Table 1_The advanced lung cancer inflammation index as a predictor of kidney stone risk in men: a cross-sectional analysis.docx by Yan Zhou (6523)

“…Background<p>Kidney stone incidence and recurrence are increasing, which poses significant health problems. …”

Supplementary file 1_Integrating Drosophila and Vibrio fischeri models for toxicity evaluation: uncovering detoxification trends in psoralea Fructus-TCM formulations.docx by Cheng Zhang (70708)

“…Enzyme assays indicated a decreasing toxicity trend for ESP and SSP compared to PF, with significant changes observed in female flies. …”

DataSheet2_Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and co... by Jingshuang Song (11340138)

“…Background<p>The proteome is a crucial reservoir of targets for cancer treatment. …”

Data Sheet 1_An analysis of the global burden of childhood and adolescent asthma attributable to high BMI: 1990–2021.pdf by Xinhui Zhang (1624039)

“…Statistical analysis showed a significant correlation between SDI and asthma burden (P < 0.001), with the overall disease burden increasing as SDI rose. …”

Data Sheet 1_Microbiota profiling from biopsied tissues in complex infections: a diagnostic and prognostic analysis through metagenomic next-generation sequencing.docx by Tiange Song (13878401)

“…Early mNGS sampling within 7 days after admission was associated with a significantly decreased risk of all-cause mortality (HR 0.18, 95% CI 0.04–0.94; P=0.04), treatment failure (OR 0.17, 95% CI 0.05–0.66; P=0.01), and increased probability of clinical resolution (OR 3.03, 95% CI 1.24–7.40; P=0.01).…”

Data Sheet 1_Global burden of disease among adolescents and young adults with drug use disorders, 1990–2021: based on GBD 2021.doc by Ming Wang (172316)

“…Additionally, we assessed the trend of the estimated annual percentage change (EAPC).</p>Results<p>Globally, the ASIR of new DUD cases among adolescents and young adults exhibited a decreasing trend from 1990 to 2021, with an EAPC of −0.46 (95% confidence interval: −0.52, −0.39). …”

Data Sheet 1_Global burden and trend of stroke attributable to metabolic risks among young adults (20–39 years old) from 1990 to 2021.docx by Qingguo Liu (9620123)

“…However, ASDR increased in specific regions, notably Sub-Saharan Africa for ischemic stroke and the Caribbean and Oceania for intracerebral hemorrhage and subarachnoid hemorrhage.</p>Conclusions<p>Despite a decline in ASDR, the absolute burden of stroke attributable to metabolic risks among young adults has increased globally, with significant regional and national disparities. …”

Data Sheet 1_Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc−/GPX4 pathway.csv by Jiejie Hu (6190622)

“…Introduction<p>Cerebral ischemia–reperfusion (IR) causes severe secondary brain injury. …”

Figure 3 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRP... by Makito Mizunuma (18950775)

“…Percentage of fragmented mitochondria on the <i>y</i>-axis represents the comparison between control and Acetalax-treated groups. <b>A,</b> Significant change in mitochondrial fragmentation is indicated by the brackets. *, <i>P</i> < 0.01; **, <i>P</i> < 0.005; ***, <i>P</i> < 0.0001 (using the Mann–Whitney <i>U</i> test, calculated in Prism 9.0). …”

DataSheet1_Shenshuaikang enema restores the intestinal barrier and microbiota-gut-kidney axis balance to alleviate chronic kidney disease via NF-κB pathway.docx by Yan Ye (549400)

“…Finally, 16S rRNA amplicon sequencing was used to monitor changes in intestinal flora in CKD patients before and after SSKE treatment.</p>Results<p>We found that SSKE improves renal function, attenuates renal fibrosis, reduces inflammatory factor levels, and decreases damage to intestinal and renal structures in adenine-induced CKD rats. …”

Table 2_The global burden of pediatric infective endocarditis (5–14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.pdf by Ying Xiao (6517)

“…The ARIMA model projected a potential stabilization or slight rebound in the global pediatric IE burden by 2035, particularly among girls, although wide confidence intervals highlight the uncertainty of long-term forecasts.</p>Conclusions<p>While significant progress has been made in reducing the global burden of pediatric IE, major geographic and socio-demographic inequalities persist. …”

Table 1_Global burden and future trends of gastric cancer in women of reproductive age: estimates from the GBD 2021 Study, 1990–2050.xlsx by Nan Jiang (21252)

“…This study follows GATHER guidelines.</p>Results<p>From 1990 to 2021, the GC burden in women aged 15–49 declined globally: ASPR decreased from 10.42 to 5.41 per 100,000 (EAPC −2.11), ASIR from 4.61 to 2.13 (EAPC −2.56), ASMR from 2.02 to 0.89 (EAPC −3.02), and ASDR from 59.6 to 23.8 per 100,000 (EAPC −3.00). …”

Data Sheet 1_Targeting the leptin receptor promotes MDA-MB-231 cells’ metabolic reprogramming and malignancy: the role of extracellular vesicles derived from obese adipose tissue.d... by Carol Costa Encarnação (21412730)

“…</p>Results<p>Our findings revealed that OB EVs induced significant phosphorylation of STAT3, a key signaling molecule in cancer progression, and promoted increased cell migration, dependent on fatty acid oxidation (FAO). …”

Table 1_Obstetric and perinatal outcomes in pregnancies conceived with donor versus partner sperm: a systematic review and meta-analysis.docx by Junjie Liu (193511)

“…For other outcomes, including gestational diabetes mellitus, ectopic pregnancy, placental abruption, placenta previa, large and small for gestational age, preterm birth, high and low birth weight, perinatal death, stillbirth, neonatal death, and congenital anomalies, no significant disparities were observed.</p>Conclusions<p>Donor sperm offers improved pregnancy outcomes for severe male infertility or paternally inherited genetic disorders but is linked to elevated risks of preeclampsia and pregnancy-induced hypertension. …”

Data Sheet 1_Factors influencing, and associated with, physical activity patterns in dogs with osteoarthritis-associated pain.xlsx by Christina Stevens (9737867)

“…However, only age, hindlimb joint pain, and hindlimb muscle atrophy had statistically significant effects on physical activity.</p>Conclusions and clinical relevance<p>Several factors influence activity patterns in dogs with OA pain. …”

Image 3_Club cell-derived brain-derived neurotrophic factor regulates murine airway mechanics and mucin production in response to IL-13 in a sex-dependent manner.jpeg by Amy Fagan (17678004)

“…</p>…”

Table 2_Global burden and future trends of gastric cancer in women of reproductive age: estimates from the GBD 2021 Study, 1990–2050.xlsx by Nan Jiang (21252)

“…This study follows GATHER guidelines.</p>Results<p>From 1990 to 2021, the GC burden in women aged 15–49 declined globally: ASPR decreased from 10.42 to 5.41 per 100,000 (EAPC −2.11), ASIR from 4.61 to 2.13 (EAPC −2.56), ASMR from 2.02 to 0.89 (EAPC −3.02), and ASDR from 59.6 to 23.8 per 100,000 (EAPC −3.00). …”

Data Sheet 1_Increased circulating levels of SP-D and IL-10 are associated with the development of disease severity and pulmonary fibrosis in patients with COVID-19.pdf by Xin Pan (3712768)

“…Among the biomarkers indicative of macrophage polarization, compared to non-ARDS patients, a significant increase in IL-10, Inducible nitric oxide synthase (iNOS), and Arginase-1 (Arg-1) were observed in ARDS patients, while Tumor necrosis factor-α (TNF-α) was decreased. …”

Table 1_Trend analysis of pediatric urolithiasis prevalence from 1990 to 2021 in the BRICS.docx by Zhi-gang Zhang (328212)

“…Background<p>The increasing epidemiological trend of pediatric urolithiasis over the past three decades has brought it to the forefront of public health attention. …”

Association between the difference in estimated GFR based on cystatin C versus creatinine in coronary artery diseases by Zechen Liu (9200014)

“…Moreover, this relationship is independent of genetic susceptibility.</p> <p>eGFR_diff was associated with CAD risk, where a high eGFR_diff corresponded to a decreased likelihood of CAD onset no matter genetic susceptibility.…”