Summary of miRNAs sequencing data quality. by Zhaowen Tan (12283502)

“…After training, total RNA was extracted from the left ventricular myocardium of rats in the SHR-SED group and the BFRT group, miRNAs were sequenced, followed by GO enrichment and KEGG pathway analyses, and the differentially expressed miRNAs were subsequently validated via qRT‒PCR.</p><p>Results</p><p>1) Hemodynamic tests revealed that the blood pressure of SHRs in the BFRT decreased significantly and that the blood pressure level of SHRs in the BFRT decreased more significantly than that of the simple resistance training groups did (P < 0.05). 2) Cardiac function tests revealed that the EF, FS, and MV E/A of SHRs in the BFRT significantly increased, whereas the HR, IVSd, IVSs, LVIDd, LIVDs, LVPWd, LVPWs and LV mass significantly decreased (P < 0.05). 3) Transcriptome sequencing revealed 9 differentially expressed miRNAs in the BFRT group compared with the SHR-SED group (2 miRNAs were significantly upregulated, and 7 miRNAs were significantly downregulated), with P < 0.05 and |log2FoldChange| ≥ 1 used as the criteria for differential significance. …”

The miRNA target genes. by Zhaowen Tan (12283502)

“…After training, total RNA was extracted from the left ventricular myocardium of rats in the SHR-SED group and the BFRT group, miRNAs were sequenced, followed by GO enrichment and KEGG pathway analyses, and the differentially expressed miRNAs were subsequently validated via qRT‒PCR.</p><p>Results</p><p>1) Hemodynamic tests revealed that the blood pressure of SHRs in the BFRT decreased significantly and that the blood pressure level of SHRs in the BFRT decreased more significantly than that of the simple resistance training groups did (P < 0.05). 2) Cardiac function tests revealed that the EF, FS, and MV E/A of SHRs in the BFRT significantly increased, whereas the HR, IVSd, IVSs, LVIDd, LIVDs, LVPWd, LVPWs and LV mass significantly decreased (P < 0.05). 3) Transcriptome sequencing revealed 9 differentially expressed miRNAs in the BFRT group compared with the SHR-SED group (2 miRNAs were significantly upregulated, and 7 miRNAs were significantly downregulated), with P < 0.05 and |log2FoldChange| ≥ 1 used as the criteria for differential significance. …”

Differential miRNA target gene pathway enrichment bubble map. by Zhaowen Tan (12283502)

a. Positive ion mode significant difference metabolite expression difference factor analysis (A) mild PTOA group VS severe PTOA group (B) mild PTOA group VS normal group (C) Severe... by Peng-fei Han (694841)

a. Positive ion mode, significant difference, metabolite level clustering heat map (A), mild PTOA group VS severe PTOA group, (B) mild PTOA group VS normal group, (C) severe PTOA g... by Peng-fei Han (694841)

Relationship between cigarettes per day and hazard ratio (HR) for CVD and mortality outcomes: a cubic spline model evaluation. by Erfan Tasdighi (9144667)

Crude and age-specific incidence rates (A), all-cause mortality rates (B), and prevalence rates (C) of liver cancer per 100,000 over 2014–2023. by Ayana Ablayeva (22103708)

Crude and type-specific incidence rates (A), all-cause mortality rates (B), and prevalence rates (C) of liver cancer per 100,000 over 2014–2023. by Ayana Ablayeva (22103708)

Crude and residence-specific incidence rates (A), all-cause mortality rates (B), and prevalence rates (C) of liver cancer per 100,000 over 2014–2023. by Ayana Ablayeva (22103708)

PP2B, but not PP1/PP2A, is involved in the NMDA-induced dephosphorylation of pS295. by Takahiko Chimura (729098)

Boxplot of the acoustic parameters of <i>Scinax pachycrus</i> in response to wind farm noise. The graphs show that calling males found in the ponds of the most intense noise classe... by Rogério Ferreira de Oliveira (11133750)

Heatmap of selected compounds which showed significant changes in concentration in potato tissues in response to ‘<i>Candidatus</i> Liberibacter solanacearum’ (Lso) infection (padj... by Margaret A. Carpenter (6104180)

Age-adjusted annual percent changes (APC) in incidence (A), mortality (B), and prevalence (C) rates per 100,000 over 2014–2023 for both sexes and sex-specific. by Ayana Ablayeva (22103708)

Comparative death probabilities of tumor-bearing mice across weeks of assessment. by Robert Botelho (20308297)

High ambient temperatures reduce body fat and alter the expression of genes involved in lipid metabolism. by Tucker Hopkins (20790529)

Primer sequences for qPCR. by Tucker Hopkins (20790529)

“…Furthermore, when S2R + <i>Drosophila</i> cells are incubated at high temperatures, there is a marked decrease in Akt phosphorylation, directly supporting the notion that elevated temperatures can inhibit insulin signaling in a cell-autonomous manner, independent of Ilp levels. …”

Source data for graphs. by Tucker Hopkins (20790529)

“…Furthermore, when S2R + <i>Drosophila</i> cells are incubated at high temperatures, there is a marked decrease in Akt phosphorylation, directly supporting the notion that elevated temperatures can inhibit insulin signaling in a cell-autonomous manner, independent of Ilp levels. …”

The reagents used in this study. by Tucker Hopkins (20790529)

“…Furthermore, when S2R + <i>Drosophila</i> cells are incubated at high temperatures, there is a marked decrease in Akt phosphorylation, directly supporting the notion that elevated temperatures can inhibit insulin signaling in a cell-autonomous manner, independent of Ilp levels. …”

Study timeline and methodological overview. by Robert Botelho (20308297)

Longitudinal assessment of animal weights and tumor metrics. by Robert Botelho (20308297)