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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
anti decrease » nn decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
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1261
Data Sheet 1_miR-223 alleviates DSS-induced colitis by prompting macrophage M2 polarization through PPAR-γ/FOXO1 signaling.pdf
Published 2025“…</p>Results<p>Histopathological analysis showed that miR-223 agomir significantly attenuated DSS-induced colon damage. Proinflammatory cytokines (TNF-α, IL-1β, IL-6) increased in DSS mice, while anti-inflammatory IL-10 decreased—trends reversed by miR-223 supplementation at mRNA/protein levels. …”
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1262
Image 1_TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury.pdf
Published 2025“…Intriguingly, Jα18<sup>−/−</sup> mice, which are completely deficient in invariant natural killer T (iNKT) cells, exhibited not only significantly less severe lung inflammation but also a notably higher degree of anti-inflammatory Arg1<sup>+</sup> M2 macrophages infiltration when compared with their LPS-sensitized wild-type counterparts.…”
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1263
Unveiling the molecular legacy of transient insulin resistance: Implications for hepatic metabolic adaptability (Sup Tables). Berthier et al. J. Hepatol. 2025
Published 2025“…By extension, any transient exposure to compounds altering circadian rhythmicity, such as anti-depressants, might predispose to a compromised metabolic response to an unbalanced diet later in life.…”
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1264
Table 1_The association between dietary creatine intake and cancer in U.S. adults: insights from NHANES 2007–2018.docx
Published 2025“…Background<p>Creatine has anti-inflammatory, antioxidant, and immunomodulatory effects. …”
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1265
Table1_Gut microbiota and metabolomics unveil the mechanisms of Lomatogonium rotatum in ameliorating visceral fat and serum lipids in high-fat diet-induced obese mice.XLSX
Published 2024“…<p>Lomatogonium rotatum (LR) is a folk medicinal herb traditionally used as a lipid-lowering and anti-obesity agent; but its pharmacological mechanism is unclear. …”
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1266
Data Sheet 1_Chrysin sensitizes glioblastoma cells and spheroids to temozolomide treatment by reducing EMT and stemness phenotypes, as well as targeting multidrug resistance protei...
Published 2025“…In 3D spheroid models, co-treatments significantly impaired growth and viability.</p>Conclusion<p>These findings suggest that CHR may be a promising adjuvant to TMZ therapy, providing novel insights into overcoming chemoresistance in GB treatment.…”
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1267
Conditional Knockout of Serine Racemase in Microglia Alleviates Alzheimer -like Pathology and Behavior by Reducing Neuroinflammation through Enhancing Histone Lactylation
Published 2025“…Further, addition of C646, a p300 inhibitor or oxamate, an inhibitor of lactate dehydrogenase A, significantly reversed arginase1 or interleukin-10 mRNA levels in srr-/- microglia. …”
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1268
Supporting data for “<b>Human Lipocalin-2 Variants: Therapeutic Evaluations</b>”
Published 2024“…</p><p dir="ltr">Following a high-fat diet, our findings demonstrated that C87A levels were significantly elevated in cardiac and epididymal white adipose tissue (eWAT). …”
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1269
Table 1_Neonatal supplementation of oleamide during suckling ameliorates maternal postpartum sleep interruption-induced neural impairment and endocannabinoid dysfunction in early a...
Published 2025“…Introduction<p>Postpartum sleep disturbances in women are common and can significantly affect maternal mental health and breastfeeding. …”
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1270
Data Sheet 1_Comparative hepatoprotective effects of AMK and PAMK via Nrf2 signaling in broiler breeders.pdf
Published 2025“…(AMK) and its purified polysaccharide fraction (PAMK) are known for their antioxidant, anti-inflammatory, and hepatoprotective properties, showing potential benefits for poultry liver health. …”
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1271
Table 2_Neonatal supplementation of oleamide during suckling ameliorates maternal postpartum sleep interruption-induced neural impairment and endocannabinoid dysfunction in early a...
Published 2025“…Introduction<p>Postpartum sleep disturbances in women are common and can significantly affect maternal mental health and breastfeeding. …”
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1272
Data Sheet 1_Allicin ameliorates acute myocardial infarction in rats by modulating calcium homeostasis in cardiomyocytes through the induction of hydrogen sulfide production.docx
Published 2025“…</p>Results<p>The results indicate that allicin significantly enhanced cardiac function, raised H<sub>2</sub>S levels in myocardial tissue and serum, reduced necrosis tissue size, decreased myocardial enzyme levels, and improved myocardial pathological changes. …”
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1273
Presentation 1_Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice.zip
Published 2025“…The related mechanisms were confirmed using lipid-loaded HepG2 cells together with PCSK9 siRNA, alirocumab (anti-PCSK9 antibody), and/or a p38-MAPK inhibitor. …”
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1274
Table 1_Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice.docx
Published 2025“…The related mechanisms were confirmed using lipid-loaded HepG2 cells together with PCSK9 siRNA, alirocumab (anti-PCSK9 antibody), and/or a p38-MAPK inhibitor. …”
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1275
Table2_Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer.xlsx
Published 2024“…Finally, the low-risk group was more sensitive to anti-cancer drugs. The mRNA levels of PTPRD-AS1, SPAG5-AS1, FAM27E3, and AC018647.3 were significantly over-expressed in OC cell lines (SKOV3, A2780, CAOV3) in comparison to normal IOSE-80 cells. …”
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1276
Table1_Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer.docx
Published 2024“…Finally, the low-risk group was more sensitive to anti-cancer drugs. The mRNA levels of PTPRD-AS1, SPAG5-AS1, FAM27E3, and AC018647.3 were significantly over-expressed in OC cell lines (SKOV3, A2780, CAOV3) in comparison to normal IOSE-80 cells. …”
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1277
DataSheet1_Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer.docx
Published 2024“…Finally, the low-risk group was more sensitive to anti-cancer drugs. The mRNA levels of PTPRD-AS1, SPAG5-AS1, FAM27E3, and AC018647.3 were significantly over-expressed in OC cell lines (SKOV3, A2780, CAOV3) in comparison to normal IOSE-80 cells. …”
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1278
Full name and abbreviation.
Published 2025“…</p><p>Results and conclusion</p><p>The results indicated that oxidative stress and immune response factor expressions quantity in Gallus gallus decreased significantly after 14 days of treatment, compared with model group, the low-dose treatment group’s SOD1, SOD3, GPX1, GPX2, GSR, H6DP, and HO-1 genes in liver were downregulated by 36.03%, 40.01%, 45.86%, 40.79%, 37.68%, 25.04%, and 29.89%, the IL-1, IL-2, IL-4, IL-6, IgA, IgM, and IgG genes in blood and spleen were downregulated by 26.59%, 34.19%, 21.19%, 28.18%, 35.93%, 12.67%, 21.81 and 35.93%, 22.85%, 21.19%, 28.78%, 35.93%, 15.36%, 29.73%. …”
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1279
The animal experimental protocol.
Published 2025“…</p><p>Results and conclusion</p><p>The results indicated that oxidative stress and immune response factor expressions quantity in Gallus gallus decreased significantly after 14 days of treatment, compared with model group, the low-dose treatment group’s SOD1, SOD3, GPX1, GPX2, GSR, H6DP, and HO-1 genes in liver were downregulated by 36.03%, 40.01%, 45.86%, 40.79%, 37.68%, 25.04%, and 29.89%, the IL-1, IL-2, IL-4, IL-6, IgA, IgM, and IgG genes in blood and spleen were downregulated by 26.59%, 34.19%, 21.19%, 28.18%, 35.93%, 12.67%, 21.81 and 35.93%, 22.85%, 21.19%, 28.78%, 35.93%, 15.36%, 29.73%. …”
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1280
Table 1_Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance.xlsx
Published 2025“…Background and objective<p>Qinggan Yipi Capsule (QgYp) is a hospital preparation that has been used for many years in the treatment of chronic liver diseases. …”