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significant risks » significant risk (Expand Search), significant role (Expand Search)
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21281
Oral Astragalus polysaccharide alleviates adenine-induced kidney injury by regulating gut microbiota–short-chain fatty acids–kidney G protein-coupled receptors axis
Published 2024“…<p>Chronic kidney disease (CKD) can cause gut microbiota dysbiosis and decreasing production of short-chain fatty acids (SCFAs), which aggravate the injury of kidney. …”
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21282
Image 2_Slavs in the closet: computational genomic analysis reveals cryptic slavic signatures in the Avar Khaganate and their contribution to medieval Croatian population formation...
Published 2025“…This approach revealed substantial Baltic genetic components in early Slavic populations (57% in Slovakia/Slovenia) decreasing to 39%–51% in medieval Croatian samples. …”
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21283
Reactive Organic Gases from Vehicle Evaporative Emissions: Rates, Compositions, and Temperature Effects
Published 2025“…The emission composition shifted significantly across high-, normal-, and low-emitting vehicles: traditional hydrocarbons decreased progressively, while carbonyls/ketones increased, attenuating hydroxyl radical reactivity (OHR) reduction. …”
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21284
Table 5_Epizootic shell disease induces systemic transcriptomic shifts in Homarus americanus, characterized by increased shell degradation and impaired energy metabolism across tis...
Published 2025“…The hepatopancreas showed decreased expression of hemocyanin genes, which play key roles in oxygen transport and immune defense in crustaceans. …”
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21285
Unraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of <i>Pseudomonas aeruginosa</i> in an organotypic 3D lung epithelial cell model
Published 2025“…Compared to the <i>lasB</i> mutant, the wild-type strain significantly decreased inflammation by degrading MCP-1, IL-1β, GM-CSF, and IL-8. …”
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21286
Image 1_StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.tiff
Published 2025“…In contrast, silencing StACS3 significantly reduces stress-induced ethylene accumulation and enhances drought resilience, including decreased cell death and increased antioxidant activity. …”
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21287
Data Sheet 1_Effects of aging and valence on emotional response inhibition: conclusions from a novel stop-signal task.pdf
Published 2025“…Aging is associated with decreasing cognitive control and inhibition alongside improvements in emotional control and regulation. …”
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21288
Description of study characteristics.
Published 2025“…Loss of PrEP retention rates were significantly (p < 0.05) lower in studies from Europe, Australia and multiple regions (vs. …”
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21289
Image 6_Protective effects of soybean peptides on H2O2-induced oxidative injury in IPEC-J2 cells.jpeg
Published 2024“…However, pretreatment with SBP followed by H<sub>2</sub>O<sub>2</sub> inducement significantly increased cell viability to 72.99%, decreased cell apoptosis, increased SOD, CAT and GSH-Px activity (p < 0.05), down-regulated Bax and Caspase-3 gene expressions (p < 0.05), and up-regulated the gene expressions of ZO-1, Claudin-1, Occludin, catalase, glutathione GPX1, SOD1, HO-1, NQO1 and Nrf2, compared with the single H<sub>2</sub>O<sub>2</sub>–induced cells. …”
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21290
Image 4_Protective effects of soybean peptides on H2O2-induced oxidative injury in IPEC-J2 cells.jpeg
Published 2024“…However, pretreatment with SBP followed by H<sub>2</sub>O<sub>2</sub> inducement significantly increased cell viability to 72.99%, decreased cell apoptosis, increased SOD, CAT and GSH-Px activity (p < 0.05), down-regulated Bax and Caspase-3 gene expressions (p < 0.05), and up-regulated the gene expressions of ZO-1, Claudin-1, Occludin, catalase, glutathione GPX1, SOD1, HO-1, NQO1 and Nrf2, compared with the single H<sub>2</sub>O<sub>2</sub>–induced cells. …”
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21291
Image 3_Protective effects of soybean peptides on H2O2-induced oxidative injury in IPEC-J2 cells.jpeg
Published 2024“…However, pretreatment with SBP followed by H<sub>2</sub>O<sub>2</sub> inducement significantly increased cell viability to 72.99%, decreased cell apoptosis, increased SOD, CAT and GSH-Px activity (p < 0.05), down-regulated Bax and Caspase-3 gene expressions (p < 0.05), and up-regulated the gene expressions of ZO-1, Claudin-1, Occludin, catalase, glutathione GPX1, SOD1, HO-1, NQO1 and Nrf2, compared with the single H<sub>2</sub>O<sub>2</sub>–induced cells. …”
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21292
Image 5_Protective effects of soybean peptides on H2O2-induced oxidative injury in IPEC-J2 cells.jpeg
Published 2024“…However, pretreatment with SBP followed by H<sub>2</sub>O<sub>2</sub> inducement significantly increased cell viability to 72.99%, decreased cell apoptosis, increased SOD, CAT and GSH-Px activity (p < 0.05), down-regulated Bax and Caspase-3 gene expressions (p < 0.05), and up-regulated the gene expressions of ZO-1, Claudin-1, Occludin, catalase, glutathione GPX1, SOD1, HO-1, NQO1 and Nrf2, compared with the single H<sub>2</sub>O<sub>2</sub>–induced cells. …”
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21293
Muscles influence motoneuron at NMJ during the critical period, but motoneuron do not affect GluR composition in muscles.
Published 2025“…<p><b>(A)</b> Heat stress experienced during the embryonic critical period (32°C vs. 25°C control) leads to decreased postsynaptic GluRIIA. Simultaneous genetic manipulation of aCC motoneuron during embryonic stages does not affect GluRIIA in muscles. …”
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21294
Image 2_Protective effects of soybean peptides on H2O2-induced oxidative injury in IPEC-J2 cells.jpeg
Published 2024“…However, pretreatment with SBP followed by H<sub>2</sub>O<sub>2</sub> inducement significantly increased cell viability to 72.99%, decreased cell apoptosis, increased SOD, CAT and GSH-Px activity (p < 0.05), down-regulated Bax and Caspase-3 gene expressions (p < 0.05), and up-regulated the gene expressions of ZO-1, Claudin-1, Occludin, catalase, glutathione GPX1, SOD1, HO-1, NQO1 and Nrf2, compared with the single H<sub>2</sub>O<sub>2</sub>–induced cells. …”
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21295
Table 1_Protective effects of soybean peptides on H2O2-induced oxidative injury in IPEC-J2 cells.docx
Published 2024“…However, pretreatment with SBP followed by H<sub>2</sub>O<sub>2</sub> inducement significantly increased cell viability to 72.99%, decreased cell apoptosis, increased SOD, CAT and GSH-Px activity (p < 0.05), down-regulated Bax and Caspase-3 gene expressions (p < 0.05), and up-regulated the gene expressions of ZO-1, Claudin-1, Occludin, catalase, glutathione GPX1, SOD1, HO-1, NQO1 and Nrf2, compared with the single H<sub>2</sub>O<sub>2</sub>–induced cells. …”
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21296
Image 1_Protective effects of soybean peptides on H2O2-induced oxidative injury in IPEC-J2 cells.jpeg
Published 2024“…However, pretreatment with SBP followed by H<sub>2</sub>O<sub>2</sub> inducement significantly increased cell viability to 72.99%, decreased cell apoptosis, increased SOD, CAT and GSH-Px activity (p < 0.05), down-regulated Bax and Caspase-3 gene expressions (p < 0.05), and up-regulated the gene expressions of ZO-1, Claudin-1, Occludin, catalase, glutathione GPX1, SOD1, HO-1, NQO1 and Nrf2, compared with the single H<sub>2</sub>O<sub>2</sub>–induced cells. …”
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21297
Da-Yuan-Yin decoction suppresses NETs formation, inhibits the IL-23/JAK2/STAT3 signalling pathway, and modulates metabolic profiles and gut microbiota composition in damp-heat synd...
Published 2025“…Complete blood count (CBC), blood biochemistry, short-chain fatty acids (SCFAs), gut microbiota composition in the colon, and metabolites in the cecum were analyzed.</p> <p>DYY significantly reduced symptom scores and decreased CRP level, while also regulating parameters in CBC and biochemical profiles. …”
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21298
Phage–antibiotic interactions are determined by the antibiotic, not the phage.
Published 2025“…Nitrofurantoin shows significantly more synergistic interactions than doxycycline (<i>p</i> = 0.008, Wilcoxon signed-rank test). …”
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21299
Key model formula.
Published 2024“…This study underscores the significance of the COVID-19 vaccine booster policy. …”
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21300
Autophagy induced by mechanical stress sensitizes cells to ferroptosis by NCOA4-FTH1 axis
Published 2025“…Additionally, low mechanics significantly diminishes NCOA4, pivotal in mediating FTH1 phase separation-induced ferritinophagy. …”