Data Sheet 1_An exploratory analysis of bezisterim treatment associated with decreased biological age acceleration, and improved clinical measure and biomarker changes in mild-to-m... by Christopher L. Reading (21236861)

“…</p>Methods<p>In a 7-month, randomized, double-blind, placebo-controlled trial (NCT04669028), we investigated the safety and activity of bezisterim, a first-in-class, oral, blood–brain barrier–permeable, anti-inflammatory agent on cognitive, molecular, biochemical, physiological, and biological aging parameters in a subset of 50 mild-to-moderate probable Alzheimer's disease participants. These participants had source-document-verified clinical measures and samples, and they completed the protocol. …”

Effects of GJE extract treatment decreased serum ALT and AST levels. by Natnicha Suttawong (22367172)

Summary of the expected results with corresponding hypotheses. by Marcel F. Hinss (14675457)

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The Ishihara test for colourblindness [41] encompasses stimuli that can determine the degree and type of colourblindness a person has. by Marcel F. Hinss (14675457)

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The demographics questionnaire includes questions about age, education, gender and employment. by Marcel F. Hinss (14675457)

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RTs (in ms, bars) and ACC (in%, line) across time points, with 95% confidence interval. by Marcel F. Hinss (14675457)

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RTs (in ms, bars) and ACC (in %, line) for the rebound effect, with 95% confidence interval. by Marcel F. Hinss (14675457)

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The Samn-Perelli Scale is a 7-point Likert scale used to assess fatigue [42, 45]. by Marcel F. Hinss (14675457)

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Examples of different stimuli for all subtasks of the task. by Marcel F. Hinss (14675457)

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The St Mary’s Hospital Sleep Questionnaire was used to estimate the sleep quality on the previous night. by Marcel F. Hinss (14675457)

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The Karolinska Sleepiness Scale (KSS) is a 9-point Likert scale, ranging from “extremely 1 = alert” to “9 = extremely sleepy–fighting sleep” [44]. by Marcel F. Hinss (14675457)

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RTs (in ms, bars) and ACC (in %, line) for each simplified task-rule congruency condition, with 95% confidence interval. by Marcel F. Hinss (14675457)

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Summary of demographics: Left: Distribution of age; Right: Distribution of handedness as assessed by the EDI [40]. by Marcel F. Hinss (14675457)

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Schema of the experimental procedure. by Marcel F. Hinss (14675457)

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Summary of effects of gender on RT (in ms, bars) and ACC (in %, line), with 95% confidence interval. by Marcel F. Hinss (14675457)

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RTs (in ms, bars) and ACC (in %, line) across different types of task-rule congruency, with 95% confidence interval. by Marcel F. Hinss (14675457)

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RTs (in ms, bars) and ACC (in %, line) across all tasks, with 95% confidence interval. by Marcel F. Hinss (14675457)

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Larger example of stimuli with cue relevant for Task 3. by Marcel F. Hinss (14675457)

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The shortened version of the Edinburgh Handedness Inventory encompasses 4 items (e.g. writing) scored on a 5-point scale ranging from:” Always right; usually right; both equally; u... by Marcel F. Hinss (14675457)

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Examples of the different task-rule congruency conditions. by Marcel F. Hinss (14675457)

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