The protective effects of neferine against paracetamol-induced liver injury are associated with the activation of SIRT1/Nrf2/HO-1 signaling pathway and inhibition of NF-kappa B/TNF... by Mohammed A. Altowijri (22461945)

“…NEF also decreased hepatic level of oxidative stress biomarker, MDA and increased the hepatic levels of antioxidants: GSH, GR, GST, TAC, and SOD, NEF also counteracted the activation of NF-κB and inhibited the upregulation of different inflammatory cytokines as TNF-α and interleukins- (IL-1β and IL-6). …”

Table 1_Inverse association between atherogenic index of plasma and testosterone in US adult males: A large cross-sectional study from the NAHNES 2011–2016.xlsx by Tanjian Li (20431610)

“…</p>Conclusion<p>Increased levels of AIP correlate with decreased TT levels and a higher prevalence of TD. …”

The in vitro and in vivo effect of a chemokine inhibitor CTCE-9908 in combination with Kynurenine metabolites on tumour adhesion by Danielle Tatchum (16946574)

“…Results showed a statistically significant decrease in the percentage cell number in L-kyn- and CTCE-9908-treated sEnd-2 cells when compared to the vehicle control, suggesting the inhibitory effect of the compounds on adhesion. …”

DataSheet1_Risk of bone fracture by using dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in patients wit... by Mohamed E. A. Mostafa (19834779)

“…The risk of fracture was identified with the follow-up duration for each class. We found a significant decrease in the fracture risk by about 87% associated with patients who used SGLT2 inhibitors in combination with other glucose-lowering medications, followed by SGLT2 inhibitors alone by about 67%, then GLP-1 receptor agonists by about 60%, and at last DPP-4 inhibitors by about 55%.…”

DataSheet2_Risk of bone fracture by using dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in patients wit... by Mohamed E. A. Mostafa (19834779)

“…The risk of fracture was identified with the follow-up duration for each class. We found a significant decrease in the fracture risk by about 87% associated with patients who used SGLT2 inhibitors in combination with other glucose-lowering medications, followed by SGLT2 inhibitors alone by about 67%, then GLP-1 receptor agonists by about 60%, and at last DPP-4 inhibitors by about 55%.…”

DataSheet3_Risk of bone fracture by using dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in patients wit... by Mohamed E. A. Mostafa (19834779)

“…The risk of fracture was identified with the follow-up duration for each class. We found a significant decrease in the fracture risk by about 87% associated with patients who used SGLT2 inhibitors in combination with other glucose-lowering medications, followed by SGLT2 inhibitors alone by about 67%, then GLP-1 receptor agonists by about 60%, and at last DPP-4 inhibitors by about 55%.…”

Table 1_The adjunctive role of metformin in patients with mild to moderate ulcerative colitis: a randomized controlled study.docx by Ammena Y. Binsaleh (16631313)

“…</p>Study outcomes<p>Decrease in DAI and change in the level of measured serum and fecal markers.…”

Table 1_Microbiological effect of topically applied Weissella cibaria on equine pastern dermatitis.docx by Eva Styková (20507045)

“…The application of the W. cibaria strain was associated with a significant decrease of the genera Staphylococcus, Moraxella, and Rothia in the proliferative group and with a decrease of Streptococcus and Clostridium in both exudative and proliferative groups. …”

Supplementary Material for: Analysis of retinal and choroidal microvasculature in systemic sclerosis using optical coherence tomography angiography: A systematic review and meta-an... by Lohrasbi F. (20017569)

“…Meta-analysis findings revealed a significant decrease in vessel densities in both the superficial and deep capillary plexuses (SCP and DCP) among SSc patients compared to controls. …”

Table_1_RETRACTED: High glucose induced HIF-1α/TREK1 expression and myometrium relaxation during pregnancy.docx by Tengteng Li (9104024)

“…The contractility of cultured HUSMCs was significantly decreased under high glucose levels, which was consistent with increased expression of HIF-1α and TREK1 proteins. …”

Data Sheet 1_Methylglyoxal induces oxidative stress and ferroptosis of renal tubular epithelial cells in acute and chronic kidney injury mice.docx by Yongzheng Zhang (1479694)

“…MG promotes advanced glycation end product (AGE) formation and directly impairs cell function. MG levels are significantly increased in various renal diseases. …”

Supplemental Materials by Ying Wang (15199117)

“…Compared to lean male mice, obese male mice had significantly increased accumulation of fluorescein-conjugated dextran in multiple organs, higher levels of soluble VE-cadherin, impaired systolic function with decreased ejection fraction post-AP and lipolysis. …”

Data Sheet 1_Qifuyin alleviates anxiety and depression in 3×Tg-AD mice by modulating neuroendocrine function.zip by Tianhao Yu (8120651)

“…In the QFY-treated group, plasma CORT levels were significantly decreased, whereas FSH and LH levels were significantly increased. …”

Supplementary Material for: A case report: Metastatic Gestational Trophoblastic Neoplasia leading to acute respiratory failure and death. About a particularly challenging managemen... by figshare admin karger (2628495)

“…In second-line, the patient was treated with carboplatin, with no significant response. In third-line, Pembrolizumab was used, and the patient experienced a significant decrease in HCG. …”

Table 1_Loneliness and mental burden among German medical students during the fading COVID-19 pandemic: a mixed-methods approach.docx by Marvik Leich (20930363)

“…Binary regression models indicated a shift in loneliness risk factors: in winter 2021/22, being single, higher self-perceived stress levels, and decreased study motivation were associated with increased loneliness. …”

Table 2_A comprehensive and systematic review on resveratrol supplementation as a promising candidate for the retinal disease: a focus on mechanisms of action from preclinical stud... by Xiao-Min Lv (21575681)

“…Moreover, a decrease in malondialdehyde (SMD = −9.29,95% Cl = [−12.84, −5.74], p < 0.00001), reactive oxygen species level (SMD = −4.29,95% Cl = [-6.25, −2.32], p < 0.0001), cyclooxygenase-2 (SMD = −2.66, 95% Cl = [−4.01, −1.30], p =0.0001), tumour necrosis factor-α(SMD = −3.96,95% Cl = [−6.27, −1.65], p = 0.0008) and interleukin-6 (SMD = −3.32,95% Cl = [−4.20, −2.44], p < 0.00001) was observed. …”

Table 1_A comprehensive and systematic review on resveratrol supplementation as a promising candidate for the retinal disease: a focus on mechanisms of action from preclinical stud... by Xiao-Min Lv (21575681)

“…Moreover, a decrease in malondialdehyde (SMD = −9.29,95% Cl = [−12.84, −5.74], p < 0.00001), reactive oxygen species level (SMD = −4.29,95% Cl = [-6.25, −2.32], p < 0.0001), cyclooxygenase-2 (SMD = −2.66, 95% Cl = [−4.01, −1.30], p =0.0001), tumour necrosis factor-α(SMD = −3.96,95% Cl = [−6.27, −1.65], p = 0.0008) and interleukin-6 (SMD = −3.32,95% Cl = [−4.20, −2.44], p < 0.00001) was observed. …”

Roxadustat has risks of reversible central hypothyroidism in patients undergoing hemodialysis: a single-center retrospective cohort study by Emiko Otsuka (7519313)

“…TSH levels were significantly decreased from a median of 2.46 (interquartile range:1.60–4.51) mU/L before roxadustat treatment to 1.36 (0.72–2.41) mU/L during treatment (<i>p</i> < 0.001), and improved to 2.56 (1.78–4.63) mU/L after halting roxadustat (<i>p</i> < 0.001). …”

Supplementary Material for: Collagen I Derived Extracellular Matrix Motifs Alter Fibroblast Regenerative Response by figshare admin karger (2628495)

“…Soluble free mECMs induced changes in fibroblast phenotype as indicated by a decrease in proliferation, decrease in nuclei area, and increase in percentage of elongated cells. …”

Data Sheet 1_Perturbations in gut microbiota composition in patients with autoimmune neurological diseases: a systematic review and meta-analysis.pdf by Xiaolin Deng (5214647)

“…Regarding α-diversity, except for Chao1, which showed a consistent small decrease (SMD = −0.26, 95% CI = −0.45 to −0.07, p < 0.01), other indices demonstrated no significant changes. …”