Data Sheet 1_NOP agonist AT-403 promoted sleep in lactic acid-induced acute pain model.pdf by Bethany E. Pierce (11063904)

“…<p>The majority of patients with acute pain experience sleep disturbances that persist despite analgesic treatments such as mu opioid receptor (MOP) agonists and non-steroidal anti-inflammatory drugs (NSAIDs). Further, sleep disturbances increase pain sensitivity, demonstrating a bi-directional relationship between pain and sleep. …”

COMPOSITIONS AND METHODS FOR TREATMENT OF NEUROLOGICAL DISEASE by Janice Keramedjian (19726261)

“…In some preferred embodiments, these have been designed using dehydroascorbic acid, ascorbic acid and amino acids as carriers that result in a significant increase in brain MMF concentration and mitochondrial biogenesis activity. …”

The association of piR-651 and piR-823 on metastatic and invasive characteristics of triple negative breast cancer cells by Çağrı Öner (3152334)

“…The expressions of Ki-67, HIF-1α, MMP-2, and MMP-9 genes were measured at 48 h, when both cell lines exhibited the most significant effects of inhibition. The optimal time for proliferation of anti-piR-651 and anti-piR-823 transfected MDA-MB-231 cells was determined to be at 48 h, as indicated by decreased motility and invasion assay results (<i>p</i> < 0.001). …”

Table 1_Serum levels of interleukin-17, -18, -22, and -25 in patients with bullous pemphigoid before and after treatment.xlsx by Xinyi Hong (8181177)

“…</p>Results<p>The mean serum levels of IL-17, IL-18, IL-22, IL-25, and EOS percentage in BP patients were higher than those in healthy controls (all p < 0.001), and all of these levels decreased after treatment (all p < 0.001). There was no statistically significant difference in the titer of anti-BP180 or anti-BP230 antibodies before and after treatment. …”

Table 2_Serum levels of interleukin-17, -18, -22, and -25 in patients with bullous pemphigoid before and after treatment.xlsx by Xinyi Hong (8181177)

“…</p>Results<p>The mean serum levels of IL-17, IL-18, IL-22, IL-25, and EOS percentage in BP patients were higher than those in healthy controls (all p < 0.001), and all of these levels decreased after treatment (all p < 0.001). There was no statistically significant difference in the titer of anti-BP180 or anti-BP230 antibodies before and after treatment. …”

Data Sheet 1_hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways.doc by Yan Yu (56143)

“…Background<p>Breast cancer remains a leading cause of mortality among women worldwide, with existing therapeutic options often accompanied by significant side effects and a persistent risk of disease recurrence. …”

Table 2_Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies.docx by Yutao Liu (87989)

“…The primary outcomes included relapse rates, Expanded Disability Status Scale (EDSS) scores, and survival outcomes.</p>Results<p>(1) Anti-CTD Abs (+): higher proportion of female patients, increased relapse frequency; decreased red blood cell (RBC) count and aspartate aminotransferase (AST) levels. (2) ATAbs (+): greater incidence of acute brainstem syndrome (ABS); reduced peripheral leukocyte, neutrophil, and lymphocyte counts; elevated serum urea levels. (3) Double (+): marked female predominance, higher incidence of ABS, decreased RBC count, hemoglobin (Hb) levels, and cerebrospinal fluid (CSF) chloride concentration; elevated serum urea. (4) AQP4-IgG association: AQP4-IgG-positive patients were more frequently female, with higher prevalence of anti-CTD Abs positivity but lower prevalence of ATAbs positivity. (5) Prognostic analysis: both double-positive and single-antibody-positive groups showed higher disability (EDSS ≥4.0/≥6.0) compared with antibody-negative patients, although no significant differences were observed between the two single-antibody subgroups. (6) Multivariate analysis identified combined antibody positivity (OR = 16.292), baseline EDSS score (OR = 3.179), and age at onset (OR = 1.052) as independent predictors of poor clinical outcomes.…”

Table 4_Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies.docx by Yutao Liu (87989)

“…The primary outcomes included relapse rates, Expanded Disability Status Scale (EDSS) scores, and survival outcomes.</p>Results<p>(1) Anti-CTD Abs (+): higher proportion of female patients, increased relapse frequency; decreased red blood cell (RBC) count and aspartate aminotransferase (AST) levels. (2) ATAbs (+): greater incidence of acute brainstem syndrome (ABS); reduced peripheral leukocyte, neutrophil, and lymphocyte counts; elevated serum urea levels. (3) Double (+): marked female predominance, higher incidence of ABS, decreased RBC count, hemoglobin (Hb) levels, and cerebrospinal fluid (CSF) chloride concentration; elevated serum urea. (4) AQP4-IgG association: AQP4-IgG-positive patients were more frequently female, with higher prevalence of anti-CTD Abs positivity but lower prevalence of ATAbs positivity. (5) Prognostic analysis: both double-positive and single-antibody-positive groups showed higher disability (EDSS ≥4.0/≥6.0) compared with antibody-negative patients, although no significant differences were observed between the two single-antibody subgroups. (6) Multivariate analysis identified combined antibody positivity (OR = 16.292), baseline EDSS score (OR = 3.179), and age at onset (OR = 1.052) as independent predictors of poor clinical outcomes.…”

Table 1_Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies.docx by Yutao Liu (87989)

“…The primary outcomes included relapse rates, Expanded Disability Status Scale (EDSS) scores, and survival outcomes.</p>Results<p>(1) Anti-CTD Abs (+): higher proportion of female patients, increased relapse frequency; decreased red blood cell (RBC) count and aspartate aminotransferase (AST) levels. (2) ATAbs (+): greater incidence of acute brainstem syndrome (ABS); reduced peripheral leukocyte, neutrophil, and lymphocyte counts; elevated serum urea levels. (3) Double (+): marked female predominance, higher incidence of ABS, decreased RBC count, hemoglobin (Hb) levels, and cerebrospinal fluid (CSF) chloride concentration; elevated serum urea. (4) AQP4-IgG association: AQP4-IgG-positive patients were more frequently female, with higher prevalence of anti-CTD Abs positivity but lower prevalence of ATAbs positivity. (5) Prognostic analysis: both double-positive and single-antibody-positive groups showed higher disability (EDSS ≥4.0/≥6.0) compared with antibody-negative patients, although no significant differences were observed between the two single-antibody subgroups. (6) Multivariate analysis identified combined antibody positivity (OR = 16.292), baseline EDSS score (OR = 3.179), and age at onset (OR = 1.052) as independent predictors of poor clinical outcomes.…”

Table 3_Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies.docx by Yutao Liu (87989)

“…The primary outcomes included relapse rates, Expanded Disability Status Scale (EDSS) scores, and survival outcomes.</p>Results<p>(1) Anti-CTD Abs (+): higher proportion of female patients, increased relapse frequency; decreased red blood cell (RBC) count and aspartate aminotransferase (AST) levels. (2) ATAbs (+): greater incidence of acute brainstem syndrome (ABS); reduced peripheral leukocyte, neutrophil, and lymphocyte counts; elevated serum urea levels. (3) Double (+): marked female predominance, higher incidence of ABS, decreased RBC count, hemoglobin (Hb) levels, and cerebrospinal fluid (CSF) chloride concentration; elevated serum urea. (4) AQP4-IgG association: AQP4-IgG-positive patients were more frequently female, with higher prevalence of anti-CTD Abs positivity but lower prevalence of ATAbs positivity. (5) Prognostic analysis: both double-positive and single-antibody-positive groups showed higher disability (EDSS ≥4.0/≥6.0) compared with antibody-negative patients, although no significant differences were observed between the two single-antibody subgroups. (6) Multivariate analysis identified combined antibody positivity (OR = 16.292), baseline EDSS score (OR = 3.179), and age at onset (OR = 1.052) as independent predictors of poor clinical outcomes.…”

Image 2_Chronic hexavalent chromium exposure induces oxidative stress-mediated molecular cascades in Thymallus grubii gills: evidence from integrated transcriptomics and metabolomi... by Xinchi Shang (11982840)

“…Disorders of arachidonic acid metabolism led to the release of proinflammatory metabolites (such as thromboxane A2 and prostaglandin J2), and decreased levels of reduced glutathione.…”

Image 3_Chronic hexavalent chromium exposure induces oxidative stress-mediated molecular cascades in Thymallus grubii gills: evidence from integrated transcriptomics and metabolomi... by Xinchi Shang (11982840)

“…Disorders of arachidonic acid metabolism led to the release of proinflammatory metabolites (such as thromboxane A2 and prostaglandin J2), and decreased levels of reduced glutathione.…”

Table 1_Chronic hexavalent chromium exposure induces oxidative stress-mediated molecular cascades in Thymallus grubii gills: evidence from integrated transcriptomics and metabolomi... by Xinchi Shang (11982840)

“…Disorders of arachidonic acid metabolism led to the release of proinflammatory metabolites (such as thromboxane A2 and prostaglandin J2), and decreased levels of reduced glutathione.…”

Image 4_Chronic hexavalent chromium exposure induces oxidative stress-mediated molecular cascades in Thymallus grubii gills: evidence from integrated transcriptomics and metabolomi... by Xinchi Shang (11982840)

“…Disorders of arachidonic acid metabolism led to the release of proinflammatory metabolites (such as thromboxane A2 and prostaglandin J2), and decreased levels of reduced glutathione.…”

Image 1_Chronic hexavalent chromium exposure induces oxidative stress-mediated molecular cascades in Thymallus grubii gills: evidence from integrated transcriptomics and metabolomi... by Xinchi Shang (11982840)

“…Disorders of arachidonic acid metabolism led to the release of proinflammatory metabolites (such as thromboxane A2 and prostaglandin J2), and decreased levels of reduced glutathione.…”

CuSO₄ data tables. by Saima Naz (5066162)

“…A significant (p < 0.05) increase was observed in oxidative stress parameters (ROS, TBARS) whereas the activity of anti-oxidant enzymes (SOD, POD, GSH, CAT) was significantly (p < 0.05) decreased in the gills, brain, liver and kidneys of fish exposed to 0.56 µg/L concentration of CuSO₄. …”

Supplemental file for Training alters cytokine and soluble receptor responses by Jeremy Ducharme (20174820)

“…Together these findings highlight a novel potential anti-inflammatory adaptation such that trained men present a blunted inflammatory response by both reduced inflammatory cytokines and increased soluble receptors post-exercise compared to untrained men.…”

Data Sheet 1_Resistance characteristics of culture-positive tuberculosis from 2015 to 2022.xlsx by Zhenzhen Wang (250368)

“…The findings provide a data basis for developing more precise and regionally tailored anti-TB treatment regimens.…”

Figure 4 from Impact of Glucocorticoids on Immune Checkpoint Inhibitor Efficacy and Circulating Biomarkers in Non–Small Cell Lung Cancer Patients by Lauren Polyakov (21672045)

“…<p>Continued use of corticosteroids during anti–PD-L1 therapy correlates with decreased survival in a preclinical model. …”

Cilium disassembly defects were rescued with ectopic expression of CCDC66 but not CEP104. by Jovana Deretic (13113617)

“…(Welch <i>t</i> test <i>p</i> value ns: not significant). <b>(D)</b> IMCD3::CEP104-BirA*-Flag were transduced with control and CCDC66-targeting shRNA, selected and seeded on coverslips. …”