Design of experiments for the optimization of sample preparation for bottom-up targeted protein LC-MS/MS workflows حسب Szabolcs Szarka (1326471)

"…</p> <p>DOE screening revealed that urea made the biggest improvement on the surrogate peptide responses, while guanidine significantly suppressed them. DOE optimization resulted in a 2-, 10-, 10- and 50-fold response increase for the respective DTLM, FNWY, TPEV and VVSV surrogate peptide even after a short, <3-h sample preparation, when compared to a legacy method that required 2-day preparation.…"

Dataset for manuscript "Microgeographic variation in gene expression plasticity under osmotic stress in wild eastern oyster juveniles (<i>Crassostrea virginica</i>)" حسب Avi Simon (21539672)

"…Low salinity conditions contribute significantly to mortality in the species and stressful upper bay episodes of extended hypo-salinity are expected to increase in frequency under future climate conditions. …"

Oxaloacetate (OAA) flux into gluconeogenic arm and serine synthesis regulate GSH homeostasis. حسب Manisha Goyal (6339704)

"…Data is presented as median plots (****p < 0.0001 and ns is non-significant). Mann-Whitney test is applied for <b>P</b>-<b>R</b>. …"

Data Sheet 1_Particulate matter pollution and older adult health: global trends and disparities, 1991–2021.docx حسب Qiong Yi (3931826)

"…Females consistently experienced higher age-standardized DALYs rate than males for both APMP and HAP-SF across all regions and years. APMP burden showed a weak negative correlation with the Socio-demographic Index (SDI) at the regional level (r = −0.25, p < 0.001) but no significant correlation at the country level. …"

Image 1_Effect of hypoxia-induced mIL15 expression on expansion and memory progenitor stem-like TILs in vitro.tif حسب Zhen Sun (269397)

"…RNA-Seq data revealed that in TIL-mIL15-IL2 cells, the expression of genes related to T cell differentiation and effector function, including PRDM1, ID2, EOMES, IFNG, GZMB, and TNF, were significantly decreased, whereas the expression of the memory stem-like T cell marker TCF7 was significantly increased. …"

FLEXI interactions with RNA-binding proteins. حسب Jun Yao (9646)

"…RNA-binding sites: I, within introns corresponding to FLEXIs; SS-I and SS-E, bimodally enriched across the 5’- and 3’ splice sites in unspliced pre-mRNAs with the midpoints in the intron or flanking exon (SS-I and SS-E, respectively; Figs <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.g004" target="_blank">4A</a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.s011" target="_blank">S11</a>). mRNA levels, RBPs whose knockdown resulted in significant difference in mRNA levels (increased or decreased, DESeq2 |LFC|≥1, adjusted p≤0.05) from host gene of FLEXIs with a binding site for that RBP compared to those genes whose transcripts lacked a binding site for the same RBPs based on ENCODE RBP-knockdown datasets (p≤0.05 calculated by Fisher’s exact test; <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.s013" target="_blank">S13 Fig</a>). …"

Preeclamptic plasma disrupts endothelial function and promotes inflammation in endothelial cells: beneficial effects of glibenclamide and MCC950 in this scenario حسب Karoliny Nune Santos (21752603)

"…<p>Preeclampsia (PE) is characterized by systemic endothelial dysfunction and remains a significant clinical challenge. Activation of NLRP3 inflammasome, reactive oxygen species (ROS) production, and pyroptosis and autophagy are important mechanisms in this condition. …"

Data Sheet 1_Comparative analysis of proteomics and transcriptomics reveals novel mechanism underlying the antibacterial activity and immune-enhancing properties of horse milk.zip حسب Xueshan Chen (17477633)

"…KEGG analysis showed that horse milk contained abundant antimicrobial associated proteins relevant to pathogenic bacterial resistance, leading to the decreased risk of pathogenic diseases. A higher accumulation of proteins associated with caffeine metabolism, amino acid biosynthesis, and glycolysis/gluconeogenesis in horse milk contributes to its distinctive flavor. …"

Table 2_Brown adipocyte exosome - derived C22:6 inhibits the IL-1β signaling pathway to alleviate rheumatoid arthritis.docx حسب Rui Jiang (264894)

"…Introduction<p>Rheumatoid arthritis (RA) is an autoimmune disorder characterized by significant disability and teratogenic effects, for which there are few effective curative therapies. …"

Data Sheet 1_EURAD state-of-the-art report: thermo-hydro-mechanical behaviour of clay buffers at high temperatures.pdf حسب María Victoria Villar (20955281)

"…The clay mineralogy was significantly preserved. The slight changes observed in the other properties were opposite depending on the heating conditions: in the case of evaporation, the cation exchange capacity, specific surface area, sorption coefficients, and sometimes swelling pressure decreased. …"

Data Sheet 1_Increased epicardial tissue and reduced TAPSE and MAPSE scores in borderline personality disorders. Early indicators for cardiovascular risk?.pdf حسب Charlotte F. M. Schaefer (21466880)

"…Additionally, significant decreases in right (TAPSE) and left (MAPSE) ventricular function, albeit within the normal range, were measured in BPD patients. …"

Data Sheet 2_Divergent trends and regional disparities in PM2.5 and O3 health economic burdens in China, 2013–2023: an integrated assessment with policy implications.zip حسب Ziqi Tang (10904159)

"…Conversely, O₃-related mortality exhibited a significant upward trend. At reference concentrations of 0 and 60 μg/m³, all-cause mortality increased by 24.25% (365,084 cases) and 79.70% (372,724 cases), respectively. …"

Table 1_Brown adipocyte exosome - derived C22:6 inhibits the IL-1β signaling pathway to alleviate rheumatoid arthritis.docx حسب Rui Jiang (264894)

"…Introduction<p>Rheumatoid arthritis (RA) is an autoimmune disorder characterized by significant disability and teratogenic effects, for which there are few effective curative therapies. …"

Table 1_Research on the effect of LAMP1 in the development and progression of ccRCC and its potential mechanism with LC3C-mediated autophagy.docx حسب Xiongbao Wang (12508462)

"…</p>Results<p>Bioinformatics analysis revealed significant underexpression of LAMP1 in ccRCC (P<0.001), which correlated with poorer prognosis. …"

Table1_Leaf functional traits highlight phenotypic variation of two tree species in the urban environment.xlsx حسب Ahram Cho (20437850)

"…Norway Maple gas exchange values decreased as the growing season progressed, as expected by ontogeny. …"

Pathogenicity and transmissibility differences in goose-originated subgenotype 3 duck Tembusu virus in goose embryos and 3-day-old goslings حسب Ziqiao Zhao (18785775)

"…In the autumn of 2022, an outbreak of an infectious disease resembling DTMUV was reported in Guangdong Province, China, which caused significantly high mortality in goose embryos, and decreased egg production. …"

Data Sheet 1_Divergent trends and regional disparities in PM2.5 and O3 health economic burdens in China, 2013–2023: an integrated assessment with policy implications.zip حسب Ziqi Tang (10904159)

"…Conversely, O₃-related mortality exhibited a significant upward trend. At reference concentrations of 0 and 60 μg/m³, all-cause mortality increased by 24.25% (365,084 cases) and 79.70% (372,724 cases), respectively. …"

Data for the manuscript entitled "The interrelation between family environment, attributional style and aggression related to emotional disorder among children and adolescents" حسب Mohammad Farris Iman Leong Bin Abdullah (10212443)

"…Parental psychological control—where parents manipulate and constrain children’s thoughts and emotions without responding to their needs—has been identified as a significant risk factor for aggression. Attributional style describes an individual’s habitual way of explaining causes across situations. …"

Data Sheet 1_White matter functional networks in the developing brain.docx حسب Yali Huang (621760)

"…Significant developmental differences in brain white matter functional networks exist between the two group, characterized by increased inter-network FC, decreased intra-network FC, and higher high-frequency energy distribution. …"

Data Sheet 1_The CD38+HLA-DR+ T cells with activation and exhaustion characteristics as predictors of severity and mortality in COVID-19 patients.docx حسب Qiuyue Long (11381148)

"…</p>Results<p>We revealed a significant increase in CD38⁺HLA-DR⁺ T cells in non-survivor COVID-19 patients, establishing them as an independent risk factor for 28-day mortality. …"