Development of Novel PRMT7 Inhibitors for the Treatment of Prostate Cancer حسب Jiaxing Li (113609)

"…<b>A33</b> significantly inhibited the proliferation, colony formation, migration, and invasion of PCa cells and induced substantial cell cycle arrest and apoptosis. …"

Development of Novel PRMT7 Inhibitors for the Treatment of Prostate Cancer حسب Jiaxing Li (113609)

"…<b>A33</b> significantly inhibited the proliferation, colony formation, migration, and invasion of PCa cells and induced substantial cell cycle arrest and apoptosis. …"

Molecular Logic Gate for Sensing pH/Peroxynitrite with Potential Applications in Cisplatin Treatment حسب Lifang Guo (1460884)

"…With this probe, the significant roles of pH and ONOO^– in cisplatin treatment are disclosed, in which the cell account shows a dramatic reduction accompanied by decreased pH and upregulated ONOO^– levels. …"

Optimized Gas–Liquid Transport via Local Flow Field Management for Efficient Overall Water Splitting حسب Yingjie Ji (4797516)

"…By incorporating a hydrophobic and gas-venting layer, our design significantly shortens the bubble transfer path and reduces the level of accumulation. …"

Optimized Gas–Liquid Transport via Local Flow Field Management for Efficient Overall Water Splitting حسب Yingjie Ji (4797516)

"…By incorporating a hydrophobic and gas-venting layer, our design significantly shortens the bubble transfer path and reduces the level of accumulation. …"

Optimized Gas–Liquid Transport via Local Flow Field Management for Efficient Overall Water Splitting حسب Yingjie Ji (4797516)

"…By incorporating a hydrophobic and gas-venting layer, our design significantly shortens the bubble transfer path and reduces the level of accumulation. …"

Source data for Fig 2. حسب Qi Xu (134661)

"…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …"

Source data for lung metabolomics. حسب Qi Xu (134661)

"…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …"

Source data for Fig 5. حسب Qi Xu (134661)

"…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …"

Source data for Fig 1. حسب Qi Xu (134661)

"…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …"

Flow cytometry gating strategy for MDSC. حسب Qi Xu (134661)

"…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …"

Source data for Fig 3. حسب Qi Xu (134661)

"…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …"

Source data for Fig 4. حسب Qi Xu (134661)

"…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …"

Cyclization Decoded: Engineering Amylomaltase for Efficient α‑Glucan Transformations حسب Han Liu (288039)

"…Amylomaltases (AMs) can modulate the biochemical properties of α-glucan through a distinctive cyclization feature to form α-1,4-glucoside-linked large-ring polysaccharides (cycloamyloses; CAs), endowing α-glucan with significant health benefits and medical value. While the industrial application of CAs continues to progress, the mechanistic intricacies of the cyclization processand its nuanced interplay with hydrolysisremain only partially understood. …"

Cataract induction does not affect hunting behaviour in optimal light conditions (left panels) but causes impairments in challenging light environments (right panels). حسب Amartya T. Mitra (14043115)

"…Similarly, under bright and UV light, we did not detect differences in hunting success (E,G; <i>n</i>_{<i>control</i>} = 12, <i>n</i>_{<i>lens3RNAi </i>}= 23, <i>p</i>_horizontal = 0.28, <i>p</i>_vertical = 0.23), but observed a weak (nonsignificant) decrease in the hunting success of treatment individuals under dim white light (F,H; <i>n</i>_{<i>control</i>} = 13, <i>n</i>_{<i>lens3RNAi </i>}= 22, <i>p</i>_horizontal = 0.22, <i>p</i>_vertical = 0.42).…"

Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis حسب Jihyeon Yoon (8705706)

"…Furthermore, <b>19c</b> did not significantly inhibit hERG and cytochrome P450 enzymes. …"

Improving Cu₂ZnSnS₄‑Based Photocathodes for Solar Water Splitting via SnO₂ Overlayers حسب Peng Guo (134478)

"…Cu₂ZnSnS₄ has the appropriate optical properties required for photocathodes in solar water splitting systems; however, its performance is limited by poor carrier separation efficiency and stability. Herein, we use SnO₂ to modify the CdS/Cu₂ZnSnS₄ photocathode by a straightforward spin-coating process, significantly improving the photoelectrode efficiency and stability. …"

Improving Cu₂ZnSnS₄‑Based Photocathodes for Solar Water Splitting via SnO₂ Overlayers حسب Peng Guo (134478)

"…Cu₂ZnSnS₄ has the appropriate optical properties required for photocathodes in solar water splitting systems; however, its performance is limited by poor carrier separation efficiency and stability. Herein, we use SnO₂ to modify the CdS/Cu₂ZnSnS₄ photocathode by a straightforward spin-coating process, significantly improving the photoelectrode efficiency and stability. …"

Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis حسب Jihyeon Yoon (8705706)

"…Furthermore, <b>19c</b> did not significantly inhibit hERG and cytochrome P450 enzymes. …"

Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope حسب Elena Kriukova (21524544)

"…In the normal tissue of L2-IL1B mice, we demonstrate a statistically significant increase (<i>p</i> < 0.001) in Raman band intensities associated with free amino acids and a decrease in bands associated with lipids (<i>p</i> < 0.005) and carotenoids (<i>p</i> < 0.001) compared to healthy controls. …"