Table 1_Next-generation sequencing of mitochondrial DNA reveals pathogenic variants and protective haplogroup D4 in esophageal cancer.xlsx by Xiucheng Jiang (18849564)

“…Notably, mitochondrial haplogroup D4 was significantly associated with a decreased risk of developing EC. …”

Data Sheet 1_Multi-compartment immune cell profiling highlights the prognostic relevance of CD127+ CD8+ T cells for patients with high-grade serous ovarian cancer.docx by Rebecca Rothe (10292883)

“…In addition, immune cell subsets varied significantly in their differentiation and phenotypic marker expression. …”

Image 1_Metformin enhances alpelisib sensitivity in HER2+ breast cancer by suppressing cancer stemness and oncogenic signaling.tif by Yujie Shi (737203)

“…Combination treatment induced significant G0/G1 cell-cycle arrest, reduced ALDH1⁺ populations, and decreased tumorsphere formation. …”

Table 4_Apoptosis and autophagy promote Babesia microti infection in tick midguts: insights from transcriptomic and functional RNAi studies.xls by Songqin Chen (9625886)

“…Functional assays demonstrated that RNA interference (RNAi)-mediated knockdown of caspase-7, caspase-9, and ATG5 significantly reduced the burden of B. microti. Conversely, pharmacological induction of autophagy using rapamycin increased B. microti load, whereas inhibition with 3-methyladenine (3-MA) decreased B. microti load.…”

Image 2_Interleukin-26 expression in tuberculosis disease and its regulatory effect in macrophage polarization and intracellular elimination of Mycobacterium tuberculosis.jpeg by Kaisong Huang (5412626)

“…In this study, we observed significantly elevated IL-26 mRNA expression in peripheral blood mononuclear cells of active-TB patients compared to healthy individuals. …”

DataSheet2_Dysregulation of the 3β-hydroxysteroid dehydrogenase type 2 enzyme and steroid hormone biosynthesis in chronic kidney disease.xlsx by Yiyi Zuo (19945293)

“…</p>Results<p>Metabolic characteristics revealed significant shifts in CKD, with 61 metabolites increased and 65 metabolites decreased, highlighting the disruption in steroid hormone biosynthesis pathways influenced by HSD3B2. …”

Image 1_Application and validation of the machine learning-based multimodal radiomics model for preoperative prediction of lateral lymph node metastasis in papillary thyroid carcin... by Jia-Wei Feng (10754067)

“…Current diagnostic methods show significant limitations, with occult LLNM rates of 41.0%-51.7% requiring secondary surgeries. …”

Data Sheet 1_Visual attention during non-immersive virtual reality balance training in older adults with mild to moderate cognitive impairment: an eye-tracking study.pdf by Marcos Maldonado-Díaz (11221102)

“…Clinical tests revealed a slight increase, though results were not statistically significant in balance and walking speed (p = 0.063). …”

Table_4_Functional Characterization of Olfactory Proteins Involved in Chemoreception of Galeruca daurica.docx by Ling Li (38566)

“…The EAG response of G. daurica females to 2-hexenal was significantly decreased in dsRNA-OBP15-injected treatment compared to the control, and the dsRNA-CSP5-treated females significantly reduced EAG response to eight tested host volatiles (1,3-dithiane, 2-hexenal, methyl benzoate, dimethyl trisulfide, myrcene, hexanal, 1,3,5-cycloheptatriene, and p-xylene). …”

Table1_Hypoxia-induced PD-L1 expression and modulation of muscle stem cell allograft rejection.pdf by Jacob Raiten (20021262)

“…In vivo, these preconditioned MuSCs led to decreased infiltration of CD4⁺ and CD8⁺ T cells in implanted limb muscles of mouse models. …”

Video 2_Muscle-specific Bet1L knockdown induces neuromuscular denervation, motor neuron degeneration, and motor dysfunction in a rat model of familial ALS.mp4 by Adam Eckardt (20573576)

“…Bet1L knockdown decreased motor neuron size in the lumbar spinal cord, which innervated the siRNA-injected hindlimb. …”

Table 2_High intake of n-6 polyunsaturated fatty acid exacerbates non-alcoholic steatohepatitis by the involvement of multiple metabolic pathways.docx by Jian-Tong (21583487)

“…Correlational analysis revealed significant associations between these pathways and inflammatory/oxidative markers. …”

Image1_Causal association between matrix metalloproteinases and diabetic neuropathy: a two-sample Mendelian randomization study.tif by Chao Bai (4428472)

“…Objective<p>Diabetic neuropathy (DN), a common and debilitating complication of diabetes, significantly impairs the quality of life of affected individuals. …”

Table 1_Cholesterol metabolic reprogramming drives the onset of DLBCL and represents a promising therapeutic target.docx by Lili Zhou (265076)

“…</p>Results<p>We confirmed significant alterations in metabolic markers (such as TC and ApoA1) between the healthy control group and patients, which were significantly associated with patient prognosis and overall OS. …”

Data Sheet 6_Global, regional, and national burden of musculoskeletal disorders, 1990–2021: an analysis of the global burden of disease study 2021 and forecast to 2035.pdf by Meizhi Liu (21898892)

“…Frontier analysis revealed significant gaps between current burdens and achievable benchmarks, particularly in high-SDI regions, while some low-SDI regions demonstrated effective management despite limited resources. …”

Evaluating the effectiveness of safety countermeasures at highway–railway grade crossing based on a machine learning framework by Mohammadali Zayandehroodi (19746176)

“…Then, the DCLA method achieved 4 distinct clusters optimized by high similarity within each cluster and significant independence among clusters. The effectiveness of countermeasures was computed in terms of CMF and SE. …”

Table 4_Global, regional, and national burden of musculoskeletal disorders, 1990–2021: an analysis of the global burden of disease study 2021 and forecast to 2035.doc by Meizhi Liu (21898892)

“…Frontier analysis revealed significant gaps between current burdens and achievable benchmarks, particularly in high-SDI regions, while some low-SDI regions demonstrated effective management despite limited resources. …”

Soil plant available silicon from a bamboo forest on karst mountain in southwest China differs between wet and dry seasons by Bin Xu (10691)

“…The soil water-soluble Si and organic matter showed no significant difference between wet and dry seasons. …”

Data Sheet 1_Radiomics reveals the biological basis for non-small cell lung cancer prognostic stratification by reflecting tumor immune microenvironment heterogeneity.docx by Qing Huang (240196)

“…Immune microenvironment profiling showed significantly reduced immune scores and decreased proportions of naive B cells in high-risk patients, indicating impaired immune activity. …”

Analysis diagram of Ecological carrying system. by Hui Li (32376)

“…Our results indicate significant changes in land types within the TGRR from 1986 to 2020, with decreases in arable land, forest land, and grassland, while water bodies, building land, and unused land increased. …”