Probing the Histamine H₁ Receptor Binding Site to Explore Ligand Binding Kinetics by Sebastiaan Kuhne (1474948)

“…Analysis of structure-kinetic relationships (SKR) can contribute to an improved understanding of receptor–ligand interactions. Here, fragment <b>1</b> (4-(2-benzylphenoxy)-1-methylpiperidine) was used in different fragment growing approaches to mimic the putative binding mode of the long residence time (RT) ligands olopatadine, acrivastine, and levocetirizine at the histamine H₁ receptor (H₁R). …”

Probing the Histamine H₁ Receptor Binding Site to Explore Ligand Binding Kinetics by Sebastiaan Kuhne (1474948)

“…Analysis of structure-kinetic relationships (SKR) can contribute to an improved understanding of receptor–ligand interactions. Here, fragment <b>1</b> (4-(2-benzylphenoxy)-1-methylpiperidine) was used in different fragment growing approaches to mimic the putative binding mode of the long residence time (RT) ligands olopatadine, acrivastine, and levocetirizine at the histamine H₁ receptor (H₁R). …”

Macrophages play a role in esAEV-induced proliferation. by Safia A. Essien (20108379)

Mortality dataset used in analysis. by Samuel Sendagala (21417164)

“…<div><p>Background</p><p>Uganda reported a significant reduction in the mortality rate of children under 5 years of age, from 146/1,000 live births in 2000–42/1,000 live births in 2021. …”

Manifestations of Post-COVID-19 Conditions (PCC) three months post-acute illness, among those with PCC, by age group^a. by Chelsea S. Lutz (16001569)

Assessment of ascending aortic remodeling 2 weeks after transverse aortic constriction (TAC) in male mice. by Zhen Zhou (184390)

“…<b>(C)</b> Histology analysis shows significantly increased medial thickening and elastic breaks, and decreased medial cell density in the mutant aortas compare with WT TAC aortas, with no difference of adventitial collagen accumulation. …”

Assessment of left ventricular (LV) remodeling 2 weeks after transverse aortic constriction (TAC) in male mice. by Zhen Zhou (184390)

“…<p><b>(A)</b> Representative images of LV contraction measurement from short-axis parasternal view using M-mode. …”

Histopathological analysis of ascending aorta and heart tissue 2 weeks after transverse aortic constriction (TAC) in female mice. by Zhen Zhou (184390)

“…<b>(B)</b> Histology analysis shows significantly increased medial elastic breaks and decreased medial cell density in the mutant aortas compare to WT TAC aortas, with no difference of medial area or collagen accumulation in the aortic adventitia and left ventricular posterior wall. …”

Effect of 0.1mM salicylic acid (SA) or hydrogen peroxide (H₂O₂) and salt treatment (0 and 75 mM NaCl) on the superoxide dismutase activity (SOD) in shoots (A)... by Amal Bouallegue (21512298)

Echocardiography and central blood pressure measurements 2 weeks after transverse aortic constriction (TAC) in female mice. by Zhen Zhou (184390)

Reduced expression of thermogenic and lipogenic genes of <i>aP2-Drp1</i>^f/f neonatal mice. by Yuta Ibayashi (20404811)

A schematic overview of genetic regulatory mechanisms against effect of alkali-stress on hemp seedling leaves. by Zeyu Jiang (5094320)

Effect of preplant treatments (a) and post-plant treatments (b) on anthracnose fruit rot (AFR) fruit biomass during the 2022/23 and 2023/24 growing seasons. by Baker D. Aljawasim (22765921)

Association between AIP and depression in total people by Siyi Deng (12887198)

LDH expression is a surrogate for cell death. by Bryan S. Margulies (21492667)

(A) Changes of left ventricular ejection fraction over time in Roxadustat and ESAs groups. by Jie Liu (15128)

Projections of incidence for hematological malignancies in mainland China. by Yu Fu (16582)

Projections of mortality for hematological malignancies in mainland China. by Yu Fu (16582)

(a) 48 sandstone samples used in this experiment, (b) ZYB-II vacuum pressurized water saturation device, (c)static strain gauge, (d) diagram of experimental system, including uniax... by Wenyu Lv (20139458)

Age- and sex-specific distribution of prevalence, incidence, mortality, and DALY rates for leukemia in mainland China. by Yu Fu (16582)