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significant risks » significant risk (Expand Search), significant results (Expand Search)
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19321
Table 1_WTAP modulates macrophage polarization in rheumatoid arthritis by targeting exosomal circ-CBLB via m6A modification.docx
Published 2025“…Functional experiments demonstrated that WTAP overexpression decreased exosomal circ-CBLB levels and promoted macrophage polarization toward the pro-inflammatory M1 phenotype, which was reversed by m<sup>6</sup>A modification site mutation.…”
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19322
DataSheet1_Lipocalin-2 drives neuropsychiatric and cutaneous disease in MRL/lpr mice.docx
Published 2024“…</p>Results<p>In this study, we found that LCN2 deficiency significantly attenuates neuropsychiatric and cutaneous disease in MRL/lpr lupus prone mice, likely by decreasing local infiltration of immune cells into the brain and skin and reducing astrocyte activation in the hippocampus. …”
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19323
Table 1_Behavioral alterations in antibiotic-treated mice associated with gut microbiota dysbiosis: insights from 16S rRNA and metabolomics.xlsx
Published 2025“…The KEGG enrichment analysis of serum and brain samples showed that amino acid metabolism pathways, such as tryptophan metabolism, threonine metabolism, serotonergic synapsis, methionine metabolism, and neuroactive ligand-receptor interaction, were significantly decreased in antibiotic-treated mice. Our study demonstrates that long-term antibiotic use induces gut dysbiosis and alters metabolic responses, leading to the dysregulation of brain signaling molecules and anxiety-like behavior. …”
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19324
Image 2_Behavioral alterations in antibiotic-treated mice associated with gut microbiota dysbiosis: insights from 16S rRNA and metabolomics.tif
Published 2025“…The KEGG enrichment analysis of serum and brain samples showed that amino acid metabolism pathways, such as tryptophan metabolism, threonine metabolism, serotonergic synapsis, methionine metabolism, and neuroactive ligand-receptor interaction, were significantly decreased in antibiotic-treated mice. Our study demonstrates that long-term antibiotic use induces gut dysbiosis and alters metabolic responses, leading to the dysregulation of brain signaling molecules and anxiety-like behavior. …”
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19325
Data Sheet 1_The impact of cell density variations on nanoparticle uptake across bioprinted A549 gradients.docx
Published 2025“…This inverse relationship correlated with greater average cell surface area in lower-density regions, while differences in the proliferation rates of the A549 cells at varying densities did not significantly impact uptake, did not significantly impact uptake.…”
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19326
Table 1_Association of inflammatory biomarkers with new functional morbidity at hospital discharge in children who survive severe sepsis.docx
Published 2025“…</p>Results<p>New functional morbidity occurred in 38 children (32%) and was associated with increased plasma levels of interleukin (IL)-6, IL-18, sIL-2Ra, MCP1, IL-8 (CXCL8), sIL-1RII, IL-10, MIP1a, and IL-2r and decreased RANTES (CCL5) (p < .001) at all three timepoints. …”
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19327
Trends and Disparities in Rates of Hypoglycemia Among Hospitalized Patients with Type II Diabetes
Published 2025“…After adjustment for other patient characteristics, the youngest and oldest patients, and those hospitalized in earlier years (vs. 2022) had significantly higher rates of hypoglycemia. Black (adjusted odds ratio -aOR, 1.42 95% CI 1.36-1.49) or Hispanic patients (aOR 1.26 95% CI 1.17-1.35) had a greater risk of hypoglycemia compared with non-Hispanic White patients and women had borderline less hypoglycemia than men (aOR 0.95, 95% CI 0.89-1.00)</p><p dir="ltr">Conclusion: Inpatient hypoglycemia in the VA Health System has been declining though there are race, age and gender differences that remain unexplained. …”
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19328
Table 1_Efficacy and safety of acupuncture for postoperative gastroparesis syndrome: a systematic review and meta-analysis.docx
Published 2025“…The meta-analysis showed a significantly higher overall response rate in the acupuncture group than the control group [RD = 0.16, 95% CI (0.11, 0.21), p < 0.001]. …”
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19329
Supplementary Material for: Endoscopic Anti-reflux Mucosal Interventions for Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis of Efficacy, Safety, and Compara...
Published 2025“…AET decreased at 3–6 months (P<0.001). Overall AEs occurred in 13% of cases (bleeding: 3%; stricture: 8%; dysphagia: 8%). …”
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19330
Table 2_Association of inflammatory biomarkers with new functional morbidity at hospital discharge in children who survive severe sepsis.docx
Published 2025“…</p>Results<p>New functional morbidity occurred in 38 children (32%) and was associated with increased plasma levels of interleukin (IL)-6, IL-18, sIL-2Ra, MCP1, IL-8 (CXCL8), sIL-1RII, IL-10, MIP1a, and IL-2r and decreased RANTES (CCL5) (p < .001) at all three timepoints. …”
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19331
Data Sheet 1_Psychological and cultural correlates of illness conception and menopausal symptoms: a cross-sectional and longitudinal comparative study of Mosuo, Yi, and Han women.p...
Published 2025“…Both the menopausal symptoms and the scores for concerns and fears about illness among Mosuo women significantly decreased in 2020 compared to 2012 (p = 0.040, p = 0.010).…”
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19332
Tanshinone I as a novel therapeutic agent targeting von Willebrand factor-binding protein to mitigate <i>Staphylococcus aureus</i> pathogenicity
Published 2024“…Notably, the absence of vWbp does not hinder <i>S. aureus</i> growth, indicating that vWbp is an attractive target for combating <i>S. aureus</i> infections while mitigating the risk of antibiotic resistance. Our findings revealed that tanshinone I significantly inhibited vWbp-induced coagulation without affecting the proliferation of <i>S. aureus</i>. …”
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19333
Table 1_Supplementation of Yupingfeng polysaccharides in low fishmeal diets enhances intestinal health through influencing the intestinal barrier, immunity, and microflora in Macro...
Published 2024“…</p>Results<p>The LF diet significantly reduced growth performance parameters compared to the control group. …”
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19334
Supplementary file 1_Association of antenatal dexamethasone administration timing with outcomes in preterm infants in a low- and middle-income country.docx
Published 2025“…No other secondary outcomes differed significantly.</p>Conclusion<p>Dexamethasone administration within 24 h before delivery did not reduce mortality but significantly decreased the risk of severe NEC. …”
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19335
Supplementary Material for: Long-term outcomes and clinical factors associated with conventional therapy failure in intestinal Behçet’s disease: A retrospective cohort study in Jap...
Published 2025“…Concomitant glucocorticoid use significantly decreased from 12.7±11.7 mg/day at baseline to 2.4±2.5 mg/day at 1 year (p<0.001). …”
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19336
Supplementary file 1_Association of prenatal trajectories of depressive and anxiety symptoms with neurodevelopment of children aged 0-24 months: A prospective study.docx
Published 2025“…Compared with children whose mothers had low level of depressive or anxiety symptoms throughout pregnancy, children whose mothers experienced consistently moderate or high level of these symptoms had a higher risk of neurodevelopmental delay, while children whose mothers experienced moderate level of depressive or anxiety symptoms that decreased to low levels after the first trimester did not show a different risk of neurodevelopmental delay.…”
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19337
Table 1_Global, regional, and national esophageal cancer deaths and DALYs attributable to diet low in vegetables and fruits, 1990–2019: analysis for the global burden of disease st...
Published 2025“…The disease burden attributable to insufficient fruit intake (51,210 deaths, 12,497,75 DALYs) was significantly higher than that from inadequate vegetable intake (17,176 deaths, 4,203,09 DALYs). …”
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19338
Table2_Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer.xlsx
Published 2024“…PTPRD-AS1 knockdown decreased the proliferation, cloning, and migration of CAOV3 cells.…”
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19339
Table1_Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer.docx
Published 2024“…PTPRD-AS1 knockdown decreased the proliferation, cloning, and migration of CAOV3 cells.…”
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19340
Image1_Efficacy and Safety of a Polysaccharide-Based Natural Substance Complex in the Treatment of Obesity and Other Metabolic Syndrome Components: A Systematic Review.TIF
Published 2024“…Policaptil Gel Retard<sup>®</sup> (PGR), an oral macromolecule complex based on polysaccharides, has been demonstrated to significantly reduce body weight, peak blood glucose (BG) levels, insulin levels, and lipid levels, providing an interesting non-pharmacological therapeutic option for MetS-associated metabolic abnormalities, especially in younger patients.…”