Image2_Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin resistance in metabolic syndrome by regulating the LXRα/SREBP-1 signaling pathway.TIF by Sisi Lei (10999575)

“…Background<p>Metabolic syndrome (MS) is a significant risk factor for cardiovascular and cerebrovascular diseases, primarily driven by insulin resistance (IR). …”

Table2_Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin resistance in metabolic syndrome by regulating the LXRα/SREBP-1 signaling pathway.XLSX by Sisi Lei (10999575)

“…Background<p>Metabolic syndrome (MS) is a significant risk factor for cardiovascular and cerebrovascular diseases, primarily driven by insulin resistance (IR). …”

Supplementary file 1_Integrating Drosophila and Vibrio fischeri models for toxicity evaluation: uncovering detoxification trends in psoralea Fructus-TCM formulations.docx by Cheng Zhang (70708)

“…Enzyme assays indicated a decreasing toxicity trend for ESP and SSP compared to PF, with significant changes observed in female flies. …”

Image1_Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin resistance in metabolic syndrome by regulating the LXRα/SREBP-1 signaling pathway.TIF by Sisi Lei (10999575)

“…Background<p>Metabolic syndrome (MS) is a significant risk factor for cardiovascular and cerebrovascular diseases, primarily driven by insulin resistance (IR). …”

Data Sheet 1_Reconstructing Holocene centennial cooling events: synthesized temperature changes, chronology, and forcing in the Northern Hemisphere.docx by Sergey A. Gorbarenko (13696381)

“…Based on the constructed stack, we identified and categorized 15 notable Holocene centennial cooling events (HCCEs) in the NH (period with temperature decreases). To test the chronological validity of the constructed HCCEs, we compared them with the most accurately dated and highly resolved climate records during the last 3 kyr, which have been extensively investigated by the scientific community. …”

Table1_Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin resistance in metabolic syndrome by regulating the LXRα/SREBP-1 signaling pathway.XLSX by Sisi Lei (10999575)

“…Background<p>Metabolic syndrome (MS) is a significant risk factor for cardiovascular and cerebrovascular diseases, primarily driven by insulin resistance (IR). …”

Table 1_COVID-19 pandemic increased ESKAPEEc bloodstream infections and amplified carbapenem resistance in Chinese children: a multicenter surveillance study (2016–2023).xls by Xiaoqiang Li (612879)

“…Methicillin-susceptible Staphylococcus aureus (MSSA) strains had lower vancomycin MIC ≥2 μg/mL levels compared to methicillin-resistant Staphylococcus aureus (MRSA) strains. Significant temporal differences were observed in MRSA isolates with linezolid MIC ≥2 μg/mL but not in MSSA isolates. …”

Data Sheet 1_Microbiota profiling from biopsied tissues in complex infections: a diagnostic and prognostic analysis through metagenomic next-generation sequencing.docx by Tiange Song (13878401)

“…Early mNGS sampling within 7 days after admission was associated with a significantly decreased risk of all-cause mortality (HR 0.18, 95% CI 0.04–0.94; P=0.04), treatment failure (OR 0.17, 95% CI 0.05–0.66; P=0.01), and increased probability of clinical resolution (OR 3.03, 95% CI 1.24–7.40; P=0.01).…”

Image 1_Ketogenic diet–induced changes in methylation status and neuropeptide signaling: relationships between S-adenosylmethionine (AdoMet), orexin-A, and metabolic health.pdf by Laura Mosca (704904)

“…Circulating AdoMet (−75.7%) and Orexin-A (−7.2%) levels also decreased significantly. AdoMet levels positively correlated with body weight, BMI, visceral adipose tissue, total cholesterol, fasting glycemia, triglycerides, HbA1c, and notably Orexin-A (R² = 0.3848, p < 0.0001).…”

Performance following comparative feedback by K. Skylar Powell (15384878)

“…Consistently positive feedback did not show a significant relationship with performance. These results suggest that educators and trainers should carefully consider how they deliver mixed feedback, potentially spacing it out or providing context, and recognize the potential benefits of informational, consistently negative feedback.…”

Data Sheet 1_Association of oxidative balance score with all-cause and cardiovascular mortality among patients with cardio-renal-metabolic disease.docx by Yucui Lin (21598376)

“…Moreover, Higher OBS quartiles were linked to a decreased risk of cardiovascular mortality, while no significant reduction was observed in the lower quartiles [model 3: Q2, Q3, Q4: aHR (95CI%) = 0.96(0.77–1.19), 0.78 (0.63–0.97), 0.70 (0.53–0.93), respectively; P for trend = 0.003]. …”

Image 1_Population pharmacokinetics of polymyxin B in critically ill patients with carbapenem-resistant organisms infections: insights from steady-state trough and peak plasma conc... by Jun Yang (2084)

“…PTA decreased as CrCL increased, with slight variations observed across different PLT levels. …”

Internal states adjust the Brp compartmental heterogeneity through octopamine. by Hongyang Wu (8856740)

“…Mann–Whitney <i>U</i>-test. <b>(C)</b> Sleep deprivation for 12 h decreases Brp::rGFP heterogeneity level in a <i>T</i>β<i>h-</i>dependent manner. …”

Data Sheet 1_Association of estimated glucose disposal rate with atrial fibrillation, heart failure and cardiovascular mortality in patients with diabetes: a prospective cohort stu... by Zhen Tan (384977)

“…Kaplan-Meier curves and Log-rank tests assessed AF, HF, and cardiovascular mortality incidence. …”

Evolutionarily conserved and functionally important amino acids in Artemis. by Ziwen Huang (17562948)

“…<i>P</i> values were analyzed with Student <i>t</i> test. ns, not significant.</p>…”

A Proposal for Implementation of Multi-Factor Authentication (MFA) System for Enhanced Security By Stephen Mikah Makoshi by Stephen Mikah Makoshi (20998469)

“…</p><p dir="ltr">4. <b>Testing and Integration</b>: 2-4 weeks.</p><p dir="ltr">5. …”

Table 1_Genetic diversity and antibiotic resistance of Mycobacterium bovis in bovines in the Delta area of Egypt.docx by Mohamed Sabry A. Elsayed (22235200)

“…Introduction<p>Mycobacterium bovis (M. bovis) causes significant financial harm to the cattle industry through decreased productivity and trade limitations, while also posing a risk to human health through zoonotic transmission, which is primarily from unpasteurized milk or close animal contact.…”

Table 1_TCF3 downregulation alleviates renal fibrosis via PI3K/Akt/mTOR pathway inhibition and autophagy restoration in diabetic nephropathy.docx by Chen-xiao Liu (22750118)

“…Statistical analyses were performed using one-way ANOVA followed by Tukey’s post-hoc test, with p < 0.05 considered statistically significant.…”

Table 1_Study on Chaiyuwendan decoction’s inhibition of hippocampal neuron apoptosis to alleviating depression by activating the AKT/CREB pathway.docx by Shaoliang Zhang (7523498)

“…Chaiyuwendan decoction (CYWD) has significant clinical efficacy in treating depression, however, its specific mechanism is still unclear. …”

Data Sheet 1_The role of ATP6V0D2 in breast cancer: associations with prognosis, immune characteristics, and TNBC progression.docx by Jingyu Zhang (256203)

“…Objective<p>Researches have identified ATPase H+ transporting V0 subunit d2 (ATP6V0D2) as a significant factor in various cancers. However, its prognostic value in breast cancer (BRCA) and its biological role in BRCA cells remain unclear.…”