Reliable high-PAP-1-loaded polymeric micelles for cancer therapy: preparation, characterization, and evaluation of anti-tumor efficacy by Fang Ye (112854)

“…These self-assembled micelles exhibited high entrapment efficiency (91.35%) and drug loading level (8.30%). As pH decreased, the micelles exhibited a significant increase in particle size and zeta potential, accompanied by a surge in PAP-1 release. …”

Data source and description. by Yunxia Zhang (30848)

“…The results show that: (1) the level of non-grain of cultivated land in Lianyungang City increased gradually from 6.01% to 11.10% from 2002 to 2022, and grain cultivation was mainly shifted to greenhouse vegetables, construction and development and abandonment. (2) the level of non-grain of cultivated land showed a spatial pattern of high along the north-west-south-east and decreasing to the two sides, and the pattern showed a trend of gradual weakening, with Moran’s I decreased from 0.90 to 0.42. (3) The dominant factors of the spatial differentiation of non-grain of cultivated land in different periods are different, among which GDP, population density, NDVI, and precipitation are always the main influencing factors. …”

Analytical framework. by Yunxia Zhang (30848)

“…The results show that: (1) the level of non-grain of cultivated land in Lianyungang City increased gradually from 6.01% to 11.10% from 2002 to 2022, and grain cultivation was mainly shifted to greenhouse vegetables, construction and development and abandonment. (2) the level of non-grain of cultivated land showed a spatial pattern of high along the north-west-south-east and decreasing to the two sides, and the pattern showed a trend of gradual weakening, with Moran’s I decreased from 0.90 to 0.42. (3) The dominant factors of the spatial differentiation of non-grain of cultivated land in different periods are different, among which GDP, population density, NDVI, and precipitation are always the main influencing factors. …”

VB2 cell fate analysis of <i>hlh-17</i>, <i>hlh-31</i>, and <i>hlh-32</i> mutant animals. by G. Robert Aguilar (13889674)

“…(<b>B</b>) In <i>hlh-17/31/32</i>^null mutants, <i>flp-32(syb4374)</i> reporter allele expression in VB2 is decreased, reaching the same level of expression as that in VB1. …”

Image 1_TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury.pdf by Ting Zhou (38572)

“…In addition, TSLP treatment significantly inhibited M1 macrophage polarization and promoted M2 macrophage differentiation. …”

Data Sheet 1_N-acetylcysteine reduces prefrontal reactivity to cocaine cues in individuals with cocaine use disorder.pdf by Etna J. E. Engeli (20793524)

“…While N-acetylcysteine showed no impact on subjectively rated cocaine craving, neural cue reactivity in the superior frontal gyrus was significantly decreased under N-acetylcysteine compared to placebo.…”

Data Sheet 1_Artificial intelligence-assisted delineation for postoperative radiotherapy in patients with lung cancer: a prospective, multi-center, cohort study.docx by Ziming Han (19926057)

“…In addition to better contouring accuracy, the AI-assisted delineation significantly decreased the consuming time and improved the efficiency.…”

Table 1_Inflammatory markers CRP and WBC as predictors of liver function impairment in multiple injury trauma patients: a repeated measures analysis.docx by Gang Wang (36685)

“…</p>Results<p>Elevated CRP levels significantly correlated with increased AST (OR = 2.17, 95% CI: 1.14–4.12, p = 0.019) and ALT (OR = 2.37, 95% CI: 1.22–4.63, p = 0.011). …”

Table 1_Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.docx by Jikai He (11888466)

“…</p>Results<p>(1) CRC patients showed significantly increased metabolic pathways including glycolysis, methane metabolism, beneficial amino acid degradation, and linoleic acid degradation, along with significantly decreased B.o abundance and NMS levels, which were positively correlated; (2) NMS significantly inhibited CRC cell proliferation, migration, and invasion, while promoting apoptosis; (3) Combined treatment with B.o and orange fiber or NMS alone reduced tumorigenesis and improved intestinal barrier function; (4) Mechanistic studies revealed that these effects could be mediated through downregulation of 5-hydroxytryptamine receptor 1D (HTR1D) expression and inhibition of the cAMP/PKA/IκBα/NF-κB pathway; (5) The treatments optimized gut microbiota structure and metabolite composition.…”

Table 2_Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.xlsx by Jikai He (11888466)

“…</p>Results<p>(1) CRC patients showed significantly increased metabolic pathways including glycolysis, methane metabolism, beneficial amino acid degradation, and linoleic acid degradation, along with significantly decreased B.o abundance and NMS levels, which were positively correlated; (2) NMS significantly inhibited CRC cell proliferation, migration, and invasion, while promoting apoptosis; (3) Combined treatment with B.o and orange fiber or NMS alone reduced tumorigenesis and improved intestinal barrier function; (4) Mechanistic studies revealed that these effects could be mediated through downregulation of 5-hydroxytryptamine receptor 1D (HTR1D) expression and inhibition of the cAMP/PKA/IκBα/NF-κB pathway; (5) The treatments optimized gut microbiota structure and metabolite composition.…”

Exogenous jasmonic acid alleviates Cu-induced damages in guinea grass by enhancing photosynthesis, antioxidant enzyme activity and modifying associated metabolites by Jian Ren (175424)

“…The results indicated that Cu stress significantly reduced superoxide dismutase (−51.2%) and peroxidase (−38.0%), chlorophyll content, net photosynthetic rate (<i>Pn</i>), and led to decreases in leaf length, width, plant height, and biomass (−49.7%). …”

Table 1_Schistosomiasis in Ghana from baseline to now: the impact of fifteen years of interventions.docx by Joseph Opare (5437238)

“…Background<p>Schistosomiasis is a major public health problem in Ghana, significantly impacted by the construction of dams during the 1960s that resulted in the creation of Lake Volta. …”

Long-term changes in macronutrients, micronutrients, and potentially toxic elements under 33 years of continuous chemical fertilizer and organic matter application by Toan Nguyen-Sy (6333815)

“…However, micronutrient element levels of Fe, Mn, and Zn decreased, likely due to redox reactions and runoff; meanwhile, potentially toxic elements showed weaker association with organic matter addition and different accumulation patterns in the soil. …”

Data Sheet 6_StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.pdf by Sadia Hamera (22524803)

“…In contrast, silencing StACS3 significantly reduces stress-induced ethylene accumulation and enhances drought resilience, including decreased cell death and increased antioxidant activity. …”

Table 1_CD3zeta-mediated modulation of TCR signaling: a novel strategy for neuroprotection in retinal ganglion cell degeneration.docx by Kexin Xu (757891)

“…The neuroprotective effect of CD3ζ knockdown was accompanied by the restoration of MAPK signaling, specifically the phosphorylation of ERK and p38, and attenuation of NF-κB activation, indicated by decreased p65 phosphorylation. Furthermore, CD3ζ knockdown reduced the levels of proinflammatory mediators (IL-1β, TNF-α, and MMP-9) and increased that of the anti-inflammatory cytokine IL-10, creating a retinal microenvironment conducive to neuroprotection.…”

Table 1_Effects of photoperiod on phytochemical profiles of four Ocimum basilicum genotypes in a hydroponic climate chamber.docx by Luana Pulvirenti (2925741)

“…The Italian genotype under the 6:4 photoperiod exhibited the highest concentration of total polyphenols (7.96 mg/g d.w.), including chicoric (3.52 mg/g), rosmarinic (2.79 mg/g), and caffeic acids (0.42 mg/g). Anthocyanin levels in the Rosie genotype also decreased with longer light exposure, with pelargonidin/delphinidin-based pigments dropping from 0.84 mg/g under 6:4 to 0.24 mg/g under 18:6. …”

Table 2_Effects of photoperiod on phytochemical profiles of four Ocimum basilicum genotypes in a hydroponic climate chamber.docx by Luana Pulvirenti (2925741)

“…The Italian genotype under the 6:4 photoperiod exhibited the highest concentration of total polyphenols (7.96 mg/g d.w.), including chicoric (3.52 mg/g), rosmarinic (2.79 mg/g), and caffeic acids (0.42 mg/g). Anthocyanin levels in the Rosie genotype also decreased with longer light exposure, with pelargonidin/delphinidin-based pigments dropping from 0.84 mg/g under 6:4 to 0.24 mg/g under 18:6. …”

Table 1_Elevated miR-17-5p facilitates mycobacterial immune evasion by targeting MAP3K2 in macrophages.doc by Md Shoykot Jahan (22776341)

“…Increased miR-17-5p suppressed MAP3K2 expression and attenuated MAPK signaling, reducing phosphorylation of ERK, JNK, and p38. This resulted in decreased production of inflammatory mediators (TNF-α, IL-6, IL-1β), reduced iNOS and ROS levels, and impaired bacterial clearance.…”

Table1_Gut microbiota and metabolomics unveil the mechanisms of Lomatogonium rotatum in ameliorating visceral fat and serum lipids in high-fat diet-induced obese mice.XLSX by Xiaoping Ji (531042)

“…The effects of LR on gut microbiota and serum metabolites in obese mice were then investigated by 16S rRNA sequencing technology and untargeted metabolomics, and correlation analysis was performed. LR significantly reduced body weight, feed intake, Lee’s index, visceral fat accumulation, serum TG, TC, AST and ALT, and elevated serum HDL levels in obese mice. …”

Data Sheet 1_Interaction with IGF1 overrides ANXA2-mediated anti-inflammatory functions of IGFBP5 in vivo.pdf by Yan Fan (575147)

“…Monocytes of adjuvant-induced arthritis rats and RA patients expressed less IGFBP5 than normal controls, but its blood levels increased significantly. Adipocytes secreted large amounts of IGFBP5. …”