Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…Additionally, it inhibited osteoclastogenesis by suppressing the RANKL/OPG ratio, modulating Eph-Ephrin signaling, and attenuating IL-1β-induced ROS and NF-κB activation <i>in vitro</i>. In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. …”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…Additionally, it inhibited osteoclastogenesis by suppressing the RANKL/OPG ratio, modulating Eph-Ephrin signaling, and attenuating IL-1β-induced ROS and NF-κB activation <i>in vitro</i>. In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. …”

Details of significantly differentially abundant metabolites (<i>PPP1CC</i>-SSKO vs control). by Jiahong Sun (6497603)

Regions of significance for the simple block slopes on proportion of risky decisions as a function of past-month nonsuicidal self-injury (NSSI) and task. by Brooke H. Nancekivell (19949839)

Correlation between HRV and cognitive performance variables (n = 45). by Min Wang (21070)

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Effects of Tai Chi exercise on anxiety of college students. by Min Wang (21070)

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Flowchart of the study protocol. by Min Wang (21070)

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Effects of Tai Chi exercise on theta oscillatory power of college students. by Min Wang (21070)

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Subject characteristics (n = 45). by Min Wang (21070)

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Transcriptome and Metabolome Based Mechanisms Revealing the Accumulation and Transformation of Sugars and Fats in Pinus armandii Seed Kernels during the Harvesting Period by Nan Li (155066)

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Optimal proportion under comprehensive balance analysis (vertical "*" indicates the number of occurrences for a certain factor at a certain level, horizontal "*" denotes the degree... by Junxia Zhou (14381598)

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S1 Fig - by Frank Chacky (3446654)

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Tricuspid regurgitation pressure gradient of all 17 dogs. by Nattapon Riengvirodkij (11268720)

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Malaria infection prevalence across different age groups and survey years is presented. by Frank Chacky (3446654)

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CD74 down-regulation in DC induces pro-inflammatory pathways. by Bianca Pellegrino (20314999)

Kaplan-Meier Survival Curve of three 2-Categorical Variables: (a) Survival Curve by Preceding Vehicle Drop-off Status Groups; (b) Survival Curve by Drop-off Duration Groups; (c) Su... by Fangyi Yang (18867853)

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Data Sheet 1_Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management.pdf by Nourhen Agrebi (14151222)

“…Background<p>Hyper-IgM syndrome (HIGM) is a genetic immunodeficiency characterized by elevated to normal IgM levels and decreased IgG, IgA, and IgE. The overlapping clinical presentations of different gene mutations complicate diagnosis and management.…”

Variation of T₂ spectrum of 0.38 water–binder ratio of concrete during F–T process under standard curing conditions: (a) Air content = 1.5%; (b) Air content = 3.6%; (c)... by YongHe Liu (20477123)

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CD74 regulates tumor progression. by Bianca Pellegrino (20314999)

SI Figure 1- uncropped western blots by Renata Goncalves (15806162)

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