Baseline characteristics for HSJ, control and Denmark (without HSJ) in the preintervention period, N = 289.045. by Eva Rydahl (6260771)

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Change in maternal characteristics during 2003–2017, HSJ and control. by Eva Rydahl (6260771)

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Cesarean section. by Eva Rydahl (6260771)

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Flow chart of study participants. by Eva Rydahl (6260771)

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Timeseries analyses HSJ trend before- and during intervention. by Eva Rydahl (6260771)

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Absolute numbers among CS groups. by Eva Rydahl (6260771)

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HSJ and controls stratified by timing for CS and parity. by Eva Rydahl (6260771)

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This diagram summarizes the main steps of our study, including data sourcing from the GBD 2021 database, stratified processing by disease stage, age, and sex, application of EAPC a... by Xinyue Qi (9637055)

Patient Example. by James M. Friedman (22522150)

Juvenile demyelination impairs the maturation of PV interneurons in the PFC. by Sara Hijazi (21656615)

“…Average action potential (AP) frequency in response to 0-650 pA current steps illustrating a significant decrease in PV interneuron firing frequency in cuprizone-treated mice. …”

PV interneurons from Shiverer mice show many similarities with the ones from mice that underwent juvenile demyelination. by Sara Hijazi (21656615)

“…Average action potential (AP) frequency in response to 0-650 pA current steps illustrating a significant decrease in PV interneuron firing frequency in Shiverer mice (<i>group x current two-way repeated measures: n = 25/25 cells from 9 mice per group: F(13,624) = 2.303, **p < 0.0056</i>). …”

Adult demyelination has no effect on PV interneuron’s firing rate or failures in autaptic responses. by Sara Hijazi (21656615)

Remyelination in adulthood leads to an incomplete restoration of PV interneuron properties. by Sara Hijazi (21656615)

“…Average action potential (AP) frequency in response to 0-650 pA current steps illustrating a significant decrease in PV interneuron firing frequency in remyelination (green) mice (<i>group x current two-way repeated measures: n = 25/19 cells from 8 mice per group: F(13,546) = 3.962, ***p < 0.001</i>). …”

Juvenile demyelination induces a loss of functional autapses. by Sara Hijazi (21656615)

“…Cuprizone-treated mice show a significant decrease in the percentage of cells showing an autaptic response (<i>Fisher’s exact test; *p = 0.0173</i>). …”

AUT00201 (1 µM) can rescue AP width in cuprizone mice. by Sara Hijazi (21656615)

“…In the responsive cells from cuprizone mice (red) a significant increase in PV interneuron firing frequency at lower current steps (gray) was observed (<i>group x current two-way repeated measures: n = 8 cells from 4 mice: p = 0.05287; AUT00201 effect: F(1,60) = 5.050, *p = 0.0457. …”

Autapses play a crucial role in PV interneuron’s sustained firing at high frequencies. by Sara Hijazi (21656615)

“…Average action potential (AP) frequency in response to 0−650 pA current steps illustrating a significant increase in PV interneuron firing frequency at low-current steps in control cells without autapses (gray) compared to control cells with autapses (black). …”

Comparison between juvenile and adult demyelination. by Sara Hijazi (21656615)

“…Juvenile demyelination leads to impairment in PV interneuron maturation whereas adult demyelination induces a decrease in the excitability of PV interneurons. Summary data showing the averaged (± s.e.m) of the following intrinsic properties: (A) Resting membrane potential (RMP) (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, ****p < 0.0001, post-hoc LSD test: *p < 0.05, **p < 0.01, ****p < 0.0001</i>), (B) Input resistance (IR) (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0024, post-hoc LSD test: *p < 0.05, **p < 0.01, ***p < 0.001</i>), (C) Sag (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0083, post-hoc LSD test: *p < 0.05, **p < 0.01</i>), (D) Rheobase (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, p = 0.1230, post-hoc LSD test: *p < 0.05</i>) and (E) Action potential (AP) threshold (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, *p = 0.0452, post-hoc LSD test: *p < 0.05</i>), (F) AP half-width (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0058, post-hoc LSD test: **p < 0.01</i>), (G) Average action potential (AP) frequency in response to 0–650 pA current steps illustrating no significant change in S1 PV interneuron firing frequency following juvenile demyelination (<i>group x current two-way repeated measures: n = 36,30,19,24 cells from 9/8/8/6 mice per group: F(39,1,291) = 2.487, ****p < 0.0001</i>) and (H) Maximum firing frequency per group (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, ****p < 0.0001, post-hoc LSD test: ***p < 0.001, ****p < 0.0001</i>). …”

The RehaGait® system. by Johanna Rydja (12300797)

“…Step height was normalized postoperatively; all other variables remained significantly worse than the HI. …”

Flow chart of included patients and dropouts. by Johanna Rydja (12300797)

“…Step height was normalized postoperatively; all other variables remained significantly worse than the HI. …”

Dataset of the analyzed data. by Johanna Rydja (12300797)

“…Step height was normalized postoperatively; all other variables remained significantly worse than the HI. …”