Data Sheet 1_Impact of implementing a pediatric early warning system on outcomes in hematopoietic stem cell transplant units in South America and Europe.docx by Monica L. Quijano-Lievano (22808537)

“…CDE post-PEWS were less likely due to respiratory distress (38%, n = 27/71 vs. 23% n = 35/150, p = 0.0348), had fewer organ systems with dysfunction at ICU transfer (median 2 [IQR 1–3] vs. 0 [IQR 0–2], p < 0.001), and had lower PIM2, which indicates a lower severity of illness at ICU transfer (median 5.0 [IQR 1.4–7.9] vs. 1.5 [IQR 1.2–3.4], p < 0.001). There was a non-significant decrease in clinical deterioration event mortality post-PEWS implementation (24%, n = 17/71 vs. 15%, n = 22/150, p = 0.1335).…”

Table_2_Effectiveness of written emotional disclosure interventions for eating disorders: a systematic review and meta-analysis.XLSX by Yufei Wang (171069)

“…The written emotional disclosure intervention can decrease eating disorder symptoms scores (SMD = −0.20, 95% CI [−0.34, −0.05], Z = 2.59, p = 0.01), body dissatisfaction scores (SMD = 0.37, 95% CI [0.21, 0.52], Z = 4.59, p < 0.001), and thin ideal internalization score (SMD = 0.42, 95% CI [0.22, 0.62], Z = 4.12, p < 0.001). …”

Table1_Efficacy and safety of guanxinshutong capsule combined with western medicine on stable angina pectoris: a systematic review and meta-analysis.DOC by Liyuan Yu (5341841)

“…GXST and WM combination was significantly more effective than WM alone across several metrics: clinical efficacy rate (odds ratio [OR] = 4.05, 95% confidence interval [CI] = 3.42–4.80), electrocardiogram improvement (OR = 3.39, 95% CI = 2.35–4.87), enhancement in left ventricular ejection fraction (mean difference [MD] = 1.07, 95% CI = 0.69–1.46), reduction in total cholesterol levels (MD = −0.78, 95% CI = −1.20 to −0.35), decrease in tumor necrosis factor-alpha (MD = −1.36, 95% CI = −2.18 to −0.53), and improvement in Chinese medicine evidence score (OR = 3.77, 95% CI = 2.20–6.43). …”

Data Sheet 3_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.xlsx by Wentong Li (492392)

“…Single-cell resolution analysis showed HSP90AA1 to be specifically overexpressed in oligodendrocytes (72.23%), significantly correlating with glial depletion (4.56% decrease in oligodendrocytes, p<0.01) and aberrant neuronal proliferation (144.23% increase, p=0.0032). …”

Table 2_Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis.docx by Tainã Luís de Souza (21574790)

“…A notable finding was the decrease in the CD68⁺NOS2⁺/CD68⁺Arginase-1⁺ ratio in animals with higher parasite load. …”

Image3_Efficacy and safety of guanxinshutong capsule combined with western medicine on stable angina pectoris: a systematic review and meta-analysis.JPEG by Liyuan Yu (5341841)

“…GXST and WM combination was significantly more effective than WM alone across several metrics: clinical efficacy rate (odds ratio [OR] = 4.05, 95% confidence interval [CI] = 3.42–4.80), electrocardiogram improvement (OR = 3.39, 95% CI = 2.35–4.87), enhancement in left ventricular ejection fraction (mean difference [MD] = 1.07, 95% CI = 0.69–1.46), reduction in total cholesterol levels (MD = −0.78, 95% CI = −1.20 to −0.35), decrease in tumor necrosis factor-alpha (MD = −1.36, 95% CI = −2.18 to −0.53), and improvement in Chinese medicine evidence score (OR = 3.77, 95% CI = 2.20–6.43). …”

Data Sheet 1_Anti-HLA antibodies bound to monocytes altered antibody-mediated platelet phagocytosis and led to mild thrombocytopenia.pdf by Xiuzhang Xu (22363618)

“…Furthermore, the administration of anti-MHC-I antibodies to mice led to a significant decrease in the platelet count within 24 h. …”

Image 1_Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis.jpg by Tainã Luís de Souza (21574790)

“…A notable finding was the decrease in the CD68⁺NOS2⁺/CD68⁺Arginase-1⁺ ratio in animals with higher parasite load. …”

Data Sheet 1_Plasma testosterone concentration is correlated with circulating immune cell abundance in transgender young people on gender-affirming hormone treatment.pdf by Alice A. White (21695726)

“…<p>Sex hormones, such as oestrogen and testosterone, display significant immune modulatory properties. This is highly relevant for transgender (trans) people who undergo gender-affirming hormone (GAH) treatment. …”

Chromosomal partitioning is maintained during intracellular UPEC coccobacilli divisions. by Alaska Pokhrel (9566813)

“…<b>i</b>, FtsZ-mNeonGreen (green) rings do not constrict over unsegregated chromosomes (HupA-RFP, pseudo-coloured magenta) in extracellular rods. Statistical significance was determined by student <i>T</i> test, where **** stars indicate p values less than 0.0001., n.s. = not significant. …”

Data Sheet 4_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.xlsx by Wentong Li (492392)

“…Single-cell resolution analysis showed HSP90AA1 to be specifically overexpressed in oligodendrocytes (72.23%), significantly correlating with glial depletion (4.56% decrease in oligodendrocytes, p<0.01) and aberrant neuronal proliferation (144.23% increase, p=0.0032). …”

Table_1_Effectiveness of written emotional disclosure interventions for eating disorders: a systematic review and meta-analysis.DOCX by Yufei Wang (171069)

“…The written emotional disclosure intervention can decrease eating disorder symptoms scores (SMD = −0.20, 95% CI [−0.34, −0.05], Z = 2.59, p = 0.01), body dissatisfaction scores (SMD = 0.37, 95% CI [0.21, 0.52], Z = 4.59, p < 0.001), and thin ideal internalization score (SMD = 0.42, 95% CI [0.22, 0.62], Z = 4.12, p < 0.001). …”

Table_1_Outcomes of retroperitoneal fibrosis-related hydronephrosis and its risk factors for poor prognosis: a multi-center retrospective cohort study in Chinese patients.DOCX by figshare admin frontiersin (4545187)

“…After 60.43 ± 34.53 months of follow-up, 36 patients had poor prognosis, which was associated with severe kidney impairment, bilateral hydronephrosis and inflammation status (elevated ESR and IgG) at diagnosis by case–control study. eGFR and creatinine were independent risk factors after adjusting for all other significant associations (p = 0.002 and p = 0.067, respectively). …”

Table2_Efficacy and safety of guanxinshutong capsule combined with western medicine on stable angina pectoris: a systematic review and meta-analysis.DOC by Liyuan Yu (5341841)

“…GXST and WM combination was significantly more effective than WM alone across several metrics: clinical efficacy rate (odds ratio [OR] = 4.05, 95% confidence interval [CI] = 3.42–4.80), electrocardiogram improvement (OR = 3.39, 95% CI = 2.35–4.87), enhancement in left ventricular ejection fraction (mean difference [MD] = 1.07, 95% CI = 0.69–1.46), reduction in total cholesterol levels (MD = −0.78, 95% CI = −1.20 to −0.35), decrease in tumor necrosis factor-alpha (MD = −1.36, 95% CI = −2.18 to −0.53), and improvement in Chinese medicine evidence score (OR = 3.77, 95% CI = 2.20–6.43). …”

Image 3_The global burden of neonatal sepsis attributable to air pollution from 1990 to 2021: findings from the global burden of disease study 2021.jpeg by Jiajia Duan (9351878)

“…</p>Conclusion<p>Overall, air pollution remains a significant public health challenge threatening neonatal health. …”

Table 3_Engineered spermidine-secreting Saccharomyces boulardii enhances olfactory memory in Drosophila melanogaster.xlsx by Florance Parweez (22534262)

“…The intracellular levels of polyamines, especially spermidine, decrease in aging. Oral spermidine supplementation has been reported to alleviate aspects of aging-related disease in animal models, including decline in learning and memory. …”

Image 3_Evaluation of the cytotoxicity and antibacterial activity of a synthetic tunicamycin derivative against Mycobacterium avium complex.jpeg by Maria A. Colombatti Olivieri (21362615)

“…Also, low-dose TunR2 treatment of infected macrophages did not significantly decrease Map survival after 48 h of infection. …”

Table_1_Partnership and relationship happiness in endometriosis related chronic pelvic pain: a multicenter case–control study.docx by Samia el Hadad (19844874)

“…</p>Conclusion<p>Given the significance of partnership in dealing with chronic diseases and the connection between symptoms of endometriosis and a decrease in partnership quality, it is essential to incorporate strategies that alleviate the negative impacts on relationships for both partners into medical support.…”

Data Sheet 1_Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss.docx by Joana Saavedra (11327910)

“…We used the AD mouse model AβPPswe/PS1A246E to show that neuronal S100B levels are significantly higher in 10-month-old animals, and cellular assays to demonstrate that Aβ oligomers significantly increase S100B expression in SH-SY5Y cells, but not monomeric or fibrillar Aβ. …”

<b>Cannabinoid Receptor 2 Agonism Demonstrates Therapeutic </b><b>Potential in Experimental Models of Relevance to Diabetic Retinopathy</b> by Cayla D. Ontko (21434062)

“…<i>In vivo</i>, both intraocular and systemic HU-308 administration significantly decreased retinal leukostasis in cytokine-induced inflammation and STZ-induced diabetes. …”