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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
level decrease » levels decreased (Expand Search), level increased (Expand Search), teer decrease (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
level decrease » levels decreased (Expand Search), level increased (Expand Search), teer decrease (Expand Search)
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Overexpression <i>TRIM37</i> promotes myelin repair and inhibits cell apoptosis by upregulating PEX5.
Published 2025“…<b>(c, d)</b> ROS fluorescence detection (n = 3) indicated a significant decrease in oxidative stress levels in the OE-TRIM37 group compared to the LPC group. …”
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Downregulation of TRIM37 expression exacerbates pathological damage in the MS model.
Published 2025“…(h) qRT-PCR (n = 6) and <b>(i, j)</b> Western blot (n = 3) both showed a significant decrease in the <i>TRIM37</i> mRNA and protein levels in the LPC-induced MS model compared to the control group. * <i><i>P</i></i> < 0.05, ** <i><i>P</i></i> < 0.01, *** <i><i>P</i></i> < 0.001, **** <i><i>P</i></i> < 0.0001, ns = not significant.…”
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Primer sequences and information.
Published 2025“…Through bioinformatics analysis, TRIM37 was found to be significantly downregulated in MS patients. <i><i>In vitro</i></i> experiments demonstrated that overexpression <i>TRIM37</i> could stabilize PEX5 protein via non-degradative monoubiquitination, thereby maintaining peroxisomal metabolic function, reducing oxidative stress levels, significantly decreasing apoptosis in both oligodendrocytes and neurons, and promoting the expression of myelin basic protein (MBP). …”
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Table 1_Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management.docx
Published 2025“…Background<p>Hyper-IgM syndrome (HIGM) is a genetic immunodeficiency characterized by elevated to normal IgM levels and decreased IgG, IgA, and IgE. The overlapping clinical presentations of different gene mutations complicate diagnosis and management.…”
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