TLR4 is involved in the VCC-induced activation of BMDCs. by Shraddha Gandhi (21001590)

“…Immunoblots shown here are the representatives of three independent experiments. (E-F) Significant decrease in the VCC-mediated IL-6 production in BMDCs, upon pre-neutralization of TLR4 with anti-TLR4 antibody. …”

Data Sheet 1_Efficacy of hemoadsorption in the severe course of COVID-19.docx by Aleksei Yurievitch Yakovlev (20837198)

“…Most importantly, the hemoadsorption with Efferon CT was safe and resulted in a significant decrease in the mortality of severe COVID-19 patients.…”

Data Sheet 1_Apheresis for the treatment of relapses in MS and NMOSD: reduced antibody reactivities, gene expression changes and potential clinical response indicators.pdf by Michael Hecker (51971)

“…</p>Conclusion<p>Our data reveal that therapeutic apheresis in MS rapidly leads to a significant decrease in IgG reactivities against EBNA1 (391-410) and cross-reactive targets such as GlialCAM (370-389) and also has an impact on the gene expression of B cells and T cells. …”

Image 1_Age-related obesity and inflammaging in cats.pdf by Miki Kobayashi (16749381)

“…Severely obese cats show excessive visceral fat accumulation, significantly increased triglyceride, free fatty acids, and TNF-α plasma concentrations as pro-inflammatory markers, and a significant decrease in adiponectin. …”

Lepidine potentiates the antidiabetic effect of metformin in nicotinamide/streptozotocin-induced diabetic male rats by Ayman S. Soliman (20718514)

“…Both lepidine and metformin treated diabetic rats showed a significant decrease in fasting blood glucose (FBG), amelioration of serum lipid profile, increase in serum insulin, and C-peptide , and downregulation in the elevated serum tumour necrosis α (TNF-α) level in association with the improvement in the pancreatic islet integrity and function. …”

Table 1_Modulatory effects of black jujube melanoidins on gut microbiota and metabolic pathways in high-fat diet-induced obesity.docx by Xi Che (21248720)

“…MLD also protected the liver, as evidenced by a 16.4% decrease in alanine aminotransferase (ALT) levels and a 29.6% decrease in aspartate aminotransferase (AST) levels (p < 0.05). …”

The Therapeutic Effects of Purified Cortrophin Gel on Experimental Autoimmune Uveitis by Andrew W. Taylor (10179360)

“…In parallel, the retinas of the treated mice had a significant decrease in the histology scores. …”

Table1_Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota.XLSX by Xin Yang (104842)

“…Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut–brain axis as a therapeutic target. …”

DataSheet2_Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota.zip by Xin Yang (104842)

“…Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut–brain axis as a therapeutic target. …”

DataSheet1_Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota.zip by Xin Yang (104842)

“…Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut–brain axis as a therapeutic target. …”

Table2_Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota.XLSX by Xin Yang (104842)

“…Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut–brain axis as a therapeutic target. …”

Table 1_Effects of ibuprofen and microplastics on movement, growth and reproduction in the freshwater snail Physella acuta.xlsx by Daniel Elías (20506310)

“…While no significant effects were observed on movement or number of egg clusters, there was a significant decrease in growth when snails were exposed to microplastics or the combination of microplastics and ibuprofen (p = 0.021). …”

Image 1_Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.jpg by Tianle Cheng (20788417)

“…We identified four neutrophil subtypes—pro-inflammatory, anti-inflammatory, mature, and immature—revealing a significant increase in pro-inflammatory neutrophils in sepsis (40.53% versus 4.19% in controls) and a decrease in anti-inflammatory neutrophils (18.43% versus 27.04%). …”

Image 2_Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.jpg by Tianle Cheng (20788417)

“…We identified four neutrophil subtypes—pro-inflammatory, anti-inflammatory, mature, and immature—revealing a significant increase in pro-inflammatory neutrophils in sepsis (40.53% versus 4.19% in controls) and a decrease in anti-inflammatory neutrophils (18.43% versus 27.04%). …”

Data Sheet 1_Circulating CD8 T cells from patients with mild-to-moderate psoriasis are functionally impaired.docx by Yiqiao Chen (16964252)

“…In contrast, CD69, IFNγ, and Granzyme B were significantly decreased in anti-CD3/CD28-activated CD8 T cell subsets. …”

Data Sheet 2_Circulating CD8 T cells from patients with mild-to-moderate psoriasis are functionally impaired.docx by Yiqiao Chen (16964252)

“…In contrast, CD69, IFNγ, and Granzyme B were significantly decreased in anti-CD3/CD28-activated CD8 T cell subsets. …”

Separable Microneedle Patch Integrated with the Dictamnine-Loaded Copper MOF Nanozyme for Atopic Dermatitis Treatment by Shuyun Liu (692804)

“…In vitro release studies demonstrated ROS-responsive Dic release of 86.80 ± 4.83% over 48 h under AD pathology-mimicking conditions. In a 1-Chloro-2,4-dinitrochlorobenzene (DNCB)-induced AD mouse model, the Dic@pCu-HA MN significantly reduced oxidative stress (8-OHdG: 85.1 ± 7.0% decrease), suppressed pro-inflammatory cytokines (IL-4: 70.0 ± 7.8% decrease vs control), and restored skin barrier integrity. …”

Separable Microneedle Patch Integrated with the Dictamnine-Loaded Copper MOF Nanozyme for Atopic Dermatitis Treatment by Shuyun Liu (692804)

“…In vitro release studies demonstrated ROS-responsive Dic release of 86.80 ± 4.83% over 48 h under AD pathology-mimicking conditions. In a 1-Chloro-2,4-dinitrochlorobenzene (DNCB)-induced AD mouse model, the Dic@pCu-HA MN significantly reduced oxidative stress (8-OHdG: 85.1 ± 7.0% decrease), suppressed pro-inflammatory cytokines (IL-4: 70.0 ± 7.8% decrease vs control), and restored skin barrier integrity. …”

Separable Microneedle Patch Integrated with the Dictamnine-Loaded Copper MOF Nanozyme for Atopic Dermatitis Treatment by Shuyun Liu (692804)

“…In vitro release studies demonstrated ROS-responsive Dic release of 86.80 ± 4.83% over 48 h under AD pathology-mimicking conditions. In a 1-Chloro-2,4-dinitrochlorobenzene (DNCB)-induced AD mouse model, the Dic@pCu-HA MN significantly reduced oxidative stress (8-OHdG: 85.1 ± 7.0% decrease), suppressed pro-inflammatory cytokines (IL-4: 70.0 ± 7.8% decrease vs control), and restored skin barrier integrity. …”

Separable Microneedle Patch Integrated with the Dictamnine-Loaded Copper MOF Nanozyme for Atopic Dermatitis Treatment by Shuyun Liu (692804)

“…In vitro release studies demonstrated ROS-responsive Dic release of 86.80 ± 4.83% over 48 h under AD pathology-mimicking conditions. In a 1-Chloro-2,4-dinitrochlorobenzene (DNCB)-induced AD mouse model, the Dic@pCu-HA MN significantly reduced oxidative stress (8-OHdG: 85.1 ± 7.0% decrease), suppressed pro-inflammatory cytokines (IL-4: 70.0 ± 7.8% decrease vs control), and restored skin barrier integrity. …”