LncRNA MCM3AP-AS1 protects against cerebral ischemia-reperfusion injury via targeting miR-27b-3p by Rouli Dai (17063211)

“…<p>Cerebral ischemia-reperfusion (CI/R) injury is a significant hurdle in ischemic stroke treatment. Substantial evidence indicates that long non-coding RNAs (lncRNAs) are implicated in CI/R injury. …”

Data Sheet 1_Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study.docx by Heinz Wiendl (237353)

“…IgG and IgM levels remained above the lower limits of normal in most participants. sNfL levels decreased, remaining reduced by M24. Significant reductions in the annualized combined unique active lesion count occurred from M2 onwards. …”

Data Sheet 2_Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study.csv by Heinz Wiendl (237353)

“…IgG and IgM levels remained above the lower limits of normal in most participants. sNfL levels decreased, remaining reduced by M24. Significant reductions in the annualized combined unique active lesion count occurred from M2 onwards. …”

Cage Friction Measurements in High-Speed Bearings by Joseph Leo Misenar (22504786)

“…The cage friction exhibited a dichotomic behavior, increasing in the oil-dominant regime at lower speeds and decreasing significantly in the air-dominant regime at higher speeds. …”

Data_Sheet_1_Banxia-Yiyiren alleviates insomnia and anxiety by regulating the gut microbiota and metabolites of PCPA-induced insomnia model rats.zip by Liang Wang (23021)

“…Additionally, there was a significant Pearson correlation between the genus-level differences in the gut microbiota and the differentially abundant metabolites among the G1–G2, G3–G2, and G6–G2 groups.…”

Table 1_Long-term multicomponent exercise enhances functional mobility in early-stage Parkinson’s disease: a 48-month retrospective cohort study.docx by Marcos Moura (22671914)

“…Assessments at baseline and 48 months included the Timed Up and Go (TUG), Six-Minute Walk Test (6MWT), peak oxygen uptake (VO₂peak), and muscle mass. …”

Figure 3 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRP... by Makito Mizunuma (18950775)

“…Percentage of fragmented mitochondria on the <i>y</i>-axis represents the comparison between control and Acetalax-treated groups. <b>A,</b> Significant change in mitochondrial fragmentation is indicated by the brackets. *, <i>P</i> < 0.01; **, <i>P</i> < 0.005; ***, <i>P</i> < 0.0001 (using the Mann–Whitney <i>U</i> test, calculated in Prism 9.0). …”

Data Sheet 1_The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects.pdf by Sijie Zhang (7429373)

“…Objective<p>This study aims to investigate the associations between MTNR1B rs724030 A>G variant and prediabetes risk, along with their correlations with clinical features, including plasma glucose and serum insulin levels during oral glucose tolerance test (OGTT), islet function, insulin resistance, and plasma lipid levels. …”

Table 1_Reconstructing Holocene centennial cooling events: synthesized temperature changes, chronology, and forcing in the Northern Hemisphere.xlsx by Sergey A. Gorbarenko (13696381)

“…Based on the constructed stack, we identified and categorized 15 notable Holocene centennial cooling events (HCCEs) in the NH (period with temperature decreases). To test the chronological validity of the constructed HCCEs, we compared them with the most accurately dated and highly resolved climate records during the last 3 kyr, which have been extensively investigated by the scientific community. …”

Data Sheet 1_Artificial clicks (Porpoise ALert) affect acoustic monitoring of harbour porpoises and their echolocation behaviour.pdf by Joseph G. Schnitzler (12084395)

“…</p>Results<p>The trained algorithm showed remarkable efficiency in discriminating between artificial PAL signals and natural harbour porpoise clicks, demonstrating good sensitivity (99.74%) and accuracy (97.12%) in the test dataset.</p>Discussion<p>The consequences for compromised monitoring are significant, particularly in regions with low harbour porpoise densities, where artificial signals may influence the interpretation of diurnal and seasonal aspects of natural harbour porpoise behaviour, leading to misinterpretations. …”

Data Sheet 1_Reconstructing Holocene centennial cooling events: synthesized temperature changes, chronology, and forcing in the Northern Hemisphere.docx by Sergey A. Gorbarenko (13696381)

“…Based on the constructed stack, we identified and categorized 15 notable Holocene centennial cooling events (HCCEs) in the NH (period with temperature decreases). To test the chronological validity of the constructed HCCEs, we compared them with the most accurately dated and highly resolved climate records during the last 3 kyr, which have been extensively investigated by the scientific community. …”

Caffeine induces proteome-wide changes in a Rob-dependent manner. by Christoph Binsfeld (21763112)

“…The double-sided Fisher’s exact test p-value for enrichment of OMPs among significantly decreased proteins is shown. …”

Supplementary Material for: Exclusively macular phenotype of non-syndromic MFSD8-related disease: A Case Report by figshare admin karger (2628495)

“…Introduction: The purpose of this report is to highlight the clinical phenotype and imaging findings in a patient with an exclusively macular phenotype of non-syndromic MFSD8-related disease, and to provide clinical evidence for pathogenicity reclassification of a variant of uncertain significance (VUS) MFSD8 c.291G>C (p.Trp97Cys). Case Presentation: A 47-year-old male with progressive vision loss exhibited symptoms indicative of maculopathy. …”

Study group background characteristics. by Zicheng Hu (3825313)

“…One-way ANOVA with Tukey’s multiple comparison test found significant differences (P<0.05) only for <b>HAD</b> (CD4 >500: P = 0.0004; Elites: P = 0.0028; AsE: P = 0.0067; CD4 200–349: P = 0.0069; RxNFL-: P = 0.0116; CD4 50–199: P = 0.0202; CD4 350–499 P = 0.0228) and <b>NSE</b> (CD4 >500: P = 0.0023; Elites: P = 0.0075; AsE: P = 0.0173; CD4 200–349 P = 0.0211; HIV-1- P = 0.024; RxNFL- P = 0.0337; CD4 50–99 P = 0.0479). …”

Summertime bedroom overheating in un-airconditioned UK urban apartments: factors influencing subjective and objective sleep outcomes by Iuliana Hartescu (1249374)

“…</p><p dir="ltr">Results: Night-time (22.00-07.00) bedroom temperatures rose significantly during HN (range BL = 17.5-26.4°C; HN = 22.0-29.3°C, p<0.001) with thermal comfort (p<0.001), ‘restfulness’ (p<0.001) and TST (p<0.05) significantly decreasing, while heat-related sleep disturbance significantly increased (p<0.001). …”

Heart looping variations in <i>Notch3</i> and <i>Nodal</i> compound mutants. by Tobias Holm Bønnelykke (20968460)

“…L, Left; LV, left ventricle; n.s., non-significant; R, Right; RV, right ventricle. See also <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002598#pbio.3002598.s014" target="_blank">S1 Data</a> for the underlying data.…”

FLEXI interactions with RNA-binding proteins. by Jun Yao (9646)

“…RNA-binding sites: I, within introns corresponding to FLEXIs; SS-I and SS-E, bimodally enriched across the 5’- and 3’ splice sites in unspliced pre-mRNAs with the midpoints in the intron or flanking exon (SS-I and SS-E, respectively; Figs <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.g004" target="_blank">4A</a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.s011" target="_blank">S11</a>). mRNA levels, RBPs whose knockdown resulted in significant difference in mRNA levels (increased or decreased, DESeq2 |LFC|≥1, adjusted p≤0.05) from host gene of FLEXIs with a binding site for that RBP compared to those genes whose transcripts lacked a binding site for the same RBPs based on ENCODE RBP-knockdown datasets (p≤0.05 calculated by Fisher’s exact test; <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.s013" target="_blank">S13 Fig</a>). …”

Rht1 functions in cell cycle progression and modulates fluconazole susceptibility. by Ci Fu (148006)

“…Log rank (Mantel-Cox) test assessed significant difference between wild type and <i><i>rht1</i></i>Δ/Δ. …”

Objective Quality Assessment of the Capsulorhexis – A Novel Augmented Reality Tool for Trainees and Experts by Daniel Rudolf Muth (21400388)

“…The augmented reality group was statistically significantly better in terms of circularity than the Expert support (Mann–Whitney’s <i>U</i>-test: <i>p</i> = .00175) and the No support group (Mann–Whitney’s <i>U</i>-test: <i>p</i> = .00268). …”

Table 1_MFN2-a multifaceted guardian against Parkinson’s pathophysiology: mitochondria, ferroptosis, inflammation and oxidative stress.docx by Yan Cheng (149222)

“…</p>Results<p>In PD models, the expressions of DHODH, MFN1, MFN2, GPX4, and FSP1 were significantly down-regulated, and their motor coordination, self-cognitive behavior, and exploration ability were decreased. …”