Table 5_The dysbiosis of gut microbiota and dysregulation of metabolites in IgA nephropathy and membranous nephropathy.xlsx حسب Lei Zhang (38117)

"…Notably, both IgAN and MN patients showed a decrease in the abundance of certain specific microbial taxa. …"

Data Sheet 2_Cepharanthine may inhibit the proliferation of prostate cells by blocking the EGFR/PI3K/AKT signaling pathway: comprehensive network analysis, molecular docking, and e... حسب Yin Huang (179237)

"…Celigo counting revealed a significant decrease in both cell lines after 24–96 h of CEP treatment. …"

Data Sheet 1_Enabling immune checkpoint blockade efficacy in T-lymphopenia by restoring CD8 T cell dynamics with IL-7 cytokine therapy.docx حسب Yeon-Woo Kang (18285202)

"…The combination of rhIL-7-hyFc and anti-PD-1 therapy resulted in significant tumor regression and improved mouse survival.…"

Data Sheet 1_Glucocorticoids and immunoglobulin alone or in combination in the treatment of multisystemic inflammatory syndrome in children: a systematic review and network meta-an... حسب Junjie Lin (8379594)

"…</p>Conclusions and relevance<p>GCs monotherapy significantly reduces treatment failure rates and persistent fever duration, while combination therapy significantly reduces the need for adjunctive immunotherapy. …"

Table 4_The dysbiosis of gut microbiota and dysregulation of metabolites in IgA nephropathy and membranous nephropathy.xlsx حسب Lei Zhang (38117)

"…Notably, both IgAN and MN patients showed a decrease in the abundance of certain specific microbial taxa. …"

Data Sheet 1_Cepharanthine may inhibit the proliferation of prostate cells by blocking the EGFR/PI3K/AKT signaling pathway: comprehensive network analysis, molecular docking, and e... حسب Yin Huang (179237)

"…Celigo counting revealed a significant decrease in both cell lines after 24–96 h of CEP treatment. …"

Table1_Safety evaluation of medroxyprogesterone acetate: a pharmacovigilance analysis using FDA adverse event reporting system data.DOCX حسب Luyang Su (20411552)

"…Unforeseen significant AEs such as unintended pregnancy (n = 623; ROR, 6.65; ROR025, 6.1; χ², 2,482.38; PRR, 6.41; EBGM, 5.69; EBGM05, 5.29), bone pain (n = 35; ROR, 13.78; ROR025, 9.4; χ², 311.2; PRR, 13.75; EBGM, 10.59; EBGM05, 7.69), gait disturbance (n = 34; ROR, 2.82; ROR025, 1.99; χ², 37.31; PRR, 2.88; EBGM, 2.7; EBGM05, 2.02), dental caries (n = 15; ROR, 23.16; ROR025, 12.32; χ², 204.26; PRR, 23.14; EBGM, 15.23; EBGM05, 8.98), decrease in blood pressure (n = 15; ROR, 3.88; ROR025, 2.29; χ², 29.35; PRR, 3.88; EBGM, 3.63; EBGM05, 2.33), and osteonecrosis (n = 9; ROR, 23.44; ROR025, 10.36; χ², 123.67; PRR, 23.43; EBGM, 15.35; EBGM05, 7.75) were identified as AEs that were not previously outlined in the prescribing information of the medication.…"

Data_Sheet_2_Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood.PDF حسب Kate Beecher (6688340)

"…The deficits in hippocampal-dependent learning and memory were accompanied by altered hippocampal neurogenesis, with an overall decrease in the proliferation and differentiation of newborn neurons within the dentate gyrus. …"

Bioassay and NMR-HSQC-Guided Isolation and Identification of Phthalide Dimers with Anti-Inflammatory Activity from the Rhizomes of Angelica sinensis حسب Hongyan Wen (9226895)

"…Among them, compound <b>9</b> showed a remarkable inhibitory activity with IC₅₀ values of 425 nM and could significantly decrease IL-1β and IL-6 transcription levels. …"

Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation حسب Huang-Ju Tu (630766)

"…Although the development of DYRK1A inhibitors has significantly advanced in recent years, the selectivity of these drugs remains a critical challenge, potentially impeding further progress. …"

Data_Sheet_1_Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood.PDF حسب Kate Beecher (6688340)

"…The deficits in hippocampal-dependent learning and memory were accompanied by altered hippocampal neurogenesis, with an overall decrease in the proliferation and differentiation of newborn neurons within the dentate gyrus. …"

Bioassay and NMR-HSQC-Guided Isolation and Identification of Phthalide Dimers with Anti-Inflammatory Activity from the Rhizomes of Angelica sinensis حسب Hongyan Wen (9226895)

"…Among them, compound <b>9</b> showed a remarkable inhibitory activity with IC₅₀ values of 425 nM and could significantly decrease IL-1β and IL-6 transcription levels. …"

Effects of Nitro-Substitution on the Spectroscopic and Self-Assembly Properties of BODIPY Dyes حسب Caroline Gwaro (21012411)

"…In a polar organic solvent, nitro-substitution tends to quench the characteristic fluorescence of BODIPYs, while in a nonpolar solvent, significantly higher absolute fluorescence quantum yields are observed. …"

Presentation_1_Src Inhibition Attenuates Neuroinflammation and Protects Dopaminergic Neurons in Parkinson’s Disease Models.PDF حسب Hanyu Yang (8374881)

"…The results showed that inhibition of Src could significantly relieve microgliosis and decrease levels of inflammatory factors. …"

Predicting the potential distribution of <i>Arisaema heterophyllum</i> in China under current and future climate change based on ArcGIS and MaxEnt model حسب Jing Xu (15337)

"…<p>Climate change significantly affects the distribution of medicinal plants, necessitating accurate models to predict future shifts in their habitats. …"

Table 1_Modulation of the gut-bone axis: Lacticaseibacillus paracasei LC86 improves bone health via anti-inflammatory metabolic pathways in zebrafish models of osteoporosis and car... حسب Yao Dong (3308124)

"…Gut microbiota analysis demonstrated an increase in beneficial bacteria and a decrease in pathogenic genera.…"

Table 1_Enhancement of oxaliplatin efficacy and amelioration of intestinal epithelial damage by Lactobacillus rhamnosus GG through modulation of gut microbiota.xlsx حسب Zijie Zhang (2543533)

"…</p>Results<p>The combined treatment of LGG and Oxp significantly reduced tumor weight and volume, and improved tumor-associated pathological changes compared to the model group. …"

OMT حسب Jingmin Ou (19669426)

"…<p dir="ltr">In this study, we performed a series of experiments to investigate the effects of oxymatrine (OMT) on hemangioma cells and its mechanisms. OMT was found to significantly increase the apoptosis rate of endothelial cells (ECs) treated with oxidised low-density lipoprotein (ox-LDL), as measured by caspase-3 activity assay and flow cytometry. qRT-PCR results showed that OMT treatment decreased the expression of miR-199a-5p in ECs.Transfection of miR-199a-5p mimics enhanced the apoptotic effect, whereas miR-199a-5p inhibitors attenuated apoptosis, suggesting that miR-199a-5p has a key regulatory role in EC apoptosis. …"

Data Sheet 1_A ROS-responsive, aptamer-targeted graphene oxide nanocomposite for site-specific glutathione release in cerebral ischemia-reperfusion injury.docx حسب Meiying Li (6051287)

"…In vitro, GO@GSH-FA significantly restored viability in oxygen-glucose-deprived SH-SY5Y cells (from 31% up to near control levels), reduced inflammatory cytokines, and lowered intracellular ROS. …"

DataSheet1_FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression.ZIP حسب Guoan Xiang (383282)

"…</p>Results<p>We found that when the expression of miR-223 increased, FOXO1 expression decreased and autophagy decreased; whereas, when FOXO1 expression was inhibited, autophagy decreased significantly in different cell models after LPS induction.…"