Table 1_Dihydromyricetin attenuates age-related macular degeneration: pharmacological effects and exploration of putative targets.docx حسب Hongyu Zhou (352858)

"…Western blot analysis further confirmed DHM-mediated suppression of apoptosis through regulation of p53, Bax, cleaved caspase-3, and Bcl-2 expression. High-dose DHM significantly attenuated retinal thinning (10.7% reduction), decreased pigment loss, and ameliorated structural disorganization in the outer nuclear layer (ONL). …"

Image2_Predicting candidate miRNAs for targeting begomovirus to induce sequence-specific gene silencing in chilli plants.jpeg حسب Vineeta Pandey (10043698)

"…Chilli cultivars infected with begomovirus have suffered significant decreases in biomass output, negatively impacting their economic characteristics. …"

Image 4_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.tiff حسب Tien Le (634791)

"…Crim1 encodes a type I transmembrane protein that is expressed at the cell membrane of lens epithelial and fiber cells at the stage of lens pit formation. Decreased Crim1 expression in the mouse reduced the number of lens epithelial cells and caused defective adhesion between lens epithelial cells and between the epithelial and fiber cells.…"

Table_1_Antioxidants and the risk of sleep disorders: results from NHANES and two-sample Mendelian randomization study.docx حسب Junjie Jiang (7255706)

"…</p>Results<p>Analysis of data from the 2011–2018 NHANES survey revealed a significant negative association between CDAI and sleep disorders (OR = 0.854, 95% CI 0.821–0.888, P < 0.001). …"

Table 2_Apoptosis and autophagy promote Babesia microti infection in tick midguts: insights from transcriptomic and functional RNAi studies.docx حسب Songqin Chen (9625886)

"…Functional assays demonstrated that RNA interference (RNAi)-mediated knockdown of caspase-7, caspase-9, and ATG5 significantly reduced the burden of B. microti. Conversely, pharmacological induction of autophagy using rapamycin increased B. microti load, whereas inhibition with 3-methyladenine (3-MA) decreased B. microti load.…"

Table 2_Global, regional, and national burden of musculoskeletal disorders, 1990–2021: an analysis of the global burden of disease study 2021 and forecast to 2035.doc حسب Meizhi Liu (21898892)

"…Frontier analysis revealed significant gaps between current burdens and achievable benchmarks, particularly in high-SDI regions, while some low-SDI regions demonstrated effective management despite limited resources. …"

Image2_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula... حسب Huipeng Fang (12587509)

"…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …"

Data Sheet 1_Direct economic burden of acute coronary syndromes in the Portuguese National Health Service—facts and trends between 2002 and 2022.pdf حسب Francisco Madeira (20892980)

"…</p>Conclusion<p>ACS represent a significant direct cost and economic burden for the NHS.…"

Data Sheet 5_Global, regional, and national burden of musculoskeletal disorders, 1990–2021: an analysis of the global burden of disease study 2021 and forecast to 2035.pdf حسب Meizhi Liu (21898892)

"…Frontier analysis revealed significant gaps between current burdens and achievable benchmarks, particularly in high-SDI regions, while some low-SDI regions demonstrated effective management despite limited resources. …"

Data Sheet 1_MicroRNAs regulate alveolar macrophage homeostasis and its function in lung fibrosis.docx حسب Nirmal Parajuli (751983)

"…Our recent study found that the loss of miRNAs in embryonic progenitors significantly decreased the number of TR-AMs in late-stage embryos, indicating that miRNAs are necessary for TR-AM development. …"

The efficacy of dexamethasone compared to prednisone/prednisolone for the management of pediatric patients with acute exacerbation of asthma: a systematic review and meta-analysis حسب Haochang Wang (21616180)

"…Moreover, dexamethasone decreased the risk of vomiting (RR 0.39, 95% CI (0.25, 0.59), I² = 26.62%) compared to prednisone-prednisolone.…"

Data Sheet 1_Primary care and specialist physicians’ prescribing preferences for concurrent probiotic-antibiotic therapy: a multinational clinical practice survey across 13 countri... حسب Stephan R. Vavricka (8994197)

"…<p>Antibiotic-induced intestinal microbiota disruption represents a significant clinical concern, yet physician practices regarding concurrent probiotic supplementation remain poorly characterized across international healthcare systems. …"

Data Sheet 1_Cellular immune responses of bovine polymorphonuclear neutrophils to Calicophoron daubneyi.pdf حسب Liliana M. R. Silva (9291971)

"…Bovine neutrophil total adenosine triphosphate concentration significantly decreased after exposure to CdAg 100 µg/mL, in line to the observed with the positive control (phorbol myristate acetate/ionomycin). …"

Supplementary file 1_The association of dietary pattern with the risk of common chronic diseases in Shandong Province, China: a cross-sectional study.docx حسب Xi Wu (128938)

"…Background<p>Chronic diseases have emerged as a significant public health challenge, impacting the well-being of the Chinese populace, despite scant research exploring the influence of dietary factors on these conditions. …"

Image 9_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.tiff حسب Tien Le (634791)

"…Crim1 encodes a type I transmembrane protein that is expressed at the cell membrane of lens epithelial and fiber cells at the stage of lens pit formation. Decreased Crim1 expression in the mouse reduced the number of lens epithelial cells and caused defective adhesion between lens epithelial cells and between the epithelial and fiber cells.…"

Evaluation of disparities in zinc coverage. حسب Keith Beam (20700854)

"…Our findings demonstrate the long-term success of the SUZY project and provide insights into best practices for impactful zinc scale-up programs including significant pre-launch implementation research addressing key knowledge gaps and partnering with research organizations. …"

Image6_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula... حسب Huipeng Fang (12587509)

"…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …"

Video 2_How can the left atrial strain be correctly determined by cardiovascular magnetic resonance feature tracking?.mp4 حسب Rehsan Akkuzu (20963705)

"…</p>Conclusion<p>Optimized LA planning procedure for assessment of the longest LA dimensions results in significant alterations in CMR quantifications with increased chamber volumetrics and decreased strain and strain rates compared to standard procedure.…"

Data Sheet 1_A novel bivariate nomogram for predicting sequela vaginal lesions after surgery in patients with HPV-associated cervical cancer.docx حسب Yueheng Liu (9228588)

"…The annual incidence of vaginal lesions decreased gradually from 6.97% in the first year (Y1) to 2.96% at year 5 (Y5). …"

Image1_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula... حسب Huipeng Fang (12587509)

"…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …"