Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…Additionally, it inhibited osteoclastogenesis by suppressing the RANKL/OPG ratio, modulating Eph-Ephrin signaling, and attenuating IL-1β-induced ROS and NF-κB activation <i>in vitro</i>. In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. …”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…Additionally, it inhibited osteoclastogenesis by suppressing the RANKL/OPG ratio, modulating Eph-Ephrin signaling, and attenuating IL-1β-induced ROS and NF-κB activation <i>in vitro</i>. In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. …”

S1 Fig - by Frank Chacky (3446654)

Tricuspid regurgitation pressure gradient of all 17 dogs. by Nattapon Riengvirodkij (11268720)

Malaria infection prevalence across different age groups and survey years is presented. by Frank Chacky (3446654)

CD74 down-regulation in DC induces pro-inflammatory pathways. by Bianca Pellegrino (20314999)

Kaplan-Meier Survival Curve of three 2-Categorical Variables: (a) Survival Curve by Preceding Vehicle Drop-off Status Groups; (b) Survival Curve by Drop-off Duration Groups; (c) Su... by Fangyi Yang (18867853)

Data Sheet 1_Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management.pdf by Nourhen Agrebi (14151222)

“…Immunophenotyping and functional studies found greatly reduced class-switched memory B cells and somatic hypermutations but normal T cell responses and NFkB activation.…”

Variation of T₂ spectrum of 0.38 water–binder ratio of concrete during F–T process under standard curing conditions: (a) Air content = 1.5%; (b) Air content = 3.6%; (c)... by YongHe Liu (20477123)

CD74 regulates tumor progression. by Bianca Pellegrino (20314999)

JTBS and Tubule Diameters. by Halime Tozak Yıldız (21238185)

Immunohistochemical analysis of SF-1 and StAR expression in interstitial area of testes (Olympus BX51, Tokyo, Japan. X40: Scale bar; 100 µm). by Halime Tozak Yıldız (21238185)

Variation of T₂ spectrum of 0.38 water–binder ratio of concrete during F–T process under −3 °C curing conditions: (a) Air content = 1.5%; (b) Air content = 3.6%; (c) Air... by YongHe Liu (20477123)

Variation of T₂ spectrum of 0.38 water–binder ratio of concrete during F–T process under 5 °C curing conditions: (a) Air content = 1.5%; (b) Air content = 3.6%; (c) Air... by YongHe Liu (20477123)

Ecosystem multifunctionality across warming treatment and season. by Melissa S. Shinfuku (19942206)

Relative abundance of the phyla of dominant bacteria based on 16S rRNA gene amplicon sequencing. by Melissa S. Shinfuku (19942206)

Ecosystem multifunctionality bacterial diversity (Shannon H and Pielou J) relationship. by Melissa S. Shinfuku (19942206)

Neural tracking of speech across linguistic timescales in relation to cognitive decline and hearing ability. by Elena Bolt (20396190)

(A) Overall cardiovascular-kidney-metabolic syndrome-related Age-Adjusted Mortality Rates per 1,000,000 in Adults in the United States, 1999 to 2022, and (B) Sex-Stratified cardiov... by Aman Goyal (19231397)

MoCA scores distribution and audiometry results for participants. by Elena Bolt (20396190)