Proteomic and phosphoproteomic time course over sexual differentiation. by Melvin Bérard (7907558)

“…(<b>D</b>) Fold enrichment for TORC, TORC1, TORC2, Orb6, and Cdc2 substrates among phosphosites that change (gray), decrease (blue) or increase (red) in abundance during starvation (top) and mating (bottom). …”

Data Sheet 2_Phase 2 trial (NCI-COTC030) of adjuvant inhaled recombinant human IL-15 combined with amputation and adjuvant chemotherapy in dogs with appendicular osteosarcoma.pdf by Robert B. Rebhun (8479020)

“…Although plasma concentrations of key cytokines varied markedly with no significant differences between disease-free and metastatic-failure patients, inflammatory cytokines such as IL-6 showed absolute increases post-amputation and post-chemotherapy, correlating with decreases in cytotoxicity. …”

Data Sheet 1_Phase 2 trial (NCI-COTC030) of adjuvant inhaled recombinant human IL-15 combined with amputation and adjuvant chemotherapy in dogs with appendicular osteosarcoma.pdf by Robert B. Rebhun (8479020)

“…Although plasma concentrations of key cytokines varied markedly with no significant differences between disease-free and metastatic-failure patients, inflammatory cytokines such as IL-6 showed absolute increases post-amputation and post-chemotherapy, correlating with decreases in cytotoxicity. …”

Data Sheet 1_Integrative transcriptome and WGCNA analysis reveal key genes mainly in response to Alternaria alternata in Populus simonii × P. nigra.docx by Siyuan Liu (696701)

“…<p>In order to explore the molecular mechanisms of Populus simonii × P. nigra response to stress and screen for genes conferring resistance to Alternaria alternata, we carried out measurements of physiological and biochemical indices and transcriptomic sequence analysis of leaves of Populus simonii × P. nigra inoculated with A. alternata. The results showed that the variation trends of multiple hormone contents and enzyme activities were broadly similar at different time points, with H₂O₂, SA, JA, PPO, SOD, PAL and POD showing a trend of increasing and then decrease after inoculation with the pathogen. …”

Table 1_Integrative transcriptome and WGCNA analysis reveal key genes mainly in response to Alternaria alternata in Populus simonii × P. nigra.xlsx by Siyuan Liu (696701)

“…<p>In order to explore the molecular mechanisms of Populus simonii × P. nigra response to stress and screen for genes conferring resistance to Alternaria alternata, we carried out measurements of physiological and biochemical indices and transcriptomic sequence analysis of leaves of Populus simonii × P. nigra inoculated with A. alternata. The results showed that the variation trends of multiple hormone contents and enzyme activities were broadly similar at different time points, with H₂O₂, SA, JA, PPO, SOD, PAL and POD showing a trend of increasing and then decrease after inoculation with the pathogen. …”

<b>IER3IP1 mutations cause neonatal diabetes due to impaired proinsulin trafficking</b> by Hossam Montaser (10017443)

“…While these mutant stem cell lines differentiated normally into definitive endoderm and pancreatic progenitors, we observed that IER3IP1-KO stem cell derived-islets (SC-islets) presented a significant decrease in beta cell numbers and elevated ER stress. …”

COMPOSITIONS AND METHODS FOR TREATMENT OF NEUROLOGICAL DISEASE by Janice Keramedjian (19726261)

“…In some preferred embodiments, these have been designed using dehydroascorbic acid, ascorbic acid and amino acids as carriers that result in a significant increase in brain MMF concentration and mitochondrial biogenesis activity. …”

Kinetics of differential gene expression after rapid degradation of endogenous OGT in MEFs. by Sara Formichetti (20536052)

“…Differentially expressed genes with p-value < 10⁻⁵ and absolute log₂FC > 0.3 (i.e. 1.2-fold increase or decrease in expression) are labeled in red and their number is indicated. …”

Data Sheet 1_Enhancing AAV-microdystrophin gene therapy after repeat dosing by blocking phagocytosis.docx by Rita Spathis (187690)

“…</p>Results<p>Viral load was significantly increased by 77-fold in white blood cells after two rAAV9-microdystrophin doses compared to mice receiving a single dose. …”

Fas2 interacting partner IgCAMs Fipi and Elff are required for imaginal disc development. by Luis Garcia-Alonso (152388)

“…While the fas2 RNAi produces a strong decrease in MAPK activation with respect to the control siblings (see also [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0309891#pone.0309891.ref008" target="_blank">8</a>]), the combined expression of fipi and elff RNAis produces a significant increase.…”

pH sensitive lipid polymeric hybrid nanoparticle (LPHNP) of paclitaxel and curcumin for targeted delivery in breast cancer by Hrishikesh Sarma (14827761)

“…MTT-assay studies revealed enhanced cytotoxicity of CUR and PTX as LPHNPs showing IC₅₀ value of free CUR & PTX 480.06 µg/mL decreasing to 282.97 µg/mL for CS-CUR-PTX-LPHNPs. <i>In vivo</i> pharmacokinetic evaluations in rats confirmed significantly improved bioavailability, with a 3.8-fold increase in AUC for CUR and a 6.6-fold increase for PTX. …”

Data Sheet 1_Non-targeted metabolomics-mediated elucidation of metabolite changes in Polygonatum kingianum during traditional steaming with black beans.zip by Haiyan Zhu (110483)

“…Compared to the raw PK, the P3 stage exhibited significant increases in saponins, total sugars, organic acids, and flavonoids by 21.29, 35.02, 49.13, and 44.76%, respectively (p < 0.05), reducing sugars showed a remarkable increase of 160.94-fold (p < 0.01), while polysaccharides decreased significantly by 43.33% (p < 0.01).…”

Design, synthesis and biological evaluation of marine naphthoquinone-naphthol derivatives as potential anticancer agents by Yujuan Li (554062)

“…Among these, Compound <b>13</b>, featuring an oxopropyl group at the <i>ortho</i>-position of quinone group, exhibited the most potent inhibitory effects on HCT116, PC9, and A549 cells, with IC₅₀ values decreasing from 5.27 to 1.18 μM (4.5-fold increase), 6.98 to 0.57 μM (12-fold increase), and 5.88 to 2.25 μM (2.6-fold increase), respectively, compared to compound <b>5</b>. …”

Image 1_The change of bacterial community structure helped Salvia miltiorrhiza alleviate the pressure of drought stress.png by Hai Wang (310051)

“…Inoculated plants exhibited a 3.61-fold increase in biomass compared to the uninoculated controls. …”

Genotoxic Mechanisms of Erythrophleum suaveolens Stem Bark Extracts and Fractions in MCF-7 Breast Cancer Cells via Mitochondrial and Non-Mitochondrial Pathways by Lateef Sulaimon (21706283)

“…After 72 hours, ESSB-treated MCF-7 cells showed a significant (p < 0.05) increase in DNA fragmentation and comet tail DNA percentages (flavonoids induced a 1.21-fold increase in comet tail length). …”

QbD-based co-loading of paclitaxel and imatinib mesylate by protamine-coated PLGA nanoparticles effective on breast cancer cells by Neha Laxane (19851759)

“…</p> <p>Roughly 30-fold increase in cellular uptake was obtained as compared with free drugs.…”

Figure S1-S21 from miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5 by Verena Stiegelbauer (4582930)

“…Supplementary Figure S11 (A) Decreased miR-196b-5p expression resulted in increased invasion in HCT116 cells as measured by transwell invasion assay. …”

Presentation 1_Global patterns of change in the burden of malnutrition in older adults from 1990 to 2021 and the forecast for the next 25 years.pdf by Le Li (356426)

“…</p>Results<p>In 2021, over 97.60 million cases of malnutrition among the elderly were reported globally, a 1.2-fold increase from 44.36 million cases in 1990. …”

Supplementary Tables S1 and S2 by Thomas Clanton (9323303)

“…In the second hour of exposure, though G-CSF, IL-6, KC(CXCL1) and MCP-1(CCL2) were elevated nearly 5-10-fold compared to the first hour, only MCP-1 decreased secretion in LyzMyd88^-/- muscles. …”

Proteomics analysis comparing dsProsβ1- and dsmGFP-fed cabbage stem flea beetle adults. by Doga CEDDEN (12675286)

“…Proteins with fewer than three peptide counts were discarded. Statistical significance was set at adjusted P < 0.05, with significantly altered proteins defined by LogFold2 > 1 (increased) or LogFold2 < -1 (decreased). …”