumen tube is easy to perform, significantly increases oxygenation, and decreases the incidence of postoperative complications and airway injuries. …”

Table 1_Retinal vessel metric analysis of type 1 diabetes mellitus in OCT angiography.docx by Nianfeng Tang (21536069)

“…In addition, the VD of the inferior parafoveal vein (P = 0.022) and superior parafoveal artery (P = 0.03) were significantly decreased in the NPDR group. Comparing the VD among NDR subgroups and control group, the VD of the superficial inferior parafovea of T1DM patients of early stage (less than 5 years) was significantly lower than that of normal people (p < 0.05), while the VD of the inferior parafoveal artery increased (P = 0.012).…”

Data Sheet 1_N-acetylcysteine reduces prefrontal reactivity to cocaine cues in individuals with cocaine use disorder.pdf by Etna J. E. Engeli (20793524)

“…While N-acetylcysteine showed no impact on subjectively rated cocaine craving, neural cue reactivity in the superior frontal gyrus was significantly decreased under N-acetylcysteine compared to placebo.…”

Table 3_Retinal vessel metric analysis of type 1 diabetes mellitus in OCT angiography.docx by Nianfeng Tang (21536069)

“…In addition, the VD of the inferior parafoveal vein (P = 0.022) and superior parafoveal artery (P = 0.03) were significantly decreased in the NPDR group. Comparing the VD among NDR subgroups and control group, the VD of the superficial inferior parafovea of T1DM patients of early stage (less than 5 years) was significantly lower than that of normal people (p < 0.05), while the VD of the inferior parafoveal artery increased (P = 0.012).…”

Supplementary file 1_To assess the impact of individualized strategy and continuous glucose monitoring on glycemic control and mental health in pregnant women with diabetes.docx by Mengxue Liu (5953361)

“…Glycemic parameters and scale scores were collected before and after individualized strategy.</p>Results<p>FBG and 2hPBG significantly decreased post-intervention in both groups (P<0.001). …”

Table 1_Exhaled breath particles as a diagnostic tool for bronchiolitis obliterans syndrome in lung transplant recipients: a longitudinal study.docx by Runchuan Gu (10911582)

“…The particle distribution between the different BOS grades had a similar pattern; however, it significantly decreased PFR with severity in the BOS grade.…”

Table 4_Retinal vessel metric analysis of type 1 diabetes mellitus in OCT angiography.docx by Nianfeng Tang (21536069)

“…In addition, the VD of the inferior parafoveal vein (P = 0.022) and superior parafoveal artery (P = 0.03) were significantly decreased in the NPDR group. Comparing the VD among NDR subgroups and control group, the VD of the superficial inferior parafovea of T1DM patients of early stage (less than 5 years) was significantly lower than that of normal people (p < 0.05), while the VD of the inferior parafoveal artery increased (P = 0.012).…”

Table 1_Inflammatory markers CRP and WBC as predictors of liver function impairment in multiple injury trauma patients: a repeated measures analysis.docx by Gang Wang (36685)

“…Statistical analyses employed both crude and adjusted GEE models with gender subgroup analysis.</p>Results<p>Elevated CRP levels significantly correlated with increased AST (OR = 2.17, 95% CI: 1.14–4.12, p = 0.019) and ALT (OR = 2.37, 95% CI: 1.22–4.63, p = 0.011). …”

Table 2_Retinal vessel metric analysis of type 1 diabetes mellitus in OCT angiography.docx by Nianfeng Tang (21536069)

“…In addition, the VD of the inferior parafoveal vein (P = 0.022) and superior parafoveal artery (P = 0.03) were significantly decreased in the NPDR group. Comparing the VD among NDR subgroups and control group, the VD of the superficial inferior parafovea of T1DM patients of early stage (less than 5 years) was significantly lower than that of normal people (p < 0.05), while the VD of the inferior parafoveal artery increased (P = 0.012).…”

Table 1_Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.docx by Jikai He (11888466)

“…</p>Methods<p>(1) Fecal samples from CRC patients (n=26) and healthy controls (n=20) were collected for metagenomic sequencing and untargeted metabolomics analysis; (2) The ability of B.o to produce NMS from orange fiber was validated in vitro; (3) A CRC mouse model was established using azoxymethane (AOM)/dextran sulfate sodium (DSS) induction, followed by evaluation of body weight, rectal bleeding, colorectal length, tumor number, and intestinal barrier function; (4) Network pharmacology, molecular docking, and western blot analysis were combined to verify the mechanism of action; (5) 16S rRNA sequencing was performed to analyze gut microbiota changes.</p>Results<p>(1) CRC patients showed significantly increased metabolic pathways including glycolysis, methane metabolism, beneficial amino acid degradation, and linoleic acid degradation, along with significantly decreased B.o abundance and NMS levels, which were positively correlated; (2) NMS significantly inhibited CRC cell proliferation, migration, and invasion, while promoting apoptosis; (3) Combined treatment with B.o and orange fiber or NMS alone reduced tumorigenesis and improved intestinal barrier function; (4) Mechanistic studies revealed that these effects could be mediated through downregulation of 5-hydroxytryptamine receptor 1D (HTR1D) expression and inhibition of the cAMP/PKA/IκBα/NF-κB pathway; (5) The treatments optimized gut microbiota structure and metabolite composition.…”

DataSheet1_Global burden of chronic kidney disease in adolescents and young adults, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.docx by Ping Sun (59933)

“…However, the global age-specific death rate significantly decreased from 2.96 (2.76, 3.15) to 2.86 (2.61, 3.11), and the age-specific DALY rate remained stable. …”

Table 2_Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.xlsx by Jikai He (11888466)

“…</p>Methods<p>(1) Fecal samples from CRC patients (n=26) and healthy controls (n=20) were collected for metagenomic sequencing and untargeted metabolomics analysis; (2) The ability of B.o to produce NMS from orange fiber was validated in vitro; (3) A CRC mouse model was established using azoxymethane (AOM)/dextran sulfate sodium (DSS) induction, followed by evaluation of body weight, rectal bleeding, colorectal length, tumor number, and intestinal barrier function; (4) Network pharmacology, molecular docking, and western blot analysis were combined to verify the mechanism of action; (5) 16S rRNA sequencing was performed to analyze gut microbiota changes.</p>Results<p>(1) CRC patients showed significantly increased metabolic pathways including glycolysis, methane metabolism, beneficial amino acid degradation, and linoleic acid degradation, along with significantly decreased B.o abundance and NMS levels, which were positively correlated; (2) NMS significantly inhibited CRC cell proliferation, migration, and invasion, while promoting apoptosis; (3) Combined treatment with B.o and orange fiber or NMS alone reduced tumorigenesis and improved intestinal barrier function; (4) Mechanistic studies revealed that these effects could be mediated through downregulation of 5-hydroxytryptamine receptor 1D (HTR1D) expression and inhibition of the cAMP/PKA/IκBα/NF-κB pathway; (5) The treatments optimized gut microbiota structure and metabolite composition.…”

Exogenous jasmonic acid alleviates Cu-induced damages in guinea grass by enhancing photosynthesis, antioxidant enzyme activity and modifying associated metabolites by Jian Ren (175424)

“…Seedlings were treated with Cu (300 µM), JA (10 µM), and their combinations <i>via</i> Hoagland solution in controlled growth chambers for 30 days. The results indicated that Cu stress significantly reduced superoxide dismutase (−51.2%) and peroxidase (−38.0%), chlorophyll content, net photosynthetic rate (<i>Pn</i>), and led to decreases in leaf length, width, plant height, and biomass (−49.7%). …”

Table2_Genome-wide identification and characterization of circular RNAs for exogenous trehalose-mediated heat stress responses in tea plants (Camellia sinensis).xls by Shizhong Zheng (381048)

“…Moreover, exogenous trehalose significantly reduced H₂O₂ and O2⁻ contents in tea plants under heat stress, suggesting that trehalose could mitigate heat-induced damage resulting from ROS overproduction.…”

Image3_Genome-wide identification and characterization of circular RNAs for exogenous trehalose-mediated heat stress responses in tea plants (Camellia sinensis).tif by Shizhong Zheng (381048)

“…Moreover, exogenous trehalose significantly reduced H₂O₂ and O2⁻ contents in tea plants under heat stress, suggesting that trehalose could mitigate heat-induced damage resulting from ROS overproduction.…”

Table1_Genome-wide identification and characterization of circular RNAs for exogenous trehalose-mediated heat stress responses in tea plants (Camellia sinensis).xls by Shizhong Zheng (381048)

“…Moreover, exogenous trehalose significantly reduced H₂O₂ and O2⁻ contents in tea plants under heat stress, suggesting that trehalose could mitigate heat-induced damage resulting from ROS overproduction.…”

Table4_Genome-wide identification and characterization of circular RNAs for exogenous trehalose-mediated heat stress responses in tea plants (Camellia sinensis).xls by Shizhong Zheng (381048)

“…Moreover, exogenous trehalose significantly reduced H₂O₂ and O2⁻ contents in tea plants under heat stress, suggesting that trehalose could mitigate heat-induced damage resulting from ROS overproduction.…”