Image 2_Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients.tif حسب Chanchan Xiao (9522614)

"…However, significant knowledge gaps remain regarding the CD8 T-cell immune reactivity to the Omicron variant. …"

Data Sheet 1_Brain injury, endocrine disruption, and immune dysregulation in HIV-positive men who have sex with men with late HIV diagnosis.docx حسب Yihui He (2936874)

"…Background<p>In the realm of public health, late human immunodeficiency virus (HIV) diagnosis remains prevalent and is associated with neuropsychiatric adverse events. …"

Image 2_Analysis and contrast of psoriasis disease burden trends in China and globally from 1990 to 2021.tif حسب Keyi Yu (8958845)

"…Furthermore, age-period-cohort (APC) analyses assessed the effects of age, time, and birth cohort, while an extended autoregressive integrated moving average model (ARIMA model) was used to forecast the psoriasis burden in China from 2022 to 2036.</p>Results<p>Between 1990 and 2021, China experienced significant changes in its age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR), and age-standardized DALY Rate (ASDR). …"

Image_2_Study of epirubicin sustained–release chemoablation in tumor suppression and tumor microenvironment remodeling.jpeg حسب Liangliang Meng (9500122)

"…On day 4 after local injection of the EPI gel, the expression of PD-L1 in abscopal tumors was upregulated, while the expression of PD-L1 in bilateral tumors in mice was significantly reduced after anti-PD-L1 treatment. The proportion of CD3⁺CD8⁺PD-1⁺ cells in the tumor and circulating blood in the EPI-GEL/PD-L1 group was decreased compared with that in the EPI-GEL (single injection of epirubicin) group.…"

Image 2_Kaixin San Jiawei granule improves cognitive function and alleviates neuronal damage in Alzheimer’s disease via multi-component and multi-target mechanisms.tif حسب Wei Liu (20030)

"…Active components of KSG and their potential targets and pathways were identified using mass spectrometry and network pharmacology, while partial validation was performed using molecular docking and Western blotting.</p>Results<p>In vivo, KSG significantly alleviated scopolamine-induced cognitive deficits in mice. …"

Image 1_Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients.tif حسب Chanchan Xiao (9522614)

"…However, significant knowledge gaps remain regarding the CD8 T-cell immune reactivity to the Omicron variant. …"

Image_1_Study of epirubicin sustained–release chemoablation in tumor suppression and tumor microenvironment remodeling.jpeg حسب Liangliang Meng (9500122)

"…On day 4 after local injection of the EPI gel, the expression of PD-L1 in abscopal tumors was upregulated, while the expression of PD-L1 in bilateral tumors in mice was significantly reduced after anti-PD-L1 treatment. The proportion of CD3⁺CD8⁺PD-1⁺ cells in the tumor and circulating blood in the EPI-GEL/PD-L1 group was decreased compared with that in the EPI-GEL (single injection of epirubicin) group.…"

Data Sheet 1_Unveiling causal immune cell–gene associations in multiple myeloma: insights from systematic reviews and Mendelian randomization analyses.docx حسب Hui Zhang (7197)

"…Background<p>The efficacy of novel chimeric antigen receptor T-cell (CAR-T) therapy is inconsistent, likely due to an incomplete understanding of the tumor microenvironment (TME). …"

Table 1_Probabilistic human health risk assessment of commercially supplied jar water in Gopalganj municipal area, Bangladesh.docx حسب Partha Pratim Brahma (19696279)

"…<p>Every day, the amount of quality fresh water decreases notably due to contamination of drinking water. …"

<b>Mass, Residency Duration, and Previous Experience Shape Post-Escalation but Not Pre-Escalation Outcomes in Experimental Territorial Contests of Atlantic Mudskippers (</b><b><i>P... حسب Michael Smith (21714377)

"…</p>…"

Table 1_Reconstructing Holocene centennial cooling events: synthesized temperature changes, chronology, and forcing in the Northern Hemisphere.xlsx حسب Sergey A. Gorbarenko (13696381)

"…<p>Numerous studies, spanning experimental, instrumental, historical, and modeled approaches, have delved into understanding climate change across the Holocene era and millennial-scale occurrences. …"

Identification of novel pathogenic mutations in <i>ATP6V0A4</i> associated with distal renal tubular acidosis and analysis of wild-type expression in glomerular disease حسب Yaru Jiang (17458815)

"…We demonstrated that the c.197-1G > C mutation disrupted mRNA splicing, causing exon 5 skipping and introducing a premature termination codon, c.2293_c.2296del AGCG introduced a premature termination codon, while c.2219C > T impaired protein expression, intracellular pH regulation, and ATPase activity. Additionally, ATP6V0A4 expression decreases during diabetes progression, contributing to tubular dysfunction and the development of diabetic kidney disease (DKD). …"

Data Sheet 1_Reconstructing Holocene centennial cooling events: synthesized temperature changes, chronology, and forcing in the Northern Hemisphere.docx حسب Sergey A. Gorbarenko (13696381)

"…<p>Numerous studies, spanning experimental, instrumental, historical, and modeled approaches, have delved into understanding climate change across the Holocene era and millennial-scale occurrences. …"

Inference of cell-type proportions from bulk RNAseq and dynamics during myocardial infarction in α1A-AR-KO mice. حسب Brian Gural (21781982)

"…</p>…"

DataSheet1_Probiotics combined with prebiotics alleviated seasonal allergic rhinitis by altering the composition and metabolic function of intestinal microbiota: a prospective, ran... حسب Yangfan Hou (8043884)

"…From baseline to day 91, mean difference between groups (MDBG) in the reduction of TNSS was -1.1 (-2.2, -0.1) (P = 0.04); MDBG in the increment of TNF-α was 7.1 pg/ml (95% CI: 0.8, 13.4, P = 0.03); the INF-γ level was significantly increased (P = 0.01), whereas that of IL-17 (P = 0.005) was significantly decreased in the test group, whilst mean difference within groups was not statistically significant in the placebo group; MDBG in the increment of acetate was 12.4% (95% CI: 7.1%, 17.6%, P <0.001). …"

Data Sheet 1_Overexpression of KPC contributes to ceftazidime-avibactam heteroresistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae.docx حسب Yitan Li (1449217)

"…Moreover, increasing the avibactam concentration to 8 or 16 mg/L or combining CZA with 0.5 × MIC tigecycline significantly suppressed the formation of CZA heteroresistance (P<0.05). …"

Data Sheet 1_Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms.pdf حسب Monika Jürgenson (14030901)

"…Background<p>Obesity is an emerging health problem worldwide as it is associated with increased risk of cardiovascular, metabolic, mental disorders, and cancer. …"

Multicomponent physical exercise program among community-dwelling older adults who are users of home care services: a quasi-experimental pilot study حسب Aida Ruiz-Fernández (22822586)

"…Frailty decreased on both scales (OR = 0.142 and 0.125). No further significant effects were observed.…"

Causal associations between gut <i>Bifidobacteriaceae</i> and transplant failure: a Mendelian randomization study حسب Han Yan (126662)

"…Single nucleotide polymorphisms that were strongly associated with gut microbiota abundance were selected as instrumental variables.</p> <p><b>Results:</b> The abundance of <i>Bifidobacteriaceae</i> demonstrated a significant causal relationship with transplant failure (inverse variance weighted [IVW] <i>p</i> = 0.049, OR = 0.658, 95% CI: 0.433–0.998), but was not related to the risk of transplantation status (IVW <i>p</i> > 0.200). …"

Table 1_Glucose and lipid metabolism in non-diabetic, non-obese patients with obstructive sleep apnea: sex differences.docx حسب Yuhan Wang (595964)

"…The high-density lipoprotein cholesterol (HDL-C) level in OSA participants was significantly lower (0.99 vs. 1.12 mmol/L, p = 0.036), and the triglyceride-glucose (TyG) index was significantly higher (8.74 vs. 8.45, p = 0.016), while there was no significant difference in the levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and non-HDL-C. …"