Prohibitin2 knockdown decreases glioma malignant phenotypes and radio-resistance by inhibiting mitophagy by Xuefei Xue (16496943)

“…Additionally, PHB2 regulated the expression of PGAM5 and PINK1 by directly binding to PARL.</p> <p>Our findings revealed that PHB2 knockdown decreased glioma malignant phenotypes and radio-resistance by inhibiting mitophagy <i>via</i> PARL–PGAM5–PINK1–Parkin pathway. …”

Extraction of demaging missense mutations from the TCGA Database. by Ashraf Attia Mahmoud (21262201)

Conditional deletion of C/EBP in epidermis results in downregulation of transcripts and pathways associated with lipid biosynthesis in epidermis. by Kevin J. Mills (9270966)

Expression of RBM-26 is disrupted by P80L and L13V missense mutations. by Tamjid A. Chowdhury (14149846)

FLEXI interactions with RNA-binding proteins. by Jun Yao (9646)

“…The grids below the bar graph show reported RBP Functions (red boxes), Intracellular Localization (green boxes), and FLEXI Interactions (blue boxes). RNA-binding sites: I, within introns corresponding to FLEXIs; SS-I and SS-E, bimodally enriched across the 5’- and 3’ splice sites in unspliced pre-mRNAs with the midpoints in the intron or flanking exon (SS-I and SS-E, respectively; Figs <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.g004" target="_blank">4A</a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.s011" target="_blank">S11</a>). mRNA levels, RBPs whose knockdown resulted in significant difference in mRNA levels (increased or decreased, DESeq2 |LFC|≥1, adjusted p≤0.05) from host gene of FLEXIs with a binding site for that RBP compared to those genes whose transcripts lacked a binding site for the same RBPs based on ENCODE RBP-knockdown datasets (p≤0.05 calculated by Fisher’s exact test; <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.s013" target="_blank">S13 Fig</a>). …”

Gene expression omnibus datasets. by Xinyi Xia (7516694)

“…TCMR hub genes, guanylate-binding protein 1 (GBP1) and CD69, showed increased expression. …”

CCND1 is a target gene of miR-1247-3p. by Dequan Wang (6007007)

Schematic presentation <i>M</i>. <i>bovis</i> PG45 5′ nucleotidase and phylogenetic tree of its homologs. by Aga E. Gelgie (17661720)

Image 3_Significance of LRFN4 in prognosis and tumor microenvironment of lung adenocarcinoma.tif by Nana Wang (533812)

Image 2_Significance of LRFN4 in prognosis and tumor microenvironment of lung adenocarcinoma.tif by Nana Wang (533812)

Image 1_Significance of LRFN4 in prognosis and tumor microenvironment of lung adenocarcinoma.jpeg by Nana Wang (533812)

Data Sheet 4_Significance of LRFN4 in prognosis and tumor microenvironment of lung adenocarcinoma.xlsx by Nana Wang (533812)

Data Sheet 2_Significance of LRFN4 in prognosis and tumor microenvironment of lung adenocarcinoma.xlsx by Nana Wang (533812)

Data Sheet 3_Significance of LRFN4 in prognosis and tumor microenvironment of lung adenocarcinoma.xlsx by Nana Wang (533812)

Data Sheet 1_Significance of LRFN4 in prognosis and tumor microenvironment of lung adenocarcinoma.xlsx by Nana Wang (533812)

Table 5_PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.xlsx by Hong-Xing Li (316258)

“…After down expression of PABPN1, mRNA expression levels of MRPS15 and GPx (Glutathione peroxidase) decreased significantly in T24, 5637 HLF and MCF-7 cells.…”

Image 8_PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.tif by Hong-Xing Li (316258)

“…After down expression of PABPN1, mRNA expression levels of MRPS15 and GPx (Glutathione peroxidase) decreased significantly in T24, 5637 HLF and MCF-7 cells.…”

Table 2_PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.xlsx by Hong-Xing Li (316258)

“…After down expression of PABPN1, mRNA expression levels of MRPS15 and GPx (Glutathione peroxidase) decreased significantly in T24, 5637 HLF and MCF-7 cells.…”

Image 3_PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.tif by Hong-Xing Li (316258)

“…After down expression of PABPN1, mRNA expression levels of MRPS15 and GPx (Glutathione peroxidase) decreased significantly in T24, 5637 HLF and MCF-7 cells.…”

Image 6_PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.tif by Hong-Xing Li (316258)

“…After down expression of PABPN1, mRNA expression levels of MRPS15 and GPx (Glutathione peroxidase) decreased significantly in T24, 5637 HLF and MCF-7 cells.…”