Cochrane Collaboration’s risk of bias tool. حسب Zhuoyang Xia (21354186)

"…The DerSimonian–Laird random-effects model and the Cochrane Collaboration’s risk of Bias Tool were used for analysis and risk of bias assessment.…"

Bias risk assessments for each RCT study. حسب Xin Liu (43569)

Bias risk assessments for each RCS study. حسب Xin Liu (43569)

Study selection criteria. حسب Filip Stanicic (17808254)

"…The NICE quality appraisal checklist was used to assess risk of bias in included studies. We provided qualitative synthesis of evidence presented in extraction tables.…"

PICOS criteria for the SLR. حسب Filip Stanicic (17808254)

"…The NICE quality appraisal checklist was used to assess risk of bias in included studies. We provided qualitative synthesis of evidence presented in extraction tables.…"

PRISMA flow chart. حسب Filip Stanicic (17808254)

"…The NICE quality appraisal checklist was used to assess risk of bias in included studies. We provided qualitative synthesis of evidence presented in extraction tables.…"

Grade system. حسب Zhuoyang Xia (21354186)

"…The DerSimonian–Laird random-effects model and the Cochrane Collaboration’s risk of Bias Tool were used for analysis and risk of bias assessment.…"

Literature search. حسب Zhuoyang Xia (21354186)

"…The DerSimonian–Laird random-effects model and the Cochrane Collaboration’s risk of Bias Tool were used for analysis and risk of bias assessment.…"

Study characteristics. حسب Zhuoyang Xia (21354186)

"…The DerSimonian–Laird random-effects model and the Cochrane Collaboration’s risk of Bias Tool were used for analysis and risk of bias assessment.…"

Flowchart of literature retrieval. حسب Zhuoyang Xia (21354186)

"…The DerSimonian–Laird random-effects model and the Cochrane Collaboration’s risk of Bias Tool were used for analysis and risk of bias assessment.…"

Data extraction. حسب Zhuoyang Xia (21354186)

"…The DerSimonian–Laird random-effects model and the Cochrane Collaboration’s risk of Bias Tool were used for analysis and risk of bias assessment.…"

Details of the GWAS data in this study. حسب Jing Wang (6206297)

"…</p><p>Results</p><p>This study shows that increases of anti-H. pylori IgG seropositivity was significantly associated with an increased risk of CHD (OR=1.003, 95% CI:1.0001.006, P = 0.048) and increases in peak insulin response (β = 0.214, 95% CI: 0.025–0.403, P = 0.026), decrease in total free cholesterol levels (β = ‒0.031, 95% CI: ‒0.061 to ‒0.000, P = 0.045), decreased waist circumference (β = ‒0.073, 95% CI: ‒0.138 to ‒0.008, P = 0.027) and waist-to-hip ratio (β = ‒0.069, 95% CI: ‒0.136 to ‒0.002, P = 0.044). …"

Table 1_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 3_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 4_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 8_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 2_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 6_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 5_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 7_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"